Metabolic Alterations of Short-Chain Organic Acids in the Elderly Link Antibiotic Exposure with the Risk for Depression
Background: Our previous study showed that antibiotic exposure was linked to depressive symptomatology in community-dwelling older adults in China. Our current study aims to explore the underlying mechanisms by assessing the intermediated effects of circulating short-chain organic acids (SCOAs) on t...
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2024-12-01
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| author | Shujing Sun Li Kong Fangting Hu Sheng Wang Menglong Geng Hongjuan Cao Xingyong Tao Fangbiao Tao Kaiyong Liu |
| author_facet | Shujing Sun Li Kong Fangting Hu Sheng Wang Menglong Geng Hongjuan Cao Xingyong Tao Fangbiao Tao Kaiyong Liu |
| author_sort | Shujing Sun |
| collection | DOAJ |
| description | Background: Our previous study showed that antibiotic exposure was linked to depressive symptomatology in community-dwelling older adults in China. Our current study aims to explore the underlying mechanisms by assessing the intermediated effects of circulating short-chain organic acids (SCOAs) on this association. Methods: Depressive symptoms were screened by the 30-item Geriatric Depression Scale (GDS-30). Urinary concentrations of antibiotics and serum SCOAs were measured using a liquid chromatography–mass spectrometry method. Results: Increased exposure to sulfadiazine, azithromycin, tetracyclines, or veterinary antibiotics (VAs) was positively associated with GDS-30 scores. Tetracycline reduced levels of caproic acid, iso-butyric acid, and iso-caproic acid (iso-CA), with iso-CA concentration inversely correlating with GDS-30 scores, while β-hydroxybutyric acids showed a positive correlation. The mediating effect of serum iso-CA on the association between depression and ofloxacin, with a mediating effect of 25.3%, and the association between depression and tetracycline, with a mediating effect of 46.3%, were both statistically significant, indicating partial mediation. Conclusions: Antibiotics may affect the levels of SCOAs in older adults and could potentially contribute to depressive symptoms by influencing alterations in serum iso-CA levels. |
| format | Article |
| id | doaj-art-55ce4c71ed47450c853bebf2f7350272 |
| institution | DOAJ |
| issn | 2218-1989 |
| language | English |
| publishDate | 2024-12-01 |
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| series | Metabolites |
| spelling | doaj-art-55ce4c71ed47450c853bebf2f73502722025-08-20T02:50:41ZengMDPI AGMetabolites2218-19892024-12-01141268910.3390/metabo14120689Metabolic Alterations of Short-Chain Organic Acids in the Elderly Link Antibiotic Exposure with the Risk for DepressionShujing Sun0Li Kong1Fangting Hu2Sheng Wang3Menglong Geng4Hongjuan Cao5Xingyong Tao6Fangbiao Tao7Kaiyong Liu8School of Public Health, Anhui Medical University, No. 81 Meishan Road, Hefei 230032, ChinaSchool of Public Health, Anhui Medical University, No. 81 Meishan Road, Hefei 230032, ChinaSchool of Public Health, Anhui Medical University, No. 81 Meishan Road, Hefei 230032, ChinaCenter for Scientific Research, Anhui Medical University, No. 81 Meishan Road, Hefei 230032, ChinaSchool of Public Health, Anhui Medical University, No. 81 Meishan Road, Hefei 230032, ChinaLu’an Center of Disease Control and Prevention, Lu’an 237000, ChinaSchool of Public Health, Anhui Medical University, No. 81 Meishan Road, Hefei 230032, ChinaSchool of Public Health, Anhui Medical University, No. 81 Meishan Road, Hefei 230032, ChinaSchool of Public Health, Anhui Medical University, No. 81 Meishan Road, Hefei 230032, ChinaBackground: Our previous study showed that antibiotic exposure was linked to depressive symptomatology in community-dwelling older adults in China. Our current study aims to explore the underlying mechanisms by assessing the intermediated effects of circulating short-chain organic acids (SCOAs) on this association. Methods: Depressive symptoms were screened by the 30-item Geriatric Depression Scale (GDS-30). Urinary concentrations of antibiotics and serum SCOAs were measured using a liquid chromatography–mass spectrometry method. Results: Increased exposure to sulfadiazine, azithromycin, tetracyclines, or veterinary antibiotics (VAs) was positively associated with GDS-30 scores. Tetracycline reduced levels of caproic acid, iso-butyric acid, and iso-caproic acid (iso-CA), with iso-CA concentration inversely correlating with GDS-30 scores, while β-hydroxybutyric acids showed a positive correlation. The mediating effect of serum iso-CA on the association between depression and ofloxacin, with a mediating effect of 25.3%, and the association between depression and tetracycline, with a mediating effect of 46.3%, were both statistically significant, indicating partial mediation. Conclusions: Antibiotics may affect the levels of SCOAs in older adults and could potentially contribute to depressive symptoms by influencing alterations in serum iso-CA levels.https://www.mdpi.com/2218-1989/14/12/689antibioticsbiomonitoringdepressive symptomsshort-chain organic acidsthe elderly |
| spellingShingle | Shujing Sun Li Kong Fangting Hu Sheng Wang Menglong Geng Hongjuan Cao Xingyong Tao Fangbiao Tao Kaiyong Liu Metabolic Alterations of Short-Chain Organic Acids in the Elderly Link Antibiotic Exposure with the Risk for Depression Metabolites antibiotics biomonitoring depressive symptoms short-chain organic acids the elderly |
| title | Metabolic Alterations of Short-Chain Organic Acids in the Elderly Link Antibiotic Exposure with the Risk for Depression |
| title_full | Metabolic Alterations of Short-Chain Organic Acids in the Elderly Link Antibiotic Exposure with the Risk for Depression |
| title_fullStr | Metabolic Alterations of Short-Chain Organic Acids in the Elderly Link Antibiotic Exposure with the Risk for Depression |
| title_full_unstemmed | Metabolic Alterations of Short-Chain Organic Acids in the Elderly Link Antibiotic Exposure with the Risk for Depression |
| title_short | Metabolic Alterations of Short-Chain Organic Acids in the Elderly Link Antibiotic Exposure with the Risk for Depression |
| title_sort | metabolic alterations of short chain organic acids in the elderly link antibiotic exposure with the risk for depression |
| topic | antibiotics biomonitoring depressive symptoms short-chain organic acids the elderly |
| url | https://www.mdpi.com/2218-1989/14/12/689 |
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