Synthetic Biology Innovations in Designing Cellulose-Based Smart Drug Delivery Systems
The integration of synthetic biology with cellulose-based materials has paved the way for groundbreaking advancements in smart drug release and delivery systems. Synthetic biology, through precise genetic engineering and the creation of programmable biological circuits, enables the development of dr...
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| Format: | Article |
| Language: | English |
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North Carolina State University
2025-05-01
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| Series: | BioResources |
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| Online Access: | https://ojs.bioresources.com/index.php/BRJ/article/view/24451 |
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| author | Samy Selim Mohammed S. Almuhayawi Soad K. Al Jaouni Mohammad Harun-Ur-Rashid |
| author_facet | Samy Selim Mohammed S. Almuhayawi Soad K. Al Jaouni Mohammad Harun-Ur-Rashid |
| author_sort | Samy Selim |
| collection | DOAJ |
| description | The integration of synthetic biology with cellulose-based materials has paved the way for groundbreaking advancements in smart drug release and delivery systems. Synthetic biology, through precise genetic engineering and the creation of programmable biological circuits, enables the development of drug carriers that can respond dynamically to specific physiological cues, such as pH changes. For example, the contrast in pH between the stomach (pH ~1.5 to 3.5) and the intestines (pH ~6 to 7.5) has been exploited in cellulose-based systems to achieve site-specific drug release. Cellulose offers an ideal platform for constructing these responsive drug delivery systems. This review explores recent innovations in genetically engineered cellulose, functionalization strategies via synthetic biology, and advanced biofabrication techniques such as 3D bioprinting and microfluidics. Applications of these systems span cancer therapeutics, antimicrobial treatments, chronic disease management, and emerging areas like personalized medicine and gene therapy. Challenges related to biocompatibility, scalability, and regulatory approval persist. Future directions involving CRISPR-Cas9-mediated cellulose modification, machine learning for optimized drug release, and sustainable production strategies highlight the transformative potential of these systems in precision medicine. This review provides comprehensive insights into the current state and future prospects of cellulose-based smart drug delivery, offering a roadmap for advancing next-generation therapeutics. |
| format | Article |
| id | doaj-art-55d0d21dcba543949643eb3e3d71d25f |
| institution | OA Journals |
| issn | 1930-2126 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | North Carolina State University |
| record_format | Article |
| series | BioResources |
| spelling | doaj-art-55d0d21dcba543949643eb3e3d71d25f2025-08-20T02:13:48ZengNorth Carolina State UniversityBioResources1930-21262025-05-01202510151133084Synthetic Biology Innovations in Designing Cellulose-Based Smart Drug Delivery SystemsSamy Selim0https://orcid.org/0000-0003-4025-8586Mohammed S. Almuhayawi1https://orcid.org/0000-0002-4792-066XSoad K. Al Jaouni2https://orcid.org/0000-0003-0602-0224Mohammad Harun-Ur-Rashid3https://orcid.org/0000-0003-1883-4620Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Jouf University, Sakaka 72388, Saudi Arabia Department of Clinical Microbiology and Immunology, Faculty of Medicine, King Abdulaziz University, Jeddah 21589, Saudi ArabiaDepartment of Hematology/Oncology, Yousef Abdulatif Jameel Scientific Chair of Prophetic Medicine Application, Faculty of Medicine, King Abdulaziz University, Jeddah 21589, Saudi ArabiaDepartment of Chemistry, International University of Business Agriculture and Technology (IUBAT), Sector 10, Uttara Model Town, Uttara, Dhaka 1230, BangladeshThe integration of synthetic biology with cellulose-based materials has paved the way for groundbreaking advancements in smart drug release and delivery systems. Synthetic biology, through precise genetic engineering and the creation of programmable biological circuits, enables the development of drug carriers that can respond dynamically to specific physiological cues, such as pH changes. For example, the contrast in pH between the stomach (pH ~1.5 to 3.5) and the intestines (pH ~6 to 7.5) has been exploited in cellulose-based systems to achieve site-specific drug release. Cellulose offers an ideal platform for constructing these responsive drug delivery systems. This review explores recent innovations in genetically engineered cellulose, functionalization strategies via synthetic biology, and advanced biofabrication techniques such as 3D bioprinting and microfluidics. Applications of these systems span cancer therapeutics, antimicrobial treatments, chronic disease management, and emerging areas like personalized medicine and gene therapy. Challenges related to biocompatibility, scalability, and regulatory approval persist. Future directions involving CRISPR-Cas9-mediated cellulose modification, machine learning for optimized drug release, and sustainable production strategies highlight the transformative potential of these systems in precision medicine. This review provides comprehensive insights into the current state and future prospects of cellulose-based smart drug delivery, offering a roadmap for advancing next-generation therapeutics.https://ojs.bioresources.com/index.php/BRJ/article/view/24451 synthetic biologycellulose-based drug deliverysmart drug delivery systemsgenetically engineered cellulosestimuli-responsive drug releasebiofabrication techniquespersonalized medicinecrispr-cas9 functionalization |
| spellingShingle | Samy Selim Mohammed S. Almuhayawi Soad K. Al Jaouni Mohammad Harun-Ur-Rashid Synthetic Biology Innovations in Designing Cellulose-Based Smart Drug Delivery Systems BioResources synthetic biology cellulose-based drug delivery smart drug delivery systems genetically engineered cellulose stimuli-responsive drug release biofabrication techniques personalized medicine crispr-cas9 functionalization |
| title | Synthetic Biology Innovations in Designing Cellulose-Based Smart Drug Delivery Systems |
| title_full | Synthetic Biology Innovations in Designing Cellulose-Based Smart Drug Delivery Systems |
| title_fullStr | Synthetic Biology Innovations in Designing Cellulose-Based Smart Drug Delivery Systems |
| title_full_unstemmed | Synthetic Biology Innovations in Designing Cellulose-Based Smart Drug Delivery Systems |
| title_short | Synthetic Biology Innovations in Designing Cellulose-Based Smart Drug Delivery Systems |
| title_sort | synthetic biology innovations in designing cellulose based smart drug delivery systems |
| topic | synthetic biology cellulose-based drug delivery smart drug delivery systems genetically engineered cellulose stimuli-responsive drug release biofabrication techniques personalized medicine crispr-cas9 functionalization |
| url | https://ojs.bioresources.com/index.php/BRJ/article/view/24451 |
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