Sustained release biodegradable solid lipid microparticles: Formulation, evaluation and statistical optimization by response surface methodology

Sustained release biodegradable solid lipid microparticles: Formulation, evaluation and statistical optimization by response surface methodology

For preparing nebivolol loaded solid lipid microparticles (SLMs) by the solvent evaporation microencapsulation process from carnauba wax and glyceryl monostearate, central composite design was used to study the impact of independent variables on yield (Y1), entrapment efficiency (Y2) and drug releas...

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Bibliographic Details
Main Authors: Hanif Muhammad, Khan Hafeez Ullah, Afzal Samina, Mahmood Asif, Maheen Safirah, Afzal Khurram, Iqbal Nabila, Andleeb Mehwish, Abbas Nazar
Format: Article
Language:English
Published: Sciendo 2017-12-01
Series:Acta Pharmaceutica
Subjects:
central composite design
differential scanning calorimetry
solid lipid microparticles
microencapsulation
nebivolol
carnauba wax
Online Access:https://doi.org/10.1515/acph-2017-0034
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