Structure-function relationship of ASH1L and histone H3K36 and H3K4 methylation

Structure-function relationship of ASH1L and histone H3K36 and H3K4 methylation

Abstract The histone H3K36-specific methyltransferase ASH1L plays a critical role in development and is frequently dysregulated in human diseases, particularly cancer. Here, we report on the biological functions of the C-terminal region of ASH1L encompassing a bromodomain (ASH1LBD), a plant homeodom...

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Main Authors: Kendra R. Vann, Rajal Sharma, Chih-Chao Hsu, Maeva Devoucoux, Adam H. Tencer, Lei Zeng, Kevin Lin, Li Zhu, Qin Li, Catherine Lachance, Ruben Rosas Ospina, Qiong Tong, Ka Lung Cheung, Shuai Yang, Soumi Biswas, Hongwen Xuan, Jovylyn Gatchalian, Lorena Alamillo, Jianlong Wang, Suk Min Jang, Brianna J. Klein, Yue Lu, Patricia Ernst, Brian D. Strahl, Scott B. Rothbart, Martin J. Walsh, Michael L. Cleary, Jacques Côté, Xiaobing Shi, Ming-Ming Zhou, Tatiana G. Kutateladze
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-57556-5
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