Effect of plasma free fatty acids on lung function in male COPD patients
Abstract Inflammation and oxidative stress play a pivotal role in COPD pathogenesis. Free fatty acids (FFA) as signaling molecules through a series of G-proteins coupled receptors, play an important role in regulation of the immune system and oxidative stress. For this reason, we decided to investig...
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Nature Portfolio
2025-01-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-025-86628-1 |
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| author | Rostam Yazdani Hossein Fallah Shirin Yazdani Beydolah Shahouzehi Behnaz Danesh |
| author_facet | Rostam Yazdani Hossein Fallah Shirin Yazdani Beydolah Shahouzehi Behnaz Danesh |
| author_sort | Rostam Yazdani |
| collection | DOAJ |
| description | Abstract Inflammation and oxidative stress play a pivotal role in COPD pathogenesis. Free fatty acids (FFA) as signaling molecules through a series of G-proteins coupled receptors, play an important role in regulation of the immune system and oxidative stress. For this reason, we decided to investigate the profile of FFA in the plasma in the COPD patients. This is a case-control study comparing 40 male patients with COPD and 40 healthy controls. Biochemical plasma parameters were measured by Autoanalyzer, Malondialdehyde by TBA, total antioxidant capacity via FRAP method and the concentration of free fatty acids were measured by gas chromatography. Then the relationship between the data and the spirometric findings of the patients was determined. In male COPD patients, fasting glucose, myristic acid, palmitic acid, stearic acid, oleic acid, elaidic acid, linoleic acid, linolenic acid and total FFA showed a significant difference with the control group. Also, a positive correlation between the medium chain FFA and lung function was observed. The results of the present study showed that the concentration of different free fatty acids is different in healthy people and male COPD patients, and these differences, especially in the case of medium and long chain fatty acids, can be related to the lung function. |
| format | Article |
| id | doaj-art-560b14848e634861929cea31fad62488 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-560b14848e634861929cea31fad624882025-02-02T12:21:42ZengNature PortfolioScientific Reports2045-23222025-01-0115111110.1038/s41598-025-86628-1Effect of plasma free fatty acids on lung function in male COPD patientsRostam Yazdani0Hossein Fallah1Shirin Yazdani2Beydolah Shahouzehi3Behnaz Danesh4Department of Internal Medicine, Afzalipour Faculty of Medicine, Afzalipour Hospital Research Center, Kerman University of Medical SciencesApplied Cellular and Molecular Research Center, Kerman University of Medical SciencesDepartment of Biomedical Physiology and Kinesiology, Faculty of Science, Simon Fraser UniversityCardiovascular Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical SciencesDepartment of Internal Medicine, Afzalipour Faculty of Medicine, Afzalipour Hospital Research Center, Kerman University of Medical SciencesAbstract Inflammation and oxidative stress play a pivotal role in COPD pathogenesis. Free fatty acids (FFA) as signaling molecules through a series of G-proteins coupled receptors, play an important role in regulation of the immune system and oxidative stress. For this reason, we decided to investigate the profile of FFA in the plasma in the COPD patients. This is a case-control study comparing 40 male patients with COPD and 40 healthy controls. Biochemical plasma parameters were measured by Autoanalyzer, Malondialdehyde by TBA, total antioxidant capacity via FRAP method and the concentration of free fatty acids were measured by gas chromatography. Then the relationship between the data and the spirometric findings of the patients was determined. In male COPD patients, fasting glucose, myristic acid, palmitic acid, stearic acid, oleic acid, elaidic acid, linoleic acid, linolenic acid and total FFA showed a significant difference with the control group. Also, a positive correlation between the medium chain FFA and lung function was observed. The results of the present study showed that the concentration of different free fatty acids is different in healthy people and male COPD patients, and these differences, especially in the case of medium and long chain fatty acids, can be related to the lung function.https://doi.org/10.1038/s41598-025-86628-1COPDFree fatty acidsInflammationOxidative stressSpirometriy |
| spellingShingle | Rostam Yazdani Hossein Fallah Shirin Yazdani Beydolah Shahouzehi Behnaz Danesh Effect of plasma free fatty acids on lung function in male COPD patients Scientific Reports COPD Free fatty acids Inflammation Oxidative stress Spirometriy |
| title | Effect of plasma free fatty acids on lung function in male COPD patients |
| title_full | Effect of plasma free fatty acids on lung function in male COPD patients |
| title_fullStr | Effect of plasma free fatty acids on lung function in male COPD patients |
| title_full_unstemmed | Effect of plasma free fatty acids on lung function in male COPD patients |
| title_short | Effect of plasma free fatty acids on lung function in male COPD patients |
| title_sort | effect of plasma free fatty acids on lung function in male copd patients |
| topic | COPD Free fatty acids Inflammation Oxidative stress Spirometriy |
| url | https://doi.org/10.1038/s41598-025-86628-1 |
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