Role of FNA and Core Biopsy of Primary and Metastatic Liver Disease
Objective. To examine our experience with cytology and histology biopsy of the liver and to define methods for improvement of diagnosis of primary liver tumors. Methods. This include retrospective study of 189 biopsies of 185 liver masses for cytological or histological analysis. Patients were subdi...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | International Journal of Hepatology |
| Online Access: | http://dx.doi.org/10.1155/2013/174103 |
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| author | John P. McGahan John Bishop John Webb Lydia Howell Natalie Torok Ramit Lamba Michael T. Corwin |
| author_facet | John P. McGahan John Bishop John Webb Lydia Howell Natalie Torok Ramit Lamba Michael T. Corwin |
| author_sort | John P. McGahan |
| collection | DOAJ |
| description | Objective. To examine our experience with cytology and histology biopsy of the
liver and to define methods for improvement of diagnosis of primary liver tumors. Methods. This include retrospective study of 189 biopsies of 185 liver masses for cytological or histological analysis. Patients were subdivided into two groups. Group 1 consisted of 124 suspected metastasis. Group 2 consisted of 61 suspected primary neoplasms. Biopsies were considered positive or equivocal. In equivocal cases, special stains were performed. In Group 2, cases were classified by contrast CT or MRI as to (I) classic HCC, (II) infiltrated HCC, or (Ill) equivocal. Results. Definitive diagnosis was obtained in 117/124 masses (94%) in Group 1, 48/61 masses (79%) in Group 2, and (Ill) equivocal 13 cases in Group II. In two equivocal cases in which special stains were performed, they were reclassified as HCC. In 8/13 cases, CT findings were consistent with HCC. Conclusion. Liver biopsies are useful in obtaining a definitive diagnosis of suspected metastatic liver disease. Biopsy results are less reliable in patients with suspected primary liver tumors. In these situations, strategies can include basing treatment on imaging criteria or use of newer special pathological stains. Advances in Knowledge. Use of newer special immunological stains improves accuracy in definitive diagnosis of primary liver tumors. |
| format | Article |
| id | doaj-art-56205ea9bddb4a689fd6144d19a538ec |
| institution | OA Journals |
| issn | 2090-3448 2090-3456 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Hepatology |
| spelling | doaj-art-56205ea9bddb4a689fd6144d19a538ec2025-08-20T02:04:58ZengWileyInternational Journal of Hepatology2090-34482090-34562013-01-01201310.1155/2013/174103174103Role of FNA and Core Biopsy of Primary and Metastatic Liver DiseaseJohn P. McGahan0John Bishop1John Webb2Lydia Howell3Natalie Torok4Ramit Lamba5Michael T. Corwin6Davis Medical Center, Department of Radiology, University of California, 4860 Y Street, Suite 3100, Sacramento, CA 95817, USADavis Medical Center, Department of Pathology, University of California, 4400 V Street, Path Building, Sacramento, CA 95817, USADavis Medical Center, Department of Radiology, University of California, 4860 Y Street, Suite 3100, Sacramento, CA 95817, USADavis Medical Center, Department of Pathology, University of California, 4400 V Street, Path Building, Sacramento, CA 95817, USADavis Medical Center, Department of Internal Medicine, University of California, 4150 V Street, Suite 3500, Sacramento, CA 95817, USADavis Medical Center, Department of Radiology, University of California, 4860 Y Street, Suite 3100, Sacramento, CA 95817, USADavis Medical Center, Department of Radiology, University of California, 4860 Y Street, Suite 3100, Sacramento, CA 95817, USAObjective. To examine our experience with cytology and histology biopsy of the liver and to define methods for improvement of diagnosis of primary liver tumors. Methods. This include retrospective study of 189 biopsies of 185 liver masses for cytological or histological analysis. Patients were subdivided into two groups. Group 1 consisted of 124 suspected metastasis. Group 2 consisted of 61 suspected primary neoplasms. Biopsies were considered positive or equivocal. In equivocal cases, special stains were performed. In Group 2, cases were classified by contrast CT or MRI as to (I) classic HCC, (II) infiltrated HCC, or (Ill) equivocal. Results. Definitive diagnosis was obtained in 117/124 masses (94%) in Group 1, 48/61 masses (79%) in Group 2, and (Ill) equivocal 13 cases in Group II. In two equivocal cases in which special stains were performed, they were reclassified as HCC. In 8/13 cases, CT findings were consistent with HCC. Conclusion. Liver biopsies are useful in obtaining a definitive diagnosis of suspected metastatic liver disease. Biopsy results are less reliable in patients with suspected primary liver tumors. In these situations, strategies can include basing treatment on imaging criteria or use of newer special pathological stains. Advances in Knowledge. Use of newer special immunological stains improves accuracy in definitive diagnosis of primary liver tumors.http://dx.doi.org/10.1155/2013/174103 |
| spellingShingle | John P. McGahan John Bishop John Webb Lydia Howell Natalie Torok Ramit Lamba Michael T. Corwin Role of FNA and Core Biopsy of Primary and Metastatic Liver Disease International Journal of Hepatology |
| title | Role of FNA and Core Biopsy of Primary and Metastatic Liver Disease |
| title_full | Role of FNA and Core Biopsy of Primary and Metastatic Liver Disease |
| title_fullStr | Role of FNA and Core Biopsy of Primary and Metastatic Liver Disease |
| title_full_unstemmed | Role of FNA and Core Biopsy of Primary and Metastatic Liver Disease |
| title_short | Role of FNA and Core Biopsy of Primary and Metastatic Liver Disease |
| title_sort | role of fna and core biopsy of primary and metastatic liver disease |
| url | http://dx.doi.org/10.1155/2013/174103 |
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