Effects of otolaryngological diseases on sleep quality, anxiety, and depression: a multicenter observational study
Abstract Background The impact of otolaryngological diseases on sleep quality, anxiety, and depression has garnered significant attention. However, research has primarily focused on unveiling the effects of only one or two specific diseases, without analyzing the impact of multiple concurrent diseas...
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BMC
2025-02-01
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| Series: | BMC Psychiatry |
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| Online Access: | https://doi.org/10.1186/s12888-025-06531-x |
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| author | Cheng-Lin Qi Qin-Ying Wang Mi Wang Lin-Bin Cai Meng-Qing Shen Kan Liu Jin-Long Zhu Cong Wang Qi-Bing Chen Ting-Ting Wu Shui-Hong Zhou Jin-Hua Pan |
| author_facet | Cheng-Lin Qi Qin-Ying Wang Mi Wang Lin-Bin Cai Meng-Qing Shen Kan Liu Jin-Long Zhu Cong Wang Qi-Bing Chen Ting-Ting Wu Shui-Hong Zhou Jin-Hua Pan |
| author_sort | Cheng-Lin Qi |
| collection | DOAJ |
| description | Abstract Background The impact of otolaryngological diseases on sleep quality, anxiety, and depression has garnered significant attention. However, research has primarily focused on unveiling the effects of only one or two specific diseases, without analyzing the impact of multiple concurrent diseases. Furthermore, investigation into the interaction mechanisms among these factors has been lacking. Objectives This study reveals the effects of different otolaryngological diseases on sleep quality, anxiety, and depression, and investigates their interaction mechanisms. Methods In total, 2,080 patients with otolaryngological diseases were recruited from six centers in mainland China. Data on sociodemographics, history of smoking and alcohol consumption, diagnosis, anxiety, depression, and sleep quality were collected through hospital information system queries and questionnaires. We uncovered the psychological status and sleep quality of otolaryngology outpatients with different diseases and revealed the interaction mechanisms between these diseases and anxiety, depression, and sleep quality. Multivariable polynomial linear regression models explored the impact of different otolaryngological diseases on anxiety, depression and sleep quality, and mediation analysis explored the interaction mechanisms. Results Chronic laryngitis, eustachian tube disorders, laryngeal swelling, laryngopharyngeal reflux, neck lymphatic inflammation, snoring, sudden deafness, tinnitus, nasopharyngeal lesions, and trauma had a significant impact on Pittsburgh Sleep Quality Index scores. Chronic tonsillitis, chronic laryngitis, and laryngopharyngeal reflux had a significant impact on Zung Self-Rating Depression Scale scores. Patients with giddiness (P = 0.006) and tinnitus (P = 0.006) tended to have higher Zung Self-Rating Anxiety Scale scores. Anxiety mediated the effect of tinnitus on sleep quality (70.41%; 95% confidence interval [CI]: 40.07, 76.00), and depression also had a mediation effect (13.24%; 95% CI: 4.46, 28.58). Other diseases also exhibited mediating effects and interactions with anxiety, depression, and sleep quality. Conclusions Sleep quality significantly mediates the relationships of specific otolaryngological diseases with anxiety and depression. Similarly, anxiety and depression play important mediating roles in the relationships of different diseases with sleep quality. By revealing the interactive effects of different otolaryngological diseases on anxiety, depression, and sleep quality, this study could aid early interventions aiming to reduce anxiety and depression and improve patients’ sleep quality and quality of life. |
| format | Article |
| id | doaj-art-55d748a8ca274e5eba5c3701ca3b1375 |
| institution | DOAJ |
| issn | 1471-244X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Psychiatry |
| spelling | doaj-art-55d748a8ca274e5eba5c3701ca3b13752025-08-20T02:48:12ZengBMCBMC Psychiatry1471-244X2025-02-0125111210.1186/s12888-025-06531-xEffects of otolaryngological diseases on sleep quality, anxiety, and depression: a multicenter observational studyCheng-Lin Qi0Qin-Ying Wang1Mi Wang2Lin-Bin Cai3Meng-Qing Shen4Kan Liu5Jin-Long Zhu6Cong Wang7Qi-Bing Chen8Ting-Ting Wu9Shui-Hong Zhou10Jin-Hua Pan11Department of Otolaryngology, The First Affiliated Hospital, Zhejiang University School of MedicineDepartment of Otolaryngology, The First Affiliated Hospital, Zhejiang University School of MedicineDepartment of Otolaryngology, The First Affiliated Hospital, Zhejiang University School of MedicineDepartment of Otolaryngology, The First Affiliated Hospital, Zhejiang University School of MedicineDepartment of