Analysis of electroencephalography oscillation characteristics in spinal cord injury patients with neuropathic pain
Objectives: To investigate the electroencephalography (EEG) features in patients with spinal cord injury (SCI) experiencing neuropathic pain (NP) by analyzing the γ (30–80 Hz) frequency band. Methods: Participants were divided into three groups: the PWP group (SCI patients with pain), the PNP group...
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Elsevier
2025-09-01
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| Series: | Brain Research Bulletin |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0361923025002503 |
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| author | Dezheng Wang Xinting Zhang Shouwei Yue Dongju Guo Lei Jiang Chao Feng Jiancai Leng Shaolei Huang Yang Zhang Fangzhou Xu |
| author_facet | Dezheng Wang Xinting Zhang Shouwei Yue Dongju Guo Lei Jiang Chao Feng Jiancai Leng Shaolei Huang Yang Zhang Fangzhou Xu |
| author_sort | Dezheng Wang |
| collection | DOAJ |
| description | Objectives: To investigate the electroencephalography (EEG) features in patients with spinal cord injury (SCI) experiencing neuropathic pain (NP) by analyzing the γ (30–80 Hz) frequency band. Methods: Participants were divided into three groups: the PWP group (SCI patients with pain), the PNP group (SCI patients without pain) and AB group (able-bodied). Then we recorded and preprocessed the EEG data and calculated the power spectral density (PSD). Then, the amplitude of γ band oscillation (GBO) and the strength of brain network connections among the different groups were compared. Results: In the PWP group, early GBO was observed in the FPZ channel in the resting state, and the main effect was concentrated in the 55–60 Hz range. In the high-frequency γ band (55–80 Hz) of the FPZ channel, the PWP group showed a higher GBO than the other groups. Moreover, during motor imagination (MI), the PWP group showed significantly stronger functional connectivity than the AB group, but significantly weaker than the PNP group. Conclusion: The GBO related to NP is highly consistent with the frequency domain manifestations of chronic pain. NP causes persistent abnormal increases in the γ-band PSD in multiple brain regions and the GBO changes in the prefrontal cortex have the strongest correlation with NP symptoms. |
| format | Article |
| id | doaj-art-55f0bf8947004cb1910edd0e58d9d086 |
| institution | DOAJ |
| issn | 1873-2747 |
| language | English |
| publishDate | 2025-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brain Research Bulletin |
| spelling | doaj-art-55f0bf8947004cb1910edd0e58d9d0862025-08-20T02:49:20ZengElsevierBrain Research Bulletin1873-27472025-09-0122911143810.1016/j.brainresbull.2025.111438Analysis of electroencephalography oscillation characteristics in spinal cord injury patients with neuropathic painDezheng Wang0Xinting Zhang1Shouwei Yue2Dongju Guo3Lei Jiang4Chao Feng5Jiancai Leng6Shaolei Huang7Yang Zhang8Fangzhou Xu9Rehabilitation and Physical Therapy Department, Shandong University of Traditional Chinese Medicine Affiliated Hospital, NO.42, Wenhuaxi Road, Jinan, Shandong, China; Rehabilitation Center, Qilu Hospital of Shandong University, Jinan, Shandong, ChinaDepartment of Pediatrics, Qilu Hospital of Shandong University, Jinan, Shandong, ChinaRehabilitation Center, Qilu Hospital of Shandong University, Jinan, Shandong, ChinaRehabilitation Center, Qilu Hospital of Shandong University, Jinan, Shandong, ChinaRehabilitation and Physical Therapy Department, Shandong University of Traditional Chinese Medicine Affiliated Hospital, NO.42, Wenhuaxi Road, Jinan, Shandong, ChinaInternational School for Optoelectronic Engineering, Qilu University of Technology (Shandong Academy of Sciences), Jinan, ChinaInternational School for Optoelectronic Engineering, Qilu University of Technology (Shandong Academy of Sciences), Jinan, ChinaAcupuncture and Moxibustion Department, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, ChinaRehabilitation and Physical Therapy Department, Shandong University of Traditional Chinese Medicine Affiliated Hospital, NO.42, Wenhuaxi Road, Jinan, Shandong, China; Corresponding authors.International School for Optoelectronic Engineering, Qilu University of Technology (Shandong Academy of Sciences), Jinan, China; Corresponding authors.Objectives: To investigate the electroencephalography (EEG) features in patients with spinal cord injury (SCI) experiencing neuropathic pain (NP) by analyzing the γ (30–80 Hz) frequency band. Methods: Participants were divided into three groups: the PWP group (SCI patients with pain), the PNP group (SCI patients without pain) and AB group (able-bodied). Then we recorded and preprocessed the EEG data and calculated the power spectral density (PSD). Then, the amplitude of γ band oscillation (GBO) and the strength of brain network connections among the different groups were compared. Results: In the PWP group, early GBO was observed in the FPZ channel in the resting state, and the main effect was concentrated in the 55–60 Hz range. In the high-frequency γ band (55–80 Hz) of the FPZ channel, the PWP group showed a higher GBO than the other groups. Moreover, during motor imagination (MI), the PWP group showed significantly stronger functional connectivity than the AB group, but significantly weaker than the PNP group. Conclusion: The GBO related to NP is highly consistent with the frequency domain manifestations of chronic pain. NP causes persistent abnormal increases in the γ-band PSD in multiple brain regions and the GBO changes in the prefrontal cortex have the strongest correlation with NP symptoms.http://www.sciencedirect.com/science/article/pii/S0361923025002503Spinal cord injuryNeuropathic painElectroencephalography (EEG) detectionγ band oscillationBiomarkerMotor imagination |
| spellingShingle | Dezheng Wang Xinting Zhang Shouwei Yue Dongju Guo Lei Jiang Chao Feng Jiancai Leng Shaolei Huang Yang Zhang Fangzhou Xu Analysis of electroencephalography oscillation characteristics in spinal cord injury patients with neuropathic pain Brain Research Bulletin Spinal cord injury Neuropathic pain Electroencephalography (EEG) detection γ band oscillation Biomarker Motor imagination |
| title | Analysis of electroencephalography oscillation characteristics in spinal cord injury patients with neuropathic pain |
| title_full | Analysis of electroencephalography oscillation characteristics in spinal cord injury patients with neuropathic pain |
| title_fullStr | Analysis of electroencephalography oscillation characteristics in spinal cord injury patients with neuropathic pain |
| title_full_unstemmed | Analysis of electroencephalography oscillation characteristics in spinal cord injury patients with neuropathic pain |
| title_short | Analysis of electroencephalography oscillation characteristics in spinal cord injury patients with neuropathic pain |
| title_sort | analysis of electroencephalography oscillation characteristics in spinal cord injury patients with neuropathic pain |
| topic | Spinal cord injury Neuropathic pain Electroencephalography (EEG) detection γ band oscillation Biomarker Motor imagination |
| url | http://www.sciencedirect.com/science/article/pii/S0361923025002503 |
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