Reduced Plasma Nonesterified Fatty Acid Levels and the Advent of an Acute Lung Injury in Mice after Intravenous or Enteral Oleic Acid Administration
Although exerting valuable functions in living organisms, nonesterified fatty acids (NEFAs) can be toxic to cells. Increased blood concentration of oleic acid (OLA) and other fatty acids is detected in many pathological conditions. In sepsis and leptospirosis, high plasma levels of NEFA and low albu...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2012/601032 |
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| author | Cassiano Felippe Gonçalves de Albuquerque Patrícia Burth Mauricio Younes Ibrahim Diogo Gomes Garcia Patrícia Torres Bozza Hugo Caire Castro Faria Neto Mauro Velho Castro Faria |
| author_facet | Cassiano Felippe Gonçalves de Albuquerque Patrícia Burth Mauricio Younes Ibrahim Diogo Gomes Garcia Patrícia Torres Bozza Hugo Caire Castro Faria Neto Mauro Velho Castro Faria |
| author_sort | Cassiano Felippe Gonçalves de Albuquerque |
| collection | DOAJ |
| description | Although exerting valuable functions in living organisms, nonesterified fatty acids (NEFAs) can be toxic to cells. Increased blood concentration of oleic acid (OLA) and other fatty acids is detected in many pathological conditions. In sepsis and leptospirosis, high plasma levels of NEFA and low albumin concentrations are correlated to the disease severity. Surprisingly, 24 h after intravenous or intragastric administration of OLA, main NEFA levels (OLA inclusive) were dose dependently decreased. However, lung injury was detected in intravenously treated mice, and highest dose killed all mice. When administered by the enteral route, OLA was not toxic in any tested conditions. Results indicate that OLA has important regulatory properties on fatty acid metabolism, possibly lowering circulating fatty acid through activation of peroxisome proliferator-activated receptors. The significant reduction in blood NEFA levels detected after OLA enteral administration can contribute to the already known health benefits brought about by unsaturated-fatty-acid-enriched diets. |
| format | Article |
| id | doaj-art-560865dea4f049aab0bd560d67487101 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-560865dea4f049aab0bd560d674871012025-02-03T06:07:20ZengWileyMediators of Inflammation0962-93511466-18612012-01-01201210.1155/2012/601032601032Reduced Plasma Nonesterified Fatty Acid Levels and the Advent of an Acute Lung Injury in Mice after Intravenous or Enteral Oleic Acid AdministrationCassiano Felippe Gonçalves de Albuquerque0Patrícia Burth1Mauricio Younes Ibrahim2Diogo Gomes Garcia3Patrícia Torres Bozza4Hugo Caire Castro Faria Neto5Mauro Velho Castro Faria6Laboratório de Imunofarmacologia, Fundação Oswaldo Cruz, FIOCRUZ, Rio de Janeiro 21040-900, BrazilDepartamento de Biologia Celular e Molecular, Instituto de Biologia, Universidade Federal Fluminense, Niteroi 24020-150, BrazilDepartamento de Medicina Interna, Faculdade de Ciências Medicas, Universidade do Estado do Rio de Janeiro, Rio de Janeiro 20550-900, BrazilLaboratório de Imunofarmacologia, Fundação Oswaldo Cruz, FIOCRUZ, Rio de Janeiro 21040-900, BrazilLaboratório de Imunofarmacologia, Fundação Oswaldo Cruz, FIOCRUZ, Rio de Janeiro 21040-900, BrazilLaboratório de Imunofarmacologia, Fundação Oswaldo Cruz, FIOCRUZ, Rio de Janeiro 21040-900, BrazilDepartamento de Medicina Interna, Faculdade de Ciências Medicas, Universidade do Estado do Rio de Janeiro, Rio de Janeiro 20550-900, BrazilAlthough exerting valuable functions in living organisms, nonesterified fatty acids (NEFAs) can be toxic to cells. Increased blood concentration of oleic acid (OLA) and other fatty acids is detected in many pathological conditions. In sepsis and leptospirosis, high plasma levels of NEFA and low albumin concentrations are correlated to the disease severity. Surprisingly, 24 h after intravenous or intragastric administration of OLA, main NEFA levels (OLA inclusive) were dose dependently decreased. However, lung injury was detected in intravenously treated mice, and highest dose killed all mice. When administered by the enteral route, OLA was not toxic in any tested conditions. Results indicate that OLA has important regulatory properties on fatty acid metabolism, possibly lowering circulating fatty acid through activation of peroxisome proliferator-activated receptors. The significant reduction in blood NEFA levels detected after OLA enteral administration can contribute to the already known health benefits brought about by unsaturated-fatty-acid-enriched diets.http://dx.doi.org/10.1155/2012/601032 |
| spellingShingle | Cassiano Felippe Gonçalves de Albuquerque Patrícia Burth Mauricio Younes Ibrahim Diogo Gomes Garcia Patrícia Torres Bozza Hugo Caire Castro Faria Neto Mauro Velho Castro Faria Reduced Plasma Nonesterified Fatty Acid Levels and the Advent of an Acute Lung Injury in Mice after Intravenous or Enteral Oleic Acid Administration Mediators of Inflammation |
| title | Reduced Plasma Nonesterified Fatty Acid Levels and the Advent of an Acute Lung Injury in Mice after Intravenous or Enteral Oleic Acid Administration |
| title_full | Reduced Plasma Nonesterified Fatty Acid Levels and the Advent of an Acute Lung Injury in Mice after Intravenous or Enteral Oleic Acid Administration |
| title_fullStr | Reduced Plasma Nonesterified Fatty Acid Levels and the Advent of an Acute Lung Injury in Mice after Intravenous or Enteral Oleic Acid Administration |
| title_full_unstemmed | Reduced Plasma Nonesterified Fatty Acid Levels and the Advent of an Acute Lung Injury in Mice after Intravenous or Enteral Oleic Acid Administration |
| title_short | Reduced Plasma Nonesterified Fatty Acid Levels and the Advent of an Acute Lung Injury in Mice after Intravenous or Enteral Oleic Acid Administration |
| title_sort | reduced plasma nonesterified fatty acid levels and the advent of an acute lung injury in mice after intravenous or enteral oleic acid administration |
| url | http://dx.doi.org/10.1155/2012/601032 |
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