Ectopic Adrenocorticotropic Hormone–Secreting Metastatic Pancreatic Neuroendocrine Tumor Initially Presenting as Gastrinoma: A Case Report
Pancreatic neuroendocrine tumors (pNETs) account for 1% to 2% of all pancreatic malignancies; approximately one-third are associated with hormone secretion which can result in a range of symptoms. It is rare for pNETs to transform from secreting one type of peptide hormone to another. We present a c...
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| Format: | Article |
| Language: | English |
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American College of Physicians
2024-06-01
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| Series: | Annals of Internal Medicine: Clinical Cases |
| Online Access: | https://www.acpjournals.org/doi/10.7326/aimcc.2023.0925 |
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| author | Harshitha Dudipala Matthew Kulke Sara Meibom Hussein Assi |
| author_facet | Harshitha Dudipala Matthew Kulke Sara Meibom Hussein Assi |
| author_sort | Harshitha Dudipala |
| collection | DOAJ |
| description | Pancreatic neuroendocrine tumors (pNETs) account for 1% to 2% of all pancreatic malignancies; approximately one-third are associated with hormone secretion which can result in a range of symptoms. It is rare for pNETs to transform from secreting one type of peptide hormone to another. We present a case of metastatic pNET that originally presented as a gastrinoma, and later transformed to an ectopic adrenocorticotropic hormone–secreting pNET, treated with bilateral adrenalectomy. We describe the presentation and management of the patient and review the available literature on management of ectopic adrenocorticotropic hormone production in patients with neuroendocrine tumors. |
| format | Article |
| id | doaj-art-55f8570db1424af89255eea742d92d1f |
| institution | DOAJ |
| issn | 2767-7664 |
| language | English |
| publishDate | 2024-06-01 |
| publisher | American College of Physicians |
| record_format | Article |
| series | Annals of Internal Medicine: Clinical Cases |
| spelling | doaj-art-55f8570db1424af89255eea742d92d1f2025-08-20T03:18:45ZengAmerican College of PhysiciansAnnals of Internal Medicine: Clinical Cases2767-76642024-06-013610.7326/aimcc.2023.0925Ectopic Adrenocorticotropic Hormone–Secreting Metastatic Pancreatic Neuroendocrine Tumor Initially Presenting as Gastrinoma: A Case ReportHarshitha Dudipala0Matthew Kulke1Sara Meibom2Hussein Assi31Department of Medicine, Boston University Chobanian and Avedisian School of Medicine and Boston Medical Center, Boston, Massachusetts2Section of Hematology and Medical Oncology, Boston University Chobanian and Avedisian School of Medicine and Boston Medical Center, Boston, Massachusetts3Department of Radiology, Boston University Chobanian and Avedisian School of Medicine and Boston Medical Center, Boston, Massachusetts2Section of Hematology and Medical Oncology, Boston University Chobanian and Avedisian School of Medicine and Boston Medical Center, Boston, MassachusettsPancreatic neuroendocrine tumors (pNETs) account for 1% to 2% of all pancreatic malignancies; approximately one-third are associated with hormone secretion which can result in a range of symptoms. It is rare for pNETs to transform from secreting one type of peptide hormone to another. We present a case of metastatic pNET that originally presented as a gastrinoma, and later transformed to an ectopic adrenocorticotropic hormone–secreting pNET, treated with bilateral adrenalectomy. We describe the presentation and management of the patient and review the available literature on management of ectopic adrenocorticotropic hormone production in patients with neuroendocrine tumors.https://www.acpjournals.org/doi/10.7326/aimcc.2023.0925 |
| spellingShingle | Harshitha Dudipala Matthew Kulke Sara Meibom Hussein Assi Ectopic Adrenocorticotropic Hormone–Secreting Metastatic Pancreatic Neuroendocrine Tumor Initially Presenting as Gastrinoma: A Case Report Annals of Internal Medicine: Clinical Cases |
| title | Ectopic Adrenocorticotropic Hormone–Secreting Metastatic Pancreatic Neuroendocrine Tumor Initially Presenting as Gastrinoma: A Case Report |
| title_full | Ectopic Adrenocorticotropic Hormone–Secreting Metastatic Pancreatic Neuroendocrine Tumor Initially Presenting as Gastrinoma: A Case Report |
| title_fullStr | Ectopic Adrenocorticotropic Hormone–Secreting Metastatic Pancreatic Neuroendocrine Tumor Initially Presenting as Gastrinoma: A Case Report |
| title_full_unstemmed | Ectopic Adrenocorticotropic Hormone–Secreting Metastatic Pancreatic Neuroendocrine Tumor Initially Presenting as Gastrinoma: A Case Report |
| title_short | Ectopic Adrenocorticotropic Hormone–Secreting Metastatic Pancreatic Neuroendocrine Tumor Initially Presenting as Gastrinoma: A Case Report |
| title_sort | ectopic adrenocorticotropic hormone secreting metastatic pancreatic neuroendocrine tumor initially presenting as gastrinoma a case report |
| url | https://www.acpjournals.org/doi/10.7326/aimcc.2023.0925 |
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