FGF21 Is Associated with Acanthosis Nigricans in Obese Patients
Objective. We aimed to investigate the relationship between FGF21 and obesity-related acanthosis nigricans (AN). Methods. 40 obese patients without AN (OB group), 40 obese patients with AN (AN group), and 40 healthy volunteers (control group, CON) were included in this study. Weight, BMI, lipid prof...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2016/1658062 |
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| author | Yueye Huang Jie Yang Yan Li Jiaqi Chen Kexiu Song Xingchun Wang Le Bu Xiaoyun Cheng Jiying Wang Shen Qu |
| author_facet | Yueye Huang Jie Yang Yan Li Jiaqi Chen Kexiu Song Xingchun Wang Le Bu Xiaoyun Cheng Jiying Wang Shen Qu |
| author_sort | Yueye Huang |
| collection | DOAJ |
| description | Objective. We aimed to investigate the relationship between FGF21 and obesity-related acanthosis nigricans (AN). Methods. 40 obese patients without AN (OB group), 40 obese patients with AN (AN group), and 40 healthy volunteers (control group, CON) were included in this study. Weight, BMI, lipid profile, FFA, UA, and CRP were measured in all participants. Oral glucose tolerance tests (OGTT) were performed and serum glucose and plasma insulin were measured. Serum FGF21 was measured by ELISA. Results. Compared with OB group, AN group had higher levels of fasting insulin and homeostasis model of assessment for insulin resistance (HOMA-IR) (P<0.05), but lower serum levels of blood glucose. The difference of FGF21 among three groups was significant and AN group showed the highest serum level of FGF21 (P<0.05). Serum FGF21 was most positively correlated with fasting insulin and HOMA-IR. Multiple logistic analysis showed that FGF21 was the independent risk factor for AN (OR 4.550; 95% CI 1.054–19.635; P=0.042). Conclusion. AN patients had more serious hyperinsulinemia but better serum levels of blood glucose than OB. Increased FGF21 is associated with AN in obese patients and may be considered as compensatory response to the decreased insulin sensitivity. |
| format | Article |
| id | doaj-art-55d69fb3b20c4cdca0552226fd3f2809 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-55d69fb3b20c4cdca0552226fd3f28092025-02-03T01:01:49ZengWileyInternational Journal of Endocrinology1687-83371687-83452016-01-01201610.1155/2016/16580621658062FGF21 Is Associated with Acanthosis Nigricans in Obese PatientsYueye Huang0Jie Yang1Yan Li2Jiaqi Chen3Kexiu Song4Xingchun Wang5Le Bu6Xiaoyun Cheng7Jiying Wang8Shen Qu9Department of Endocrinology and Metabolism, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai 200072, ChinaDepartment of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai 200433, ChinaDepartment of Endocrinology and Metabolism, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai 200072, ChinaDepartment of Endocrinology and Metabolism, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai 200072, ChinaDepartment of Endocrinology and Metabolism, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai 200072, ChinaDepartment of Endocrinology and Metabolism, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai 200072, ChinaDepartment of Endocrinology and Metabolism, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai 200072, ChinaDepartment of Endocrinology and Metabolism, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai 200072, ChinaDepartment of Endocrinology and Metabolism, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai 200072, ChinaDepartment of Endocrinology and Metabolism, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai 200072, ChinaObjective. We aimed to investigate the relationship between FGF21 and obesity-related acanthosis nigricans (AN). Methods. 40 obese patients without AN (OB group), 40 obese patients with AN (AN group), and 40 healthy volunteers (control group, CON) were included in this study. Weight, BMI, lipid profile, FFA, UA, and CRP were measured in all participants. Oral glucose tolerance tests (OGTT) were performed and serum glucose and plasma insulin were measured. Serum FGF21 was measured by ELISA. Results. Compared with OB group, AN group had higher levels of fasting insulin and homeostasis model of assessment for insulin resistance (HOMA-IR) (P<0.05), but lower serum levels of blood glucose. The difference of FGF21 among three groups was significant and AN group showed the highest serum level of FGF21 (P<0.05). Serum FGF21 was most positively correlated with fasting insulin and HOMA-IR. Multiple logistic analysis showed that FGF21 was the independent risk factor for AN (OR 4.550; 95% CI 1.054–19.635; P=0.042). Conclusion. AN patients had more serious hyperinsulinemia but better serum levels of blood glucose than OB. Increased FGF21 is associated with AN in obese patients and may be considered as compensatory response to the decreased insulin sensitivity.http://dx.doi.org/10.1155/2016/1658062 |
| spellingShingle | Yueye Huang Jie Yang Yan Li Jiaqi Chen Kexiu Song Xingchun Wang Le Bu Xiaoyun Cheng Jiying Wang Shen Qu FGF21 Is Associated with Acanthosis Nigricans in Obese Patients International Journal of Endocrinology |
| title | FGF21 Is Associated with Acanthosis Nigricans in Obese Patients |
| title_full | FGF21 Is Associated with Acanthosis Nigricans in Obese Patients |
| title_fullStr | FGF21 Is Associated with Acanthosis Nigricans in Obese Patients |
| title_full_unstemmed | FGF21 Is Associated with Acanthosis Nigricans in Obese Patients |
| title_short | FGF21 Is Associated with Acanthosis Nigricans in Obese Patients |
| title_sort | fgf21 is associated with acanthosis nigricans in obese patients |
| url | http://dx.doi.org/10.1155/2016/1658062 |
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