Neuroprotective effects of astaxanthin in a scopolamine-induced rat model of Alzheimer’s disease through antioxidant/anti-inflammatory pathways and opioid/benzodiazepine receptors: attenuation of Nrf2, NF-κB, and interconnected pathways

Neuroprotective effects of astaxanthin in a scopolamine-induced rat model of Alzheimer’s disease through antioxidant/anti-inflammatory pathways and opioid/benzodiazepine receptors: attenuation of Nrf2, NF-κB, and interconnected pathways

BackgroundGiven the complexity of pathological mechanisms behind Alzheimer’s disease (AD), there is a pressing need for novel multi-targeting therapeutic agents. Astaxanthin, a natural compound with diverse biological effects, has emerged as a potential candidate in neuronal diseases.PurposeThis stu...

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Bibliographic Details
Main Authors: Zeinab Rastinpour, Sajad Fakhri, Fatemeh Abbaszadeh, Mohammad Ranjbari, Amir Kiani, Mohammed Namiq Amin, Javier Echeverría
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Pharmacology
Subjects:
astaxanthin
Alzheimer’s disease
neuroinflammation
NF-κB
matrix metalloproteinase
oxidative stress
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1589751/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1589751/full

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