Covalent Organic Frameworks for Immunoassays: A Review
Immunoassays relying on highly specific antigen–antibody recognition are important tools for effectively measuring the levels of various targets. Efforts have been made in the development of various methods to improve the detection sensitivity and stability of immunoassays. Covalent organic framewor...
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| Format: | Article |
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MDPI AG
2025-07-01
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| Series: | Biosensors |
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| Online Access: | https://www.mdpi.com/2079-6374/15/7/469 |
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| author | Suling Yang Hongmin Liu |
| author_facet | Suling Yang Hongmin Liu |
| author_sort | Suling Yang |
| collection | DOAJ |
| description | Immunoassays relying on highly specific antigen–antibody recognition are important tools for effectively measuring the levels of various targets. Efforts have been made in the development of various methods to improve the detection sensitivity and stability of immunoassays. Covalent organic frameworks (COFs), as an emerging class of novel crystalline porous materials, have unique advantages such as flexible designability, high surface area, excellent stability, tunable pore sizes, and multiple functionalities. They have great potential as novel sensory materials. Herein, we summarize the advances of COFs in electrochemical and optical immunoassays serving as electrode modifiers, signal indicators, enzyme or probe carriers, etc. Meanwhile, the design and application of typical COFs-based immunoassays in the determination of different targets are discussed in detail. Finally, challenges and future perspectives are presented. |
| format | Article |
| id | doaj-art-562bf60f34ac4072930a769e2d577bad |
| institution | Kabale University |
| issn | 2079-6374 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biosensors |
| spelling | doaj-art-562bf60f34ac4072930a769e2d577bad2025-08-20T03:58:30ZengMDPI AGBiosensors2079-63742025-07-0115746910.3390/bios15070469Covalent Organic Frameworks for Immunoassays: A ReviewSuling Yang0Hongmin Liu1Henan Province Key Laboratory of New Opto-Electronic Functional Materials, College of Chemistry and Chemical Engineering, Anyang Normal University, Anyang 455000, ChinaHenan Province Key Laboratory of New Opto-Electronic Functional Materials, College of Chemistry and Chemical Engineering, Anyang Normal University, Anyang 455000, ChinaImmunoassays relying on highly specific antigen–antibody recognition are important tools for effectively measuring the levels of various targets. Efforts have been made in the development of various methods to improve the detection sensitivity and stability of immunoassays. Covalent organic frameworks (COFs), as an emerging class of novel crystalline porous materials, have unique advantages such as flexible designability, high surface area, excellent stability, tunable pore sizes, and multiple functionalities. They have great potential as novel sensory materials. Herein, we summarize the advances of COFs in electrochemical and optical immunoassays serving as electrode modifiers, signal indicators, enzyme or probe carriers, etc. Meanwhile, the design and application of typical COFs-based immunoassays in the determination of different targets are discussed in detail. Finally, challenges and future perspectives are presented.https://www.mdpi.com/2079-6374/15/7/469electrochemical immunoassaysoptical immunoassayscovalent organic frameworkselectrode materialssignal labels |
| spellingShingle | Suling Yang Hongmin Liu Covalent Organic Frameworks for Immunoassays: A Review Biosensors electrochemical immunoassays optical immunoassays covalent organic frameworks electrode materials signal labels |
| title | Covalent Organic Frameworks for Immunoassays: A Review |
| title_full | Covalent Organic Frameworks for Immunoassays: A Review |
| title_fullStr | Covalent Organic Frameworks for Immunoassays: A Review |
| title_full_unstemmed | Covalent Organic Frameworks for Immunoassays: A Review |
| title_short | Covalent Organic Frameworks for Immunoassays: A Review |
| title_sort | covalent organic frameworks for immunoassays a review |
| topic | electrochemical immunoassays optical immunoassays covalent organic frameworks electrode materials signal labels |
| url | https://www.mdpi.com/2079-6374/15/7/469 |
| work_keys_str_mv | AT sulingyang covalentorganicframeworksforimmunoassaysareview AT hongminliu covalentorganicframeworksforimmunoassaysareview |