Different administration regimens of compound tropicamide eyedrops for pupil dilation for children with dark iris: a randomized clinical trial
AIM: To compare the efficacy of different administration regimens of compound tropicamide eyedrops (CTE) for pupil dilation for children with dark iris. METHODS: A prospective, comparative, randomized interventional study was conducted. Children in Group 1 received CTE 3 times with a 3min interval b...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Press of International Journal of Ophthalmology (IJO PRESS)
2025-03-01
|
| Series: | International Journal of Ophthalmology |
| Subjects: | |
| Online Access: | http://ies.ijo.cn/en_publish/2025/3/20250307.pdf |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850192749193592832 |
|---|---|
| author | Xu Xu Lian-Xin Zhang Jing-Jing Jiang |
| author_facet | Xu Xu Lian-Xin Zhang Jing-Jing Jiang |
| author_sort | Xu Xu |
| collection | DOAJ |
| description | AIM: To compare the efficacy of different administration regimens of compound tropicamide eyedrops (CTE) for pupil dilation for children with dark iris. METHODS: A prospective, comparative, randomized interventional study was conducted. Children in Group 1 received CTE 3 times with a 3min interval between each application. Children in Group 2 received CTE 4 times with a 5min interval between each application. We measured their pupil diameters at baseline (pre-drug instillation) and 30min and 60min post-drug instillation and assessed the pupillary light reflex at 60min post-drug instillation. RESULTS: In total, 194 eyes of 101 children were enrolled. The changes of pupil diameter at 30min and 60min post-drug instillation were 1.2±0.6 mm and 2.3±1.0 mm in Group 1, and 2.3±0.9 mm and 3.7±1.0 mm in Group 2, respectively. Group 2 showed a larger change in pupil size than Group 1 at 30min (P<0.01) and 60min (P<0.01). The effect of pupil dilation in Group 2 was 1.25 times that in Group 1. The change in pupil size was positively associated with age. A higher proportion of children in Group 1 had smaller pupil diameter and reactive pupils at the final time point, with only 33 children (33.7%) had final pupil size ≥6.5 mm, and only 9 children (9.2%) had non-reactive pupils. Children in Group 2 achieved larger pupil diameter and more non-reactive pupils at the final time point, with 84 children (87.5%) had final pupil size ≥6.5 mm, and only 22 children (22.9%) had reactive pupils. CONCLUSION: Increasing the frequency of compound tropicamide and lengthening the interval between eye drop applications can produce stronger mydriatic effects. |
| format | Article |
| id | doaj-art-56109dc45fbf4309b83704c4e3b68439 |
| institution | OA Journals |
| issn | 2222-3959 2227-4898 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
| record_format | Article |
| series | International Journal of Ophthalmology |
| spelling | doaj-art-56109dc45fbf4309b83704c4e3b684392025-08-20T02:14:27ZengPress of International Journal of Ophthalmology (IJO PRESS)International Journal of Ophthalmology2222-39592227-48982025-03-0118341541910.18240/ijo.2025.03.0720250307Different administration regimens of compound tropicamide eyedrops for pupil dilation for children with dark iris: a randomized clinical trialXu Xu0Lian-Xin Zhang1Jing-Jing Jiang2Jing-Jing Jiang. National Center for Children's Health, MOE Key Laboratory of Major Diseases in Children, Department of Ophthalmology, Beijing Children's Hospital, Capital Medical University, Beijing 100045, China. jiangjingjing@mail.ccmu.edu.cnNational Center for Children's Health, MOE Key Laboratory of Major Diseases in Children, Department of Ophthalmology, Beijing Children's Hospital, Capital Medical University, Beijing 100045, China,National Center for Children's Health, MOE Key Laboratory of Major Diseases in Children, Department of Ophthalmology, Beijing Children's Hospital, Capital Medical University, Beijing 100045, China,AIM: To compare the efficacy of different administration regimens of compound tropicamide eyedrops (CTE) for pupil dilation for children with dark iris. METHODS: A prospective, comparative, randomized interventional study was conducted. Children in Group 1 received CTE 3 times with a 3min interval between each application. Children in Group 2 received CTE 4 times with a 5min interval between each application. We measured their pupil diameters at baseline (pre-drug instillation) and 30min and 60min post-drug instillation and assessed the pupillary light reflex at 60min post-drug instillation. RESULTS: In total, 194 eyes of 101 children were enrolled. The changes of pupil diameter at 30min and 60min post-drug instillation were 1.2±0.6 mm and 2.3±1.0 mm in Group 1, and 2.3±0.9 mm and 3.7±1.0 mm in Group 2, respectively. Group 2 showed a larger change in pupil size than Group 1 at 30min (P<0.01) and 60min (P<0.01). The effect of pupil dilation in Group 2 was 1.25 times that in Group 1. The change in pupil size was positively associated with age. A higher proportion of children in Group 1 had smaller pupil diameter and reactive pupils at the final time point, with only 33 children (33.7%) had final pupil size ≥6.5 mm, and only 9 children (9.2%) had non-reactive pupils. Children in Group 2 achieved larger pupil diameter and more non-reactive pupils at the final time point, with 84 children (87.5%) had final pupil size ≥6.5 mm, and only 22 children (22.9%) had reactive pupils. CONCLUSION: Increasing the frequency of compound tropicamide and lengthening the interval between eye drop applications can produce stronger mydriatic effects.http://ies.ijo.cn/en_publish/2025/3/20250307.pdfpupil dilationmydriasiscompound tropicamidedark irischildren |
| spellingShingle | Xu Xu Lian-Xin Zhang Jing-Jing Jiang Different administration regimens of compound tropicamide eyedrops for pupil dilation for children with dark iris: a randomized clinical trial International Journal of Ophthalmology pupil dilation mydriasis compound tropicamide dark iris children |
| title | Different administration regimens of compound tropicamide eyedrops for pupil dilation for children with dark iris: a randomized clinical trial |
| title_full | Different administration regimens of compound tropicamide eyedrops for pupil dilation for children with dark iris: a randomized clinical trial |
| title_fullStr | Different administration regimens of compound tropicamide eyedrops for pupil dilation for children with dark iris: a randomized clinical trial |
| title_full_unstemmed | Different administration regimens of compound tropicamide eyedrops for pupil dilation for children with dark iris: a randomized clinical trial |
| title_short | Different administration regimens of compound tropicamide eyedrops for pupil dilation for children with dark iris: a randomized clinical trial |
| title_sort | different administration regimens of compound tropicamide eyedrops for pupil dilation for children with dark iris a randomized clinical trial |
| topic | pupil dilation mydriasis compound tropicamide dark iris children |
| url | http://ies.ijo.cn/en_publish/2025/3/20250307.pdf |
| work_keys_str_mv | AT xuxu differentadministrationregimensofcompoundtropicamideeyedropsforpupildilationforchildrenwithdarkirisarandomizedclinicaltrial AT lianxinzhang differentadministrationregimensofcompoundtropicamideeyedropsforpupildilationforchildrenwithdarkirisarandomizedclinicaltrial AT jingjingjiang differentadministrationregimensofcompoundtropicamideeyedropsforpupildilationforchildrenwithdarkirisarandomizedclinicaltrial |