Effects of POPs-induced SIRT6 alteration on intestinal mucosal barrier function: A comprehensive review
Persistent organic pollutants (POPs) are pervasive organic chemicals with significant environmental and ecological ramifications, extending to adverse human health effects due to their toxicity and persistence. The intestinal mucosal barrier, a sophisticated defense mechanism comprising the epitheli...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-01-01
|
| Series: | Ecotoxicology and Environmental Safety |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651325000417 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832590953965158400 |
|---|---|
| author | Guangcan Chen Tengyang Huang Yifeng Dai Xia Huo Xijin Xu |
| author_facet | Guangcan Chen Tengyang Huang Yifeng Dai Xia Huo Xijin Xu |
| author_sort | Guangcan Chen |
| collection | DOAJ |
| description | Persistent organic pollutants (POPs) are pervasive organic chemicals with significant environmental and ecological ramifications, extending to adverse human health effects due to their toxicity and persistence. The intestinal mucosal barrier, a sophisticated defense mechanism comprising the epithelial layer, mucosal chemistry, and cellular immunity, shields the host from external threats and fosters a symbiotic relationship with intestinal bacteria. Sirtuin 6 (SIRT6), a sirtuin family member, is pivotal in genome and telomere stability, inflammation regulation, and metabolic processes. Result shows POPs have been implicated in the intestinal diseases, particularly in intestinal barrier dysfunction, through mechanisms such as cellular damage, epigenetic alterations, inflammation, microbiota changes, and metabolic disruptions. While the impact of SIRT6 expression changes on intestinal barrier functions has been reviewed, the mechanisms linking POPs to SIRT6 remain elusive. This review summarized the latest research results on the effects of POPs on intestinal barrier, discussed the role of SIRT6 from multiple mechanism perspectives, proposed new research directions on POPs, SIRT6 and intestinal health, and explored the therapeutic potential of SIRT6. |
| format | Article |
| id | doaj-art-562bf1ca20fd4372a963e00fced5aea0 |
| institution | Kabale University |
| issn | 0147-6513 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj-art-562bf1ca20fd4372a963e00fced5aea02025-01-23T05:26:10ZengElsevierEcotoxicology and Environmental Safety0147-65132025-01-01289117705Effects of POPs-induced SIRT6 alteration on intestinal mucosal barrier function: A comprehensive reviewGuangcan Chen0Tengyang Huang1Yifeng Dai2Xia Huo3Xijin Xu4Laboratory of Environmental Medicine and Developmental Toxicology, Shantou University Medical College, Shantou, Guangdong 515041, China; Department of Digestive Surgery, the First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong 515000, ChinaLaboratory of Environmental Medicine and Developmental Toxicology, Shantou University Medical College, Shantou, Guangdong 515041, China; Department of Digestive Surgery, the First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong 515000, ChinaLaboratory of Environmental Medicine and Developmental Toxicology, Shantou University Medical College, Shantou, Guangdong 515041, China; Department of Global Public Health and Bioethics, Julius Center for Health Sciences and Primary Care, University Medical Centre Utrecht, the NetherlandsLaboratory of Environmental Medicine and Developmental Toxicology, Guangdong Key Laboratory of Environmental Pollution and Health, School of Environment, Jinan University, Guangdong, Guangzhou 511443, ChinaLaboratory of Environmental Medicine and Developmental Toxicology, Shantou University Medical College, Shantou, Guangdong 515041, China; Department of Cell Biology and Genetics, Shantou University Medical College, Shantou, Guangdong 515041, China; Corresponding author at: Laboratory of Environmental Medicine and Developmental Toxicology, Shantou University Medical College, Shantou, Guangdong 515041, China.Persistent organic pollutants (POPs) are pervasive organic chemicals with significant environmental and ecological ramifications, extending to adverse human health effects due to their toxicity and persistence. The intestinal mucosal barrier, a sophisticated defense mechanism comprising the epithelial layer, mucosal chemistry, and cellular immunity, shields the host from external threats and fosters a symbiotic relationship with intestinal bacteria. Sirtuin 6 (SIRT6), a sirtuin family member, is pivotal in genome and telomere stability, inflammation regulation, and metabolic processes. Result shows POPs have been implicated in the intestinal diseases, particularly in intestinal barrier dysfunction, through mechanisms such as cellular damage, epigenetic alterations, inflammation, microbiota changes, and metabolic disruptions. While the impact of SIRT6 expression changes on intestinal barrier functions has been reviewed, the mechanisms linking POPs to SIRT6 remain elusive. This review summarized the latest research results on the effects of POPs on intestinal barrier, discussed the role of SIRT6 from multiple mechanism perspectives, proposed new research directions on POPs, SIRT6 and intestinal health, and explored the therapeutic potential of SIRT6.http://www.sciencedirect.com/science/article/pii/S0147651325000417Pollutant exposureNAD+-dependent deacetylaseInflammatory responsesEpigenetic modificationIntestinal microbiome |
| spellingShingle | Guangcan Chen Tengyang Huang Yifeng Dai Xia Huo Xijin Xu Effects of POPs-induced SIRT6 alteration on intestinal mucosal barrier function: A comprehensive review Ecotoxicology and Environmental Safety Pollutant exposure NAD+-dependent deacetylase Inflammatory responses Epigenetic modification Intestinal microbiome |
| title | Effects of POPs-induced SIRT6 alteration on intestinal mucosal barrier function: A comprehensive review |
| title_full | Effects of POPs-induced SIRT6 alteration on intestinal mucosal barrier function: A comprehensive review |
| title_fullStr | Effects of POPs-induced SIRT6 alteration on intestinal mucosal barrier function: A comprehensive review |
| title_full_unstemmed | Effects of POPs-induced SIRT6 alteration on intestinal mucosal barrier function: A comprehensive review |
| title_short | Effects of POPs-induced SIRT6 alteration on intestinal mucosal barrier function: A comprehensive review |
| title_sort | effects of pops induced sirt6 alteration on intestinal mucosal barrier function a comprehensive review |
| topic | Pollutant exposure NAD+-dependent deacetylase Inflammatory responses Epigenetic modification Intestinal microbiome |
| url | http://www.sciencedirect.com/science/article/pii/S0147651325000417 |
| work_keys_str_mv | AT guangcanchen effectsofpopsinducedsirt6alterationonintestinalmucosalbarrierfunctionacomprehensivereview AT tengyanghuang effectsofpopsinducedsirt6alterationonintestinalmucosalbarrierfunctionacomprehensivereview AT yifengdai effectsofpopsinducedsirt6alterationonintestinalmucosalbarrierfunctionacomprehensivereview AT xiahuo effectsofpopsinducedsirt6alterationonintestinalmucosalbarrierfunctionacomprehensivereview AT xijinxu effectsofpopsinducedsirt6alterationonintestinalmucosalbarrierfunctionacomprehensivereview |