Camrelizumab-induced immune-related toxic epidermal necrolysis in lung adenocarcinoma: a case report and literature review
Toxic epidermal necrolysis (TEN) is a rare and serious skin reaction. This study reports a case of a patient with lung adenocarcinoma (LUAD) who developed severe TEN after 8 days of treatment with Camrelizumab monotherapy. The patient’s condition was effectively relieved with high-dose corticosteroi...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-01-01
|
| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2024.1417936/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841543832198447104 |
|---|---|
| author | Man Sun Huan Zhou Dan Zang Chen-Guang Liu Jun Chen |
| author_facet | Man Sun Huan Zhou Dan Zang Chen-Guang Liu Jun Chen |
| author_sort | Man Sun |
| collection | DOAJ |
| description | Toxic epidermal necrolysis (TEN) is a rare and serious skin reaction. This study reports a case of a patient with lung adenocarcinoma (LUAD) who developed severe TEN after 8 days of treatment with Camrelizumab monotherapy. The patient’s condition was effectively relieved with high-dose corticosteroids and intravenous immunoglobulin therapy. The diagnosis and treatment of immune-related TEN are challenging. This is a rare and severe case of TEN associated with the use of Camrelizumab. Additionally, we provide an in-depth understanding of immune-related TEN, summarizing its characteristics and treatment progress through a literature review, aiming to provide reference for the clinical safe application of immune checkpoint inhibitors (ICIs). |
| format | Article |
| id | doaj-art-561daa27dbad47fba1d2c419f9ec7628 |
| institution | Kabale University |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-561daa27dbad47fba1d2c419f9ec76282025-01-13T05:10:18ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-01-011410.3389/fonc.2024.14179361417936Camrelizumab-induced immune-related toxic epidermal necrolysis in lung adenocarcinoma: a case report and literature reviewMan SunHuan ZhouDan ZangChen-Guang LiuJun ChenToxic epidermal necrolysis (TEN) is a rare and serious skin reaction. This study reports a case of a patient with lung adenocarcinoma (LUAD) who developed severe TEN after 8 days of treatment with Camrelizumab monotherapy. The patient’s condition was effectively relieved with high-dose corticosteroids and intravenous immunoglobulin therapy. The diagnosis and treatment of immune-related TEN are challenging. This is a rare and severe case of TEN associated with the use of Camrelizumab. Additionally, we provide an in-depth understanding of immune-related TEN, summarizing its characteristics and treatment progress through a literature review, aiming to provide reference for the clinical safe application of immune checkpoint inhibitors (ICIs).https://www.frontiersin.org/articles/10.3389/fonc.2024.1417936/fulllung adenocarcinomacamrelizumabimmune-related adverse eventstoxic epidermal necrolysisdrug adverse reactions |
| spellingShingle | Man Sun Huan Zhou Dan Zang Chen-Guang Liu Jun Chen Camrelizumab-induced immune-related toxic epidermal necrolysis in lung adenocarcinoma: a case report and literature review Frontiers in Oncology lung adenocarcinoma camrelizumab immune-related adverse events toxic epidermal necrolysis drug adverse reactions |
| title | Camrelizumab-induced immune-related toxic epidermal necrolysis in lung adenocarcinoma: a case report and literature review |
| title_full | Camrelizumab-induced immune-related toxic epidermal necrolysis in lung adenocarcinoma: a case report and literature review |
| title_fullStr | Camrelizumab-induced immune-related toxic epidermal necrolysis in lung adenocarcinoma: a case report and literature review |
| title_full_unstemmed | Camrelizumab-induced immune-related toxic epidermal necrolysis in lung adenocarcinoma: a case report and literature review |
| title_short | Camrelizumab-induced immune-related toxic epidermal necrolysis in lung adenocarcinoma: a case report and literature review |
| title_sort | camrelizumab induced immune related toxic epidermal necrolysis in lung adenocarcinoma a case report and literature review |
| topic | lung adenocarcinoma camrelizumab immune-related adverse events toxic epidermal necrolysis drug adverse reactions |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2024.1417936/full |
| work_keys_str_mv | AT mansun camrelizumabinducedimmunerelatedtoxicepidermalnecrolysisinlungadenocarcinomaacasereportandliteraturereview AT huanzhou camrelizumabinducedimmunerelatedtoxicepidermalnecrolysisinlungadenocarcinomaacasereportandliteraturereview AT danzang camrelizumabinducedimmunerelatedtoxicepidermalnecrolysisinlungadenocarcinomaacasereportandliteraturereview AT chenguangliu camrelizumabinducedimmunerelatedtoxicepidermalnecrolysisinlungadenocarcinomaacasereportandliteraturereview AT junchen camrelizumabinducedimmunerelatedtoxicepidermalnecrolysisinlungadenocarcinomaacasereportandliteraturereview |