Association between vitamin D level and bronchopulmonary dysplasia: A systematic review and meta-analysis.
Neonatal vitamin D deficiency is common and is associated with development of pulmonary disease in children and adults. While the role of vitamin D in normal lung development is well established, the association between vitamin D deficiency and bronchopulmonary dysplasia (BPD) remains unclear. The p...
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Public Library of Science (PLoS)
2020-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0235332&type=printable |
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| author | Hye Won Park Gina Lim Yong-Mean Park Misoo Chang Jae Sung Son Ran Lee |
| author_facet | Hye Won Park Gina Lim Yong-Mean Park Misoo Chang Jae Sung Son Ran Lee |
| author_sort | Hye Won Park |
| collection | DOAJ |
| description | Neonatal vitamin D deficiency is common and is associated with development of pulmonary disease in children and adults. While the role of vitamin D in normal lung development is well established, the association between vitamin D deficiency and bronchopulmonary dysplasia (BPD) remains unclear. The present meta-analysis was conducted to evaluate the relationship between vitamin D and BPD. We identified relevant studies (n = 8) using the PubMed, EMBASE, Cochrane Library, and KoreaMed databases and applied the Newcastle-Ottawa Scale to assess the methodological components of each study, and used I2 statistic to evaluate heterogeneity. Comprehensive Meta-Analysis software version 3.3 was used for the statistical analysis. A total of 909 infants were included, of whom 251 (27.6%) were diagnosed with BPD. We found that both vitamin D deficiency at birth (four studies; OR 2.405; 95% CI 1.269 to 4.560; p = 0.007) and low levels of vitamin D at birth (four studies; standardized mean difference -1.463; 95% CI -2.900 to -0.027; p = 0.046) were associated with BPD. The compiled data suggest that antenatal vitamin D deficiency and low vitamin D levels are associated with neonatal BPD. |
| format | Article |
| id | doaj-art-563628011d6b4491ad9ec9ec0fc9bd51 |
| institution | OA Journals |
| issn | 1932-6203 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-563628011d6b4491ad9ec9ec0fc9bd512025-08-20T02:00:46ZengPublic Library of Science (PLoS)PLoS ONE1932-62032020-01-01157e023533210.1371/journal.pone.0235332Association between vitamin D level and bronchopulmonary dysplasia: A systematic review and meta-analysis.Hye Won ParkGina LimYong-Mean ParkMisoo ChangJae Sung SonRan LeeNeonatal vitamin D deficiency is common and is associated with development of pulmonary disease in children and adults. While the role of vitamin D in normal lung development is well established, the association between vitamin D deficiency and bronchopulmonary dysplasia (BPD) remains unclear. The present meta-analysis was conducted to evaluate the relationship between vitamin D and BPD. We identified relevant studies (n = 8) using the PubMed, EMBASE, Cochrane Library, and KoreaMed databases and applied the Newcastle-Ottawa Scale to assess the methodological components of each study, and used I2 statistic to evaluate heterogeneity. Comprehensive Meta-Analysis software version 3.3 was used for the statistical analysis. A total of 909 infants were included, of whom 251 (27.6%) were diagnosed with BPD. We found that both vitamin D deficiency at birth (four studies; OR 2.405; 95% CI 1.269 to 4.560; p = 0.007) and low levels of vitamin D at birth (four studies; standardized mean difference -1.463; 95% CI -2.900 to -0.027; p = 0.046) were associated with BPD. The compiled data suggest that antenatal vitamin D deficiency and low vitamin D levels are associated with neonatal BPD.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0235332&type=printable |
| spellingShingle | Hye Won Park Gina Lim Yong-Mean Park Misoo Chang Jae Sung Son Ran Lee Association between vitamin D level and bronchopulmonary dysplasia: A systematic review and meta-analysis. PLoS ONE |
| title | Association between vitamin D level and bronchopulmonary dysplasia: A systematic review and meta-analysis. |
| title_full | Association between vitamin D level and bronchopulmonary dysplasia: A systematic review and meta-analysis. |
| title_fullStr | Association between vitamin D level and bronchopulmonary dysplasia: A systematic review and meta-analysis. |
| title_full_unstemmed | Association between vitamin D level and bronchopulmonary dysplasia: A systematic review and meta-analysis. |
| title_short | Association between vitamin D level and bronchopulmonary dysplasia: A systematic review and meta-analysis. |
| title_sort | association between vitamin d level and bronchopulmonary dysplasia a systematic review and meta analysis |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0235332&type=printable |
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