Impact of the Human Microbiome on Nephrolithiasis
Nephrolithiasis has many causes, and its prevalence is increasing worldwide. The interest in the human microbiome is growing because of the advance of new diagnostic techniques, and recent studies have suggested a link between the microbiome and nephrolithiasis. This paper reviewed the role of the m...
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| Format: | Article |
| Language: | English |
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Korean Association of Urogenital Tract Infection and Inflammation
2021-08-01
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| Series: | Urogenital Tract Infection |
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| Online Access: | http://euti.org/upload/pdf/UTI016-02-25.pdf |
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| _version_ | 1849247445200928768 |
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| author | Hae Do Jung Joo Yong Lee |
| author_facet | Hae Do Jung Joo Yong Lee |
| author_sort | Hae Do Jung |
| collection | DOAJ |
| description | Nephrolithiasis has many causes, and its prevalence is increasing worldwide. The interest in the human microbiome is growing because of the advance of new diagnostic techniques, and recent studies have suggested a link between the microbiome and nephrolithiasis. This paper reviewed the role of the microbiome in nephrolithiasis. The absence of Oxalobacter formigenes induces hyperoxaluria, which promotes calcium oxalate stone (CaOx) formation. Escherichia coli promote CaOx supersaturation through hypocitraturia caused by the bacterial production of citrate lyase. Infection stones are associated with urea-splitting organisms, particularly Proteus mirabilis, and the stones themselves contain many species of bacteria. |
| format | Article |
| id | doaj-art-5616ef83bf8f41daad13b8ffae8891c8 |
| institution | Kabale University |
| issn | 2465-8243 2465-8510 |
| language | English |
| publishDate | 2021-08-01 |
| publisher | Korean Association of Urogenital Tract Infection and Inflammation |
| record_format | Article |
| series | Urogenital Tract Infection |
| spelling | doaj-art-5616ef83bf8f41daad13b8ffae8891c82025-08-20T03:58:14ZengKorean Association of Urogenital Tract Infection and InflammationUrogenital Tract Infection2465-82432465-85102021-08-01162253110.14777/uti.2021.16.2.25370Impact of the Human Microbiome on NephrolithiasisHae Do Jung0Joo Yong Lee1Department of Urology, Wonkwang University Sanbon Hospital, Wonkwang University School of Medicine, Gunpo, KoreaDepartment of Urology, Severance Hospital, Urological Science Institute, Yonsei University College of Medicine, Seoul, KoreaNephrolithiasis has many causes, and its prevalence is increasing worldwide. The interest in the human microbiome is growing because of the advance of new diagnostic techniques, and recent studies have suggested a link between the microbiome and nephrolithiasis. This paper reviewed the role of the microbiome in nephrolithiasis. The absence of Oxalobacter formigenes induces hyperoxaluria, which promotes calcium oxalate stone (CaOx) formation. Escherichia coli promote CaOx supersaturation through hypocitraturia caused by the bacterial production of citrate lyase. Infection stones are associated with urea-splitting organisms, particularly Proteus mirabilis, and the stones themselves contain many species of bacteria.http://euti.org/upload/pdf/UTI016-02-25.pdfmicrobiotanephrolithiasisgastrointestinal microbiome |
| spellingShingle | Hae Do Jung Joo Yong Lee Impact of the Human Microbiome on Nephrolithiasis Urogenital Tract Infection microbiota nephrolithiasis gastrointestinal microbiome |
| title | Impact of the Human Microbiome on Nephrolithiasis |
| title_full | Impact of the Human Microbiome on Nephrolithiasis |
| title_fullStr | Impact of the Human Microbiome on Nephrolithiasis |
| title_full_unstemmed | Impact of the Human Microbiome on Nephrolithiasis |
| title_short | Impact of the Human Microbiome on Nephrolithiasis |
| title_sort | impact of the human microbiome on nephrolithiasis |
| topic | microbiota nephrolithiasis gastrointestinal microbiome |
| url | http://euti.org/upload/pdf/UTI016-02-25.pdf |
| work_keys_str_mv | AT haedojung impactofthehumanmicrobiomeonnephrolithiasis AT jooyonglee impactofthehumanmicrobiomeonnephrolithiasis |