Syncope and All-Cause Mortality in Heart Failure: A Propensity Score–Matched Analysis
Objective: To examine the association between syncope and all-cause mortality in a large cohort of patients with heart failure (HF) with syncope. Patients and Methods: We retrospectively identified a cohort of patients with HF and syncope from January 1, 2010, to December 31, 2015, and matched them...
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Elsevier
2025-06-01
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| Series: | Mayo Clinic Proceedings: Innovations, Quality & Outcomes |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2542454825000311 |
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| author | Pattara Rattanawong, MD Chieh-Ju Chao, MD Anil Sriramoju, MD Cecilia Tagle-Cornell, MS Juan Maria M. Farina, MD Ellen Beirne, MBBS Marlene E. Girardo, MS Laura M. Koepke, MSN Olubadewa A. Fatunde, MD, MPH Nway L. Ko Ko, MBBS Win-Kuang Shen, MD |
| author_facet | Pattara Rattanawong, MD Chieh-Ju Chao, MD Anil Sriramoju, MD Cecilia Tagle-Cornell, MS Juan Maria M. Farina, MD Ellen Beirne, MBBS Marlene E. Girardo, MS Laura M. Koepke, MSN Olubadewa A. Fatunde, MD, MPH Nway L. Ko Ko, MBBS Win-Kuang Shen, MD |
| author_sort | Pattara Rattanawong, MD |
| collection | DOAJ |
| description | Objective: To examine the association between syncope and all-cause mortality in a large cohort of patients with heart failure (HF) with syncope. Patients and Methods: We retrospectively identified a cohort of patients with HF and syncope from January 1, 2010, to December 31, 2015, and matched them in a 1:1 propensity analysis with patients with HF without syncope. A multivariable Cox regression model was used to estimate the association between syncope and the end point, all-cause mortality. Results: During the study period, 3449 patients with HF were diagnosed with syncope (mean ± SD age, 72.8±14.3 years). At 12 months follow-up, syncope was not an independent risk factor of all-cause mortality in overall patients with HF (hazard ratio [HR], 0.98; 95% CI, 0.91-1.04; P=.467), HF with preserved ejection fraction (EF) (HR, 1.02; 95% CI, 0.93-1.11; P=.686), HF with mid-range EF (HR, 0.92; 95% CI, 0.73-1.16; P=.494), or HF with reduced EF (HR, 0.94; 95% CI, 0.83-1.06; P=284). In the subgroup of those with cardiac implantable electronic devices, syncope significantly increased the risk of all-cause mortality in HF with reduced EF (HR, 1.28; 95% CI, 1.01-1.62; P=.038). Conclusion: Syncope was not an independent risk of all-cause mortality for patients with HF but significantly predicted the all-cause mortality in the subgroup of patients with heart failure reduced EF with cardiac implantable electronic devices. |
| format | Article |
| id | doaj-art-55cd7af979944a2b8f4e1f96d4879eb1 |
| institution | OA Journals |
| issn | 2542-4548 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Mayo Clinic Proceedings: Innovations, Quality & Outcomes |
| spelling | doaj-art-55cd7af979944a2b8f4e1f96d4879eb12025-08-20T02:33:55ZengElsevierMayo Clinic Proceedings: Innovations, Quality & Outcomes2542-45482025-06-019310062010.1016/j.mayocpiqo.2025.100620Syncope and All-Cause Mortality in Heart Failure: A Propensity Score–Matched AnalysisPattara Rattanawong, MD0Chieh-Ju Chao, MD1Anil Sriramoju, MD2Cecilia Tagle-Cornell, MS3Juan Maria M. Farina, MD4Ellen Beirne, MBBS5Marlene E. Girardo, MS6Laura M. Koepke, MSN7Olubadewa A. Fatunde, MD, MPH8Nway L. Ko Ko, MBBS9Win-Kuang Shen, MD10Department of Cardiovascular Medicine, Mayo Clinic, Phoenix, AZDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MNDepartment of Internal Medicine, University of North Dakota, Grand Forks, ND; Department of Cardiovascular Medicine (limited tenure), Mayo Clinic, Phoenix, AZDepartment of Cardiovascular Medicine, Mayo Clinic, Phoenix, AZDepartment of Cardiovascular Medicine, Mayo Clinic, Phoenix, AZ; Department of Cardiovascular Medicine, Mayo Clinic School of Graduate Medical Education, Mayo Clinic College of Medicine and Science, Scottsdale, AZDepartment of Cardiovascular Medicine, Mayo Clinic School of Graduate Medical Education, Mayo Clinic College of Medicine and Science, Scottsdale, AZDepartment of Cardiovascular Medicine, Mayo Clinic, Phoenix, AZ; Division of Clinical Trials and Biostatistics, Mayo Clinic, Phoenix, AZDepartment of Cardiovascular Medicine, Mayo Clinic, Phoenix, AZDepartment of Cardiovascular Medicine, Mayo Clinic School of Graduate Medical Education, Mayo Clinic College of Medicine and Science, Scottsdale, AZDepartment of Cardiovascular Medicine, Mayo Clinic School of Graduate Medical Education, Mayo Clinic College of Medicine and Science, Scottsdale, AZDepartment of Cardiovascular Medicine, Mayo Clinic, Phoenix, AZ; Correspondence: Address to Win-Kuang Shen, MD, Department of Cardiovascular Medicine, Mayo Clinic, 5777 E Mayo Blvd, Phoenix, AZ 85054.Objective: To examine the association between syncope and all-cause mortality in a large cohort of patients with heart failure (HF) with syncope. Patients and Methods: We retrospectively identified a cohort of patients with HF and syncope from January 1, 2010, to December 31, 2015, and matched them in a 1:1 propensity analysis with patients with HF without syncope. A multivariable Cox regression model was used to estimate the association between syncope and the end point, all-cause mortality. Results: During the study period, 3449 patients with HF were diagnosed with syncope (mean ± SD age, 72.8±14.3 years). At 12 months follow-up, syncope was not an independent risk factor of all-cause mortality in overall patients with HF (hazard ratio [HR], 0.98; 95% CI, 0.91-1.04; P=.467), HF with preserved ejection fraction (EF) (HR, 1.02; 95% CI, 0.93-1.11; P=.686), HF with mid-range EF (HR, 0.92; 95% CI, 0.73-1.16; P=.494), or HF with reduced EF (HR, 0.94; 95% CI, 0.83-1.06; P=284). In the subgroup of those with cardiac implantable electronic devices, syncope significantly increased the risk of all-cause mortality in HF with reduced EF (HR, 1.28; 95% CI, 1.01-1.62; P=.038). Conclusion: Syncope was not an independent risk of all-cause mortality for patients with HF but significantly predicted the all-cause mortality in the subgroup of patients with heart failure reduced EF with cardiac implantable electronic devices.http://www.sciencedirect.com/science/article/pii/S2542454825000311 |
| spellingShingle | Pattara Rattanawong, MD Chieh-Ju Chao, MD Anil Sriramoju, MD Cecilia Tagle-Cornell, MS Juan Maria M. Farina, MD Ellen Beirne, MBBS Marlene E. Girardo, MS Laura M. Koepke, MSN Olubadewa A. Fatunde, MD, MPH Nway L. Ko Ko, MBBS Win-Kuang Shen, MD Syncope and All-Cause Mortality in Heart Failure: A Propensity Score–Matched Analysis Mayo Clinic Proceedings: Innovations, Quality & Outcomes |
| title | Syncope and All-Cause Mortality in Heart Failure: A Propensity Score–Matched Analysis |
| title_full | Syncope and All-Cause Mortality in Heart Failure: A Propensity Score–Matched Analysis |
| title_fullStr | Syncope and All-Cause Mortality in Heart Failure: A Propensity Score–Matched Analysis |
| title_full_unstemmed | Syncope and All-Cause Mortality in Heart Failure: A Propensity Score–Matched Analysis |
| title_short | Syncope and All-Cause Mortality in Heart Failure: A Propensity Score–Matched Analysis |
| title_sort | syncope and all cause mortality in heart failure a propensity score matched analysis |
| url | http://www.sciencedirect.com/science/article/pii/S2542454825000311 |
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