Cardioprotective effects of dapagliflozin against the acute cardiotoxic effects of 5-fluorouracil

Cardioprotective effects of dapagliflozin against the acute cardiotoxic effects of 5-fluorouracil

Background5-Fluorouracil (5-FU) has potential cardiotoxic effects, including direct cardiomyocyte damage, arrhythmia development, and coronary vasospasm. Numerous studies have demonstrated that dapagliflozin (DAPA) possesses cardioprotective properties. Theoretically, DAPA may have the potential to...

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Bibliographic Details
Main Authors: Mehmet Hakan Uzun, Sebahat Ulusan, Afragül Yönet, Kadir Şeker, Murat Sevimli, Kanat Gülle, Adnan Karaibrahimoğlu, Aliye Kuyumcu, Selçuk Kanat, Mehmet Alagöz, Mevlüt Serdar Kuyumcu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
5-fluorouracil
cardiotoxicity
heart failure
SGLT2 inhibitors
cardiomyopathy
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2025.1633420/full
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