Ferroptosis in acute liver Failure: Unraveling the hepcidin-ferroportin axis and therapeutic interventions

Ferroptosis in acute liver Failure: Unraveling the hepcidin-ferroportin axis and therapeutic interventions

Acute liver failure (ALF) represents a critical clinical syndrome marked by massive hepatocyte death and severe functional deterioration. While metabolic dysregulation is a recognized hallmark, the pathophysiological implications of iron metabolism disturbance in ALF progression remain poorly unders...

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Bibliographic Details
Main Authors: Jinyong He, Cong Du, Cuiping Li, Wei Li, Jinlan Qiu, Mingpeng Ma, Yunhao Chen, Qi Zhang
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:Redox Biology
Subjects:
Acute liver failure
Mesenchymal stromal cells
Ferroptosis
Iron metabolism
Hepcidin-ferroportin axis
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231725001703
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