Adipose-derived exosomes ameliorate skeletal muscle atrophy via miR-146a-5p/IGF-1R signaling

Adipose-derived exosomes ameliorate skeletal muscle atrophy via miR-146a-5p/IGF-1R signaling

Abstract The study of muscle disorders has gained popularity, with a particular emphasis on the relationship between adipose tissue and skeletal muscle. In our investigation, we discovered that the deletion of miR-146a-5p specifically in adipose tissue (aKO) led to a notable rise in mice’s mass and...

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Bibliographic Details
Main Authors: Mengran Qin, Jiahao Zhu, Lipeng Xing, Yaotian Fan, Junyi Luo, Jiajie Sun, Ting Chen, Yongliang Zhang, Qianyun Xi
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Journal of Nanobiotechnology
Subjects:
Muscle atrophy
IGF-1R
Exosomes
miR-146a-5p
Skeletal muscle
Adipose
Online Access:https://doi.org/10.1186/s12951-024-02983-7
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