Evaluation of Nutritional Supplements on Periodontal Fibroblast in Systemic Disease Conditions: An In Vitro Study
Background: Periodontal health is influenced by various systemic factors, including nutritional status. Nutritional supplements have been proposed to improve periodontal health, particularly in individuals with systemic diseases. Materials and Methods: This in vitro interventional study aimed to eva...
Saved in:
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2024-12-01
|
| Series: | Journal of Pharmacy and Bioallied Sciences |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/jpbs.jpbs_1177_24 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | Background:
Periodontal health is influenced by various systemic factors, including nutritional status. Nutritional supplements have been proposed to improve periodontal health, particularly in individuals with systemic diseases.
Materials and Methods:
This in vitro interventional study aimed to evaluate the effects of nutritional supplements on periodontal health in systemic disease conditions. Human gingival fibroblast cells were cultured under conditions mimicking systemic diseases such as diabetes mellitus and cardiovascular disease. The cells were treated with different nutritional supplements commonly used in periodontal therapy, including vitamin C, vitamin D, omega-3 fatty acids, and probiotics. The effects of these supplements on cell viability, inflammatory response, and extracellular matrix production were assessed using various assays and molecular techniques.
Results:
Treatment with nutritional supplements led to improvements in cell viability, reduction in inflammatory cytokine expression, and enhanced extracellular matrix synthesis in gingival fibroblast cells under systemic disease conditions. Specifically, vitamin C and omega-3 fatty acids demonstrated significant protective effects against inflammation-induced cell damage, while probiotics promoted a balanced immune response.
Conclusion:
Nutritional supplements, including vitamin C, vitamin D, omega-3 fatty acids, and probiotics, exhibit promising effects on periodontal health in systemic disease conditions. These supplements may serve as adjunctive therapeutic options for managing periodontal disease in individuals with systemic comorbidities. |
|---|---|
| ISSN: | 0976-4879 0975-7406 |