Otolaryngology, The First Affiliated Hospital, Zhejiang University School of MedicineDepartment of Otolaryngology, Zhejiang Xin’an International HospitalDepartment of Otolaryngology, Shaoxing Second HospitalDepartment of Otolaryngology, The First Affiliated Hospital, Zhejiang University School of MedicineDepartment of Otolaryngology, The First Affiliated Hospital, Zhejiang University School of MedicineDepartment of Otolaryngology, The First Affiliated Hospital, Zhejiang University School of MedicineDepartment of Otolaryngology, The First Affiliated Hospital, Zhejiang University School of MedicineDepartment of Ultrasound Medicine, The First Affiliated Hospital, Zhejiang University School of MedicineAbstract Background The impact of otolaryngological diseases on sleep quality, anxiety, and depression has garnered significant attention. However, research has primarily focused on unveiling the effects of only one or two specific diseases, without analyzing the impact of multiple concurrent diseases. Furthermore, investigation into the interaction mechanisms among these factors has been lacking. Objectives This study reveals the effects of different otolaryngological diseases on sleep quality, anxiety, and depression, and investigates their interaction mechanisms. Methods In total, 2,080 patients with otolaryngological diseases were recruited from six centers in mainland China. Data on sociodemographics, history of smoking and alcohol consumption, diagnosis, anxiety, depression, and sleep quality were collected through hospital information system queries and questionnaires. We uncovered the psychological status and sleep quality of otolaryngology outpatients with different diseases and revealed the interaction mechanisms between these diseases and anxiety, depression, and sleep quality. Multivariable polynomial linear regression models explored the impact of different otolaryngological diseases on anxiety, depression and sleep quality, and mediation analysis explored the interaction mechanisms. Results Chronic laryngitis, eustachian tube disorders, laryngeal swelling, laryngopharyngeal reflux, neck lymphatic inflammation, snoring, sudden deafness, tinnitus, nasopharyngeal lesions, and trauma had a significant impact on Pittsburgh Sleep Quality Index scores. Chronic tonsillitis, chronic laryngitis, and laryngopharyngeal reflux had a significant impact on Zung Self-Rating Depression Scale scores. Patients with giddiness (P = 0.006) and tinnitus (P = 0.006) tended to have higher Zung Self-Rating Anxiety Scale scores. Anxiety mediated the effect of tinnitus on sleep quality (70.41%; 95% confidence interval [CI]: 40.07, 76.00), and depression also had a mediation effect (13.24%; 95% CI: 4.46, 28.58). Other diseases also exhibited mediating effects and interactions with anxiety, depression, and sleep quality. Conclusions Sleep quality significantly mediates the relationships of specific otolaryngological diseases with anxiety and depression. Similarly, anxiety and depression play important mediating roles in the relationships of different diseases with sleep quality. By revealing the interactive effects of different otolaryngological diseases on anxiety, depression, and sleep quality, this study could aid early interventions aiming to reduce anxiety and depression and improve patients’ sleep quality and quality of life.https://doi.org/10.1186/s12888-025-06531-xOtolaryngological diseasesAnxietyDepressionSleep quality |
| spellingShingle | Cheng-Lin Qi Qin-Ying Wang Mi Wang Lin-Bin Cai Meng-Qing Shen Kan Liu Jin-Long Zhu Cong Wang Qi-Bing Chen Ting-Ting Wu Shui-Hong Zhou Jin-Hua Pan Effects of otolaryngological diseases on sleep quality, anxiety, and depression: a multicenter observational study BMC Psychiatry Otolaryngological diseases Anxiety Depression Sleep quality |
| title | Effects of otolaryngological diseases on sleep quality, anxiety, and depression: a multicenter observational study |
| title_full | Effects of otolaryngological diseases on sleep quality, anxiety, and depression: a multicenter observational study |
| title_fullStr | Effects of otolaryngological diseases on sleep quality, anxiety, and depression: a multicenter observational study |
| title_full_unstemmed | Effects of otolaryngological diseases on sleep quality, anxiety, and depression: a multicenter observational study |
| title_short | Effects of otolaryngological diseases on sleep quality, anxiety, and depression: a multicenter observational study |
| title_sort | effects of otolaryngological diseases on sleep quality anxiety and depression a multicenter observational study |
| topic | Otolaryngological diseases Anxiety Depression Sleep quality |
| url | https://doi.org/10.1186/s12888-025-06531-x |
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