Intracranial closed-loop neuromodulation as an intervention for neuropsychiatric disorders: an overview
Recent technological advances in intracranial brain stimulation have enhanced the potential of neuromodulation for addressing neuropsychiatric disorders. We present a review of the methodology and the preliminary outcomes of the pioneering studies exploring intracranial biomarker detection and close...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2025.1479240/full |
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| author | Jenna Langbein Ujwal Boddeti Weizhen Xie Alexander Ksendzovsky |
| author_facet | Jenna Langbein Ujwal Boddeti Weizhen Xie Alexander Ksendzovsky |
| author_sort | Jenna Langbein |
| collection | DOAJ |
| description | Recent technological advances in intracranial brain stimulation have enhanced the potential of neuromodulation for addressing neuropsychiatric disorders. We present a review of the methodology and the preliminary outcomes of the pioneering studies exploring intracranial biomarker detection and closed-loop neuromodulation to modulate high-symptom severity states in neuropsychiatric disorders. We searched PubMed, Scopus, Web of Science, Embase, and PsycINFO/PsycNet, followed by the reference and citation lists of retrieved articles. This search strategy yielded a total of 583 articles, of which 5 articles met the inclusion criteria, focusing on depression, obsessive-compulsive disorder, post-traumatic stress disorder, and binge eating disorder. We discuss the methodology of biomarker identification, the biomarkers identified, and the preliminary treatment outcomes for closed-loop neuromodulation. Successful biomarker identification hinges on investigating across various setting. Targeted neuromodulation, either directed at the biomarker or within its associated neural network, offers a promising treatment approach. Future research should seek to understand the mechanisms underlying the effects of neuromodulation as well as the long-term viability of these treatment effects across different neuropsychiatric conditions. |
| format | Article |
| id | doaj-art-55fafd4ccf5e4af2adf97da5e1e14c4c |
| institution | Kabale University |
| issn | 1664-0640 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj-art-55fafd4ccf5e4af2adf97da5e1e14c4c2025-01-30T06:22:09ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402025-01-011610.3389/fpsyt.2025.14792401479240Intracranial closed-loop neuromodulation as an intervention for neuropsychiatric disorders: an overviewJenna Langbein0Ujwal Boddeti1Weizhen Xie2Alexander Ksendzovsky3Department of Neurosurgery, School of Medicine, University of Maryland, Baltimore, MD, United StatesDepartment of Neurosurgery, School of Medicine, University of Maryland, Baltimore, MD, United StatesDepartment of Psychology, University of Maryland, College Park, MD, United StatesDepartment of Neurosurgery, School of Medicine, University of Maryland, Baltimore, MD, United StatesRecent technological advances in intracranial brain stimulation have enhanced the potential of neuromodulation for addressing neuropsychiatric disorders. We present a review of the methodology and the preliminary outcomes of the pioneering studies exploring intracranial biomarker detection and closed-loop neuromodulation to modulate high-symptom severity states in neuropsychiatric disorders. We searched PubMed, Scopus, Web of Science, Embase, and PsycINFO/PsycNet, followed by the reference and citation lists of retrieved articles. This search strategy yielded a total of 583 articles, of which 5 articles met the inclusion criteria, focusing on depression, obsessive-compulsive disorder, post-traumatic stress disorder, and binge eating disorder. We discuss the methodology of biomarker identification, the biomarkers identified, and the preliminary treatment outcomes for closed-loop neuromodulation. Successful biomarker identification hinges on investigating across various setting. Targeted neuromodulation, either directed at the biomarker or within its associated neural network, offers a promising treatment approach. Future research should seek to understand the mechanisms underlying the effects of neuromodulation as well as the long-term viability of these treatment effects across different neuropsychiatric conditions.https://www.frontiersin.org/articles/10.3389/fpsyt.2025.1479240/fullclosed loop neuromodulationneuropsychaitric disordersneural circuitneural networkDBS (deep brain stimulation)RNS = responsive neurostimulation |
| spellingShingle | Jenna Langbein Ujwal Boddeti Weizhen Xie Alexander Ksendzovsky Intracranial closed-loop neuromodulation as an intervention for neuropsychiatric disorders: an overview Frontiers in Psychiatry closed loop neuromodulation neuropsychaitric disorders neural circuit neural network DBS (deep brain stimulation) RNS = responsive neurostimulation |
| title | Intracranial closed-loop neuromodulation as an intervention for neuropsychiatric disorders: an overview |
| title_full | Intracranial closed-loop neuromodulation as an intervention for neuropsychiatric disorders: an overview |
| title_fullStr | Intracranial closed-loop neuromodulation as an intervention for neuropsychiatric disorders: an overview |
| title_full_unstemmed | Intracranial closed-loop neuromodulation as an intervention for neuropsychiatric disorders: an overview |
| title_short | Intracranial closed-loop neuromodulation as an intervention for neuropsychiatric disorders: an overview |
| title_sort | intracranial closed loop neuromodulation as an intervention for neuropsychiatric disorders an overview |
| topic | closed loop neuromodulation neuropsychaitric disorders neural circuit neural network DBS (deep brain stimulation) RNS = responsive neurostimulation |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2025.1479240/full |
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