Keratinocyte Function in Normal and Diabetic Wounds and Modulation by FOXO1
Diabetes has a significant and negative impact on wound healing, which involves complex interactions between multiple cell types. Keratinocytes play a crucial role in the healing process by rapidly covering dermal and mucosal wound surfaces to reestablish an epithelial barrier with the outside envir...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2020/3714704 |
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| author | Yulan Wang Dana T. Graves |
| author_facet | Yulan Wang Dana T. Graves |
| author_sort | Yulan Wang |
| collection | DOAJ |
| description | Diabetes has a significant and negative impact on wound healing, which involves complex interactions between multiple cell types. Keratinocytes play a crucial role in the healing process by rapidly covering dermal and mucosal wound surfaces to reestablish an epithelial barrier with the outside environment. Keratinocytes produce multiple factors to promote reepithelialization and produce factors that enhance connective tissue repair through the elaboration of mediators that stimulate angiogenesis and production of connective tissue matrix. Among the factors that keratinocytes produce to aid healing are transforming growth factor-β (TGF-β), vascular endothelial growth factor-A (VEGF-A), connective tissue growth factor (CTGF), and antioxidants. In a diabetic environment, this program is disrupted, and keratinocytes fail to produce growth factors and instead switch to a program that is detrimental to healing. Changes in keratinocyte behavior have been linked to high glucose and advanced glycation end products that alter the activities of the transcription factor, FOXO1. This review examines reepithelialization and factors produced by keratinocytes that upregulate connective tissue healing and angiogenesis and how they are altered by diabetes. |
| format | Article |
| id | doaj-art-55f8a5f8d39c43f9935f568c5b34aafa |
| institution | OA Journals |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-55f8a5f8d39c43f9935f568c5b34aafa2025-08-20T02:04:58ZengWileyJournal of Diabetes Research2314-67452314-67532020-01-01202010.1155/2020/37147043714704Keratinocyte Function in Normal and Diabetic Wounds and Modulation by FOXO1Yulan Wang0Dana T. Graves1State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, 430079 Hubei, ChinaDepartment of Periodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, 19104 Pennsylvania, USADiabetes has a significant and negative impact on wound healing, which involves complex interactions between multiple cell types. Keratinocytes play a crucial role in the healing process by rapidly covering dermal and mucosal wound surfaces to reestablish an epithelial barrier with the outside environment. Keratinocytes produce multiple factors to promote reepithelialization and produce factors that enhance connective tissue repair through the elaboration of mediators that stimulate angiogenesis and production of connective tissue matrix. Among the factors that keratinocytes produce to aid healing are transforming growth factor-β (TGF-β), vascular endothelial growth factor-A (VEGF-A), connective tissue growth factor (CTGF), and antioxidants. In a diabetic environment, this program is disrupted, and keratinocytes fail to produce growth factors and instead switch to a program that is detrimental to healing. Changes in keratinocyte behavior have been linked to high glucose and advanced glycation end products that alter the activities of the transcription factor, FOXO1. This review examines reepithelialization and factors produced by keratinocytes that upregulate connective tissue healing and angiogenesis and how they are altered by diabetes.http://dx.doi.org/10.1155/2020/3714704 |
| spellingShingle | Yulan Wang Dana T. Graves Keratinocyte Function in Normal and Diabetic Wounds and Modulation by FOXO1 Journal of Diabetes Research |
| title | Keratinocyte Function in Normal and Diabetic Wounds and Modulation by FOXO1 |
| title_full | Keratinocyte Function in Normal and Diabetic Wounds and Modulation by FOXO1 |
| title_fullStr | Keratinocyte Function in Normal and Diabetic Wounds and Modulation by FOXO1 |
| title_full_unstemmed | Keratinocyte Function in Normal and Diabetic Wounds and Modulation by FOXO1 |
| title_short | Keratinocyte Function in Normal and Diabetic Wounds and Modulation by FOXO1 |
| title_sort | keratinocyte function in normal and diabetic wounds and modulation by foxo1 |
| url | http://dx.doi.org/10.1155/2020/3714704 |
| work_keys_str_mv | AT yulanwang keratinocytefunctioninnormalanddiabeticwoundsandmodulationbyfoxo1 AT danatgraves keratinocytefunctioninnormalanddiabeticwoundsandmodulationbyfoxo1 |