Engrafted NSG-SGM3 humanized mice spontaneously produce human immunoglobulins including IgE

Engrafted NSG-SGM3 humanized mice spontaneously produce human immunoglobulins including IgE

NSG-SGM3 humanized mouse models are well-suited for studying human immune physiology but are technically challenging and expensive. We previously characterized a simplified NSG-SGM3 mouse, engrafted with human donor CD34+ hematopoietic stem cells without receiving prior bone marrow ablation or human...

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Bibliographic Details
Main Authors: Erica V. Lin, Rebecca A. Krier-Burris, Kristina A. Sokol, Betania Arce, Natalia M. Vilela, Robert G. Hamilton, Bruce S. Bochner, Melanie C. Dispenza
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Immunology
Subjects:
anaphylaxis
B cell
humanized mice
IgE
NSG-SGM3
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1628194/full
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