Human birth tissue products as a non-opioid medicine to inhibit post-surgical pain

Human birth tissue products as a non-opioid medicine to inhibit post-surgical pain

Pain after surgery causes significant suffering. Opioid analgesics cause severe side effects and accidental death. Therefore, there is an urgent need to develop non-opioid therapies for managing post-surgical pain. Local application of Clarix Flo (FLO), a human amniotic membrane (AM) product, attenu...

Full description

Saved in:
Bibliographic Details
Main Authors: Chi Zhang, Qian Huang, Neil C Ford, Nathachit Limjunyawong, Qing Lin, Fei Yang, Xiang Cui, Ankit Uniyal, Jing Liu, Megha Mahabole, Hua He, Xuewei Wang, Irina Duff, Yiru Wang, Jieru Wan, Guangwu Zhu, Srinivasa N Raja, Hongpeng Jia, Dazhi Yang, Xinzhong Dong, Xu Cao, Scheffer C Tseng, Shaoqiu He, Yun Guan
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2024-12-01
Series:eLife
Subjects:
pain
human birth tissues
sensory neurons
CD44
cytoskeleton rearrangement
Online Access:https://elifesciences.org/articles/101269
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Pain after surgery causes significant suffering. Opioid analgesics cause severe side effects and accidental death. Therefore, there is an urgent need to develop non-opioid therapies for managing post-surgical pain. Local application of Clarix Flo (FLO), a human amniotic membrane (AM) product, attenuated established post-surgical pain hypersensitivity without exhibiting known side effects of opioid use in mice. This effect was achieved through direct inhibition of nociceptive dorsal root ganglion (DRG) neurons via CD44-dependent pathways. We further purified the major matrix component, the heavy chain-hyaluronic acid/pentraxin 3 (HC-HA/PTX3) from human AM that has greater purity and water solubility than FLO. HC-HA/PTX3 replicated FLO-induced neuronal and pain inhibition. Mechanistically, HC-HA/PTX3-induced cytoskeleton rearrangements to inhibit sodium current and high-voltage activated calcium current on nociceptive DRG neurons, suggesting it is a key bioactive component mediating pain relief. Collectively, our findings highlight the potential of naturally derived biologics from human birth tissues as an effective non-opioid treatment for post-surgical pain. Moreover, we unravel the underlying neuronal mechanisms of pain inhibition induced by FLO and HC-HA/PTX3.
ISSN:2050-084X

Similar Items