Integrative genomic and single-cell framework identifies druggable targets for colorectal cancer precision therapy

Integrative genomic and single-cell framework identifies druggable targets for colorectal cancer precision therapy

BackgroundColorectal cancer (CRC) remains a leading cause of cancer-related mortality worldwide. Despite therapeutic advances, there is a critical need to identify novel, effective, and safe drug targets to improve precision treatment strategies.MethodsWe developed a multi-layered framework integrat...

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Bibliographic Details
Main Authors: Yanggang Hong, Jiajun Li, Nuo Xu, Wanyi Shu, Feng Chen, Yuze Mi, Haigang Geng, Qian Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Immunology
Subjects:
colorectal cancer
genetics
druggable targets
single-cell transcriptomics
precision oncology
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1604154/full
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