Mendelian randomization analysis of modifiable risk factors for breast cancer
Abstract This review explores the role of Mendelian randomization (MR) in the analysis of modifiable risk factors for breast cancer. Breast cancer is the most common cancer in women, with risk factors including lifestyle, genetic predisposition, and hormonal influences. Mendelian randomization (MR)...
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| Format: | Article |
| Language: | English |
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Springer
2025-06-01
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| Series: | Discover Oncology |
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| Online Access: | https://doi.org/10.1007/s12672-025-02412-7 |
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| author | Diabate Ousmane Jie Liu Ziyu Liu Zongjiang Zhou Liu Liu Junpu Wang |
| author_facet | Diabate Ousmane Jie Liu Ziyu Liu Zongjiang Zhou Liu Liu Junpu Wang |
| author_sort | Diabate Ousmane |
| collection | DOAJ |
| description | Abstract This review explores the role of Mendelian randomization (MR) in the analysis of modifiable risk factors for breast cancer. Breast cancer is the most common cancer in women, with risk factors including lifestyle, genetic predisposition, and hormonal influences. Mendelian randomization (MR) is a robust epidemiological tool, uses genetic variants to assess causal relationships between exposures and breast cancer risk. Evidence suggests that obesity, particularly in adulthood, is associated with elevated risk, while early obesity may be protective. Alcohol consumption shows a complex relationship, with adverse effects associated with problematic drinking behaviors rather than moderate drinking. Physical activity is associated with reduced breast cancer risk, likely through hormonal and metabolic pathways. Dietary factors, such as higher intake of monounsaturated fatty acids and vitamin E, appear protective, highlighting the importance of dietary choices. Methodological considerations, including pleiotropy and sample size, are crucial to ensure the validity of MR studies. Overall, this synthesis of existing studies demonstrates the importance of Mendelian randomization (MR) in identifying causal links between modifiable risk factors and breast cancer, which is essential for developing targeted prevention strategies. |
| format | Article |
| id | doaj-art-55b98bda32aa4069a51c24f3959c4e30 |
| institution | DOAJ |
| issn | 2730-6011 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Springer |
| record_format | Article |
| series | Discover Oncology |
| spelling | doaj-art-55b98bda32aa4069a51c24f3959c4e302025-08-20T03:22:50ZengSpringerDiscover Oncology2730-60112025-06-0116111010.1007/s12672-025-02412-7Mendelian randomization analysis of modifiable risk factors for breast cancerDiabate Ousmane0Jie Liu1Ziyu Liu2Zongjiang Zhou3Liu Liu4Junpu Wang5Department of Pathology, Xiangya Hospital, Central South UniversityDepartment of Pathology, Xiangya Hospital, Central South UniversityDepartment of Pathology, Xiangya Hospital, Central South UniversityDepartment of Pathology, Xiangya Hospital, Central South UniversityFuRong LaboratoryDepartment of Pathology, Xiangya Hospital, Central South UniversityAbstract This review explores the role of Mendelian randomization (MR) in the analysis of modifiable risk factors for breast cancer. Breast cancer is the most common cancer in women, with risk factors including lifestyle, genetic predisposition, and hormonal influences. Mendelian randomization (MR) is a robust epidemiological tool, uses genetic variants to assess causal relationships between exposures and breast cancer risk. Evidence suggests that obesity, particularly in adulthood, is associated with elevated risk, while early obesity may be protective. Alcohol consumption shows a complex relationship, with adverse effects associated with problematic drinking behaviors rather than moderate drinking. Physical activity is associated with reduced breast cancer risk, likely through hormonal and metabolic pathways. Dietary factors, such as higher intake of monounsaturated fatty acids and vitamin E, appear protective, highlighting the importance of dietary choices. Methodological considerations, including pleiotropy and sample size, are crucial to ensure the validity of MR studies. Overall, this synthesis of existing studies demonstrates the importance of Mendelian randomization (MR) in identifying causal links between modifiable risk factors and breast cancer, which is essential for developing targeted prevention strategies.https://doi.org/10.1007/s12672-025-02412-7Mendelian randomization (MR)Breast cancerModifiable risk factorsObesityBody mass index (BMI)Alcohol consumption |
| spellingShingle | Diabate Ousmane Jie Liu Ziyu Liu Zongjiang Zhou Liu Liu Junpu Wang Mendelian randomization analysis of modifiable risk factors for breast cancer Discover Oncology Mendelian randomization (MR) Breast cancer Modifiable risk factors Obesity Body mass index (BMI) Alcohol consumption |
| title | Mendelian randomization analysis of modifiable risk factors for breast cancer |
| title_full | Mendelian randomization analysis of modifiable risk factors for breast cancer |
| title_fullStr | Mendelian randomization analysis of modifiable risk factors for breast cancer |
| title_full_unstemmed | Mendelian randomization analysis of modifiable risk factors for breast cancer |
| title_short | Mendelian randomization analysis of modifiable risk factors for breast cancer |
| title_sort | mendelian randomization analysis of modifiable risk factors for breast cancer |
| topic | Mendelian randomization (MR) Breast cancer Modifiable risk factors Obesity Body mass index (BMI) Alcohol consumption |
| url | https://doi.org/10.1007/s12672-025-02412-7 |
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