PERSONALIZED STATIN THERAPY IN IMPROVING THE TREATMENT OF CORONARY ARTERY DISEASE AND ATHEROSCLEROSIS

PERSONALIZED STATIN THERAPY IN IMPROVING THE TREATMENT OF CORONARY ARTERY DISEASE AND ATHEROSCLEROSIS

This review examines the possibility of personalized pharmacotherapy with statins, based on the genotype of the individual patient. Identification of polymorphism of genes, responsible for the metabolism of the liver CYP3A5, CYP2C9 and transport of statins into the liver SLCO1B1, BCRP allows differe...

Full description

Saved in:
Bibliographic Details
Main Authors: U. R. Makhmudova, Sh. U. Hoshimov, G. J. Abdullayeva, A. B. Shek, R. D. Kurbanov
Format: Article
Language:Russian
Published: InterMedservice 2015-06-01
Series:Евразийский Кардиологический Журнал
Subjects:
статины
полиморфизмы генов метаболизма печени
персонализированная фармакотерапия
statins
hepatic metabolism genes polymorphisms
personalized pharmacotherapy
Online Access:https://www.heartj.asia/jour/article/view/5635
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:This review examines the possibility of personalized pharmacotherapy with statins, based on the genotype of the individual patient. Identification of polymorphism of genes, responsible for the metabolism of the liver CYP3A5, CYP2C9 and transport of statins into the liver SLCO1B1, BCRP allows differentiated approach to their appointment and choice. This will not only increase the effectiveness of statins, but also to avoid serious side effects, primarily statin-induced myopathy and toxic hepatitis.
ISSN:2225-1685
2305-0748

Similar Items