Effect of perampanel in reducing depression in patients with focal epilepsy

Abstracts: Background: High prevalence of depression is very common in epilepsy. This study aimed to discover the effect of perampanel on depression in patients with focal epilepsy. Methods: This is a prospective observational study. We included a total of 68 patients with focal EP, which were trea...

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Main Authors: Min Ming, Long Chen, Jian Huang, Ying Huang, Jiali Yin
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:IBRO Neuroscience Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2667242125000077
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author Min Ming
Long Chen
Jian Huang
Ying Huang
Jiali Yin
author_facet Min Ming
Long Chen
Jian Huang
Ying Huang
Jiali Yin
author_sort Min Ming
collection DOAJ
description Abstracts: Background: High prevalence of depression is very common in epilepsy. This study aimed to discover the effect of perampanel on depression in patients with focal epilepsy. Methods: This is a prospective observational study. We included a total of 68 patients with focal EP, which were treated with perampanel. We analyzed data before perampanel treatment and at 6 and 12 months of follow-up of the optimal dose. Using the Beck Depression Inventory-II (BDI-II) scale to evaluate depression, the Mini-Mental State Examination (MMSE) to assess the cognitive function, and the Quality of Life in Epilepsy-31 items (QOLIE-31) to estimate the quality of life of EP patients. Results: The BDI-II score improved significantly compared to before treatment and at 6 and 12 months of follow-up (P < 0.001). The mean total QOLIE-31 score significantly increased from 82.9 ± 20.4 to 88.7 ± 21.2 at the 12-month follow-up (P < 0.001). In addition, seizure control was improved significantly at 12 months: 32.1 % of patients were seizure-free, and 73.2 % were responsive. Moreover, there was statistical relationship between improvement in depression and seizure control. The MMSE score was not different before and after treatment (P > 0.05). Multiple Regression Analysis