Current Advances and Challenges in CAR-T Therapy for Hematological and Solid Tumors
Gengtian Zhang,1,* Mengyao Bai,1,* Hanzhi Du,2 Yue Yuan,2 Yidan Wang,2 Weijing Fan,3 Huachao Zhu,2 Di Wu,2 Pengcheng He,2 Busheng Xue2 1Health Science Center, Xi’an Jiaotong University, Xi’an, 710061, People’s Republic of China; 2Department of Hematology, The First Affiliated...
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| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2025-06-01
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| Series: | ImmunoTargets and Therapy |
| Subjects: | |
| Online Access: | https://www.dovepress.com/current-advances-and-challenges-in-car-t-therapy-for-hematological-and-peer-reviewed-fulltext-article-ITT |
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| Summary: | Gengtian Zhang,1,* Mengyao Bai,1,* Hanzhi Du,2 Yue Yuan,2 Yidan Wang,2 Weijing Fan,3 Huachao Zhu,2 Di Wu,2 Pengcheng He,2 Busheng Xue2 1Health Science Center, Xi’an Jiaotong University, Xi’an, 710061, People’s Republic of China; 2Department of Hematology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, 710061, People’s Republic of China; 3Department of Radiation Oncology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, 710061, People’s Republic of China*These authors contributed equally to this workCorrespondence: Pengcheng He, Department of Hematology, The First Affiliated Hospital of Xi’an Jiaotong University, No. 277, Yanta District, Xi’an, 710061, People’s Republic of China, Email hepecheng@xjtu.edu.cn Busheng Xue, Department of Hematology, The First Affiliated Hospital of Xi’an Jiaotong University, No. 277, Yanta District, Xi’an, 710061, People’s Republic of China, Email bushengxue@xjtufh.edu.cnIntroduction: Chimeric antigen receptor (CAR) T-cell therapy has revolutionized the treatment of refractory hematological malignancies, yet significant challenges persist in extending its success to solid tumors. This review aims to provide a comprehensive overview of the current landscape and future perspectives of CAR-T therapy in both hematological malignancies and solid tumors.Methods: A thorough literature search was conducted to identify relevant preclinical and clinical studies, as well as review articles, focusing on CAR-T therapy in various hematological malignancies and solid tumors. The collected information was synthesized to discuss the current applications, challenges, and strategies for improving CAR-T therapy in these settings.Results: CAR-T therapy has demonstrated impressive clinical outcomes in treating certain hematological malignancies, such as B-cell lymphoma, leukemia, and multiple myeloma. However, the efficacy of CAR-T cells in solid tumors has been limited due to various obstacles, including tumor heterogeneity, immunosuppressive microenvironment, and off-tumor toxicities. Strategies to overcome these challenges involve advanced CAR designs, combination therapies, and novel approaches to CAR-T cell manufacturing and engineering.Conclusion: While CAR-T therapy has revolutionized the treatment of some hematological malignancies, significant hurdles remain in extending its success to solid tumors. Continued research efforts focusing on improving CAR-T cell efficacy, safety, and accessibility will be crucial in unlocking the full potential of this innovative immunotherapeutic approach across a broad spectrum of cancer types.Keywords: CAR-T, hematological malignancies, solid tumors, translational advances, clinical challenges |
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| ISSN: | 2253-1556 |