Thyrotropin exacerbates insulin resistance by triggering macrophage inflammation in subclinical hypothyroidism

Abstract In subclinical hypothyroidism, the levels of serum thyroid-stimulating hormone (TSH) are positively correlated with insulin resistance; however, the precise mechanism is unclear. Except for thyroid follicular epithelial cells, macrophages express the highest levels of TSHR. Thus, we specula...

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Bibliographic Details
Main Authors: Haihong Zhang, Zekun Zeng, Yan Liu, Wenfang Zheng, Jianling Wang, Yao Yao, Yanan Wang, Meiju Ji, Peng Hou
Format: Article
Language:English
Published: Nature Publishing Group 2025-06-01
Series:Experimental and Molecular Medicine
Online Access:https://doi.org/10.1038/s12276-025-01478-1
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