Optimization Studies on the Extraction of Flavone Di-C-glycosides from Premna fulva Craib by Deep Eutectic Solvents
Deep eutectic solvents (DESs) are emerging as new extraction solvents for the extraction of bioactive compounds from natural plants. In this work, a total of thirteen choline chloride-based DESs were synthesized and evaluated for the simultaneous extraction of five bioactive flavone di-C-glycosides...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2020-01-01
|
| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2020/7240535 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832550415616442368 |
|---|---|
| author | Yueyuan Chen Jiaoyang Dang Xiaojie Yan Fenglai Lu Dianpeng Li |
| author_facet | Yueyuan Chen Jiaoyang Dang Xiaojie Yan Fenglai Lu Dianpeng Li |
| author_sort | Yueyuan Chen |
| collection | DOAJ |
| description | Deep eutectic solvents (DESs) are emerging as new extraction solvents for the extraction of bioactive compounds from natural plants. In this work, a total of thirteen choline chloride-based DESs were synthesized and evaluated for the simultaneous extraction of five bioactive flavone di-C-glycosides from Premna fulva Craib. DES-F, which was composed of choline chloride and 1,3-propanediol, showed the best extraction efficiency for the flavone di-C-glycosides, exceeding that of the conventional industrial solvent (40% ethanol). Subsequently, the extraction parameters for ultrasonic-assisted extraction (liquid-solid ratio, water content (%) in the selected DES, and extraction time) were optimized using response surface methodology. Furthermore, the microstructural alterations in the samples after extraction were evaluated using scanning electron microscopy. In addition, we further verified the recovery of flavone di-C-glycosides from the DESs using macroporous resins and evaluated the reusability of the DESs as solvents. The results indicated that DES-F was an efficient and sustainable solvent for the extraction of bioactive flavone di-C-glycosides from Premna fulva Craib. Therefore, this novel strategy may represent a sustainable approach for the extraction of bioactive products and could make phytochemistry more attractive and environmentally friendly. |
| format | Article |
| id | doaj-art-5621eb0067ad4df3a1063860f789a38c |
| institution | Kabale University |
| issn | 2090-9063 2090-9071 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Chemistry |
| spelling | doaj-art-5621eb0067ad4df3a1063860f789a38c2025-02-03T06:06:44ZengWileyJournal of Chemistry2090-90632090-90712020-01-01202010.1155/2020/72405357240535Optimization Studies on the Extraction of Flavone Di-C-glycosides from Premna fulva Craib by Deep Eutectic SolventsYueyuan Chen0Jiaoyang Dang1Xiaojie Yan2Fenglai Lu3Dianpeng Li4Guangxi Key Laboratory of Functional Phytochemicals Research and Utilization, Institute of Botany, Guangxi Zhuang Autonomous Region and Chinese Academy of Sciences, Guilin 541006, ChinaGuangxi Key Laboratory of Functional Phytochemicals Research and Utilization, Institute of Botany, Guangxi Zhuang Autonomous Region and Chinese Academy of Sciences, Guilin 541006, ChinaGuangxi Key Laboratory of Functional Phytochemicals Research and Utilization, Institute of Botany, Guangxi Zhuang Autonomous Region and Chinese Academy of Sciences, Guilin 541006, ChinaGuangxi Key Laboratory of Functional Phytochemicals Research and Utilization, Institute of Botany, Guangxi Zhuang Autonomous Region and Chinese Academy of Sciences, Guilin 541006, ChinaGuangxi Key Laboratory of Functional Phytochemicals Research and Utilization, Institute of Botany, Guangxi Zhuang Autonomous Region and Chinese Academy of Sciences, Guilin 541006, ChinaDeep eutectic solvents (DESs) are emerging as new extraction solvents for the extraction of bioactive compounds from natural plants. In this work, a total of thirteen choline chloride-based DESs were synthesized and evaluated for the simultaneous extraction of five bioactive flavone di-C-glycosides from Premna fulva Craib. DES-F, which was composed of choline chloride and 1,3-propanediol, showed the best extraction efficiency for the flavone di-C-glycosides, exceeding that of the conventional industrial solvent (40% ethanol). Subsequently, the extraction parameters for ultrasonic-assisted extraction (liquid-solid ratio, water content (%) in the selected DES, and extraction time) were optimized using response surface methodology. Furthermore, the microstructural alterations in the samples after extraction were evaluated using scanning electron microscopy. In addition, we further verified the recovery of flavone di-C-glycosides from the DESs using macroporous resins and evaluated the reusability of the DESs as solvents. The results indicated that DES-F was an efficient and sustainable solvent for the extraction of bioactive flavone di-C-glycosides from Premna fulva Craib. Therefore, this novel strategy may represent a sustainable approach for the extraction of bioactive products and could make phytochemistry more attractive and environmentally friendly.http://dx.doi.org/10.1155/2020/7240535 |
| spellingShingle | Yueyuan Chen Jiaoyang Dang Xiaojie Yan Fenglai Lu Dianpeng Li Optimization Studies on the Extraction of Flavone Di-C-glycosides from Premna fulva Craib by Deep Eutectic Solvents Journal of Chemistry |
| title | Optimization Studies on the Extraction of Flavone Di-C-glycosides from Premna fulva Craib by Deep Eutectic Solvents |
| title_full | Optimization Studies on the Extraction of Flavone Di-C-glycosides from Premna fulva Craib by Deep Eutectic Solvents |
| title_fullStr | Optimization Studies on the Extraction of Flavone Di-C-glycosides from Premna fulva Craib by Deep Eutectic Solvents |
| title_full_unstemmed | Optimization Studies on the Extraction of Flavone Di-C-glycosides from Premna fulva Craib by Deep Eutectic Solvents |
| title_short | Optimization Studies on the Extraction of Flavone Di-C-glycosides from Premna fulva Craib by Deep Eutectic Solvents |
| title_sort | optimization studies on the extraction of flavone di c glycosides from premna fulva craib by deep eutectic solvents |
| url | http://dx.doi.org/10.1155/2020/7240535 |
| work_keys_str_mv | AT yueyuanchen optimizationstudiesontheextractionofflavonedicglycosidesfrompremnafulvacraibbydeepeutecticsolvents AT jiaoyangdang optimizationstudiesontheextractionofflavonedicglycosidesfrompremnafulvacraibbydeepeutecticsolvents AT xiaojieyan optimizationstudiesontheextractionofflavonedicglycosidesfrompremnafulvacraibbydeepeutecticsolvents AT fenglailu optimizationstudiesontheextractionofflavonedicglycosidesfrompremnafulvacraibbydeepeutecticsolvents AT dianpengli optimizationstudiesontheextractionofflavonedicglycosidesfrompremnafulvacraibbydeepeutecticsolvents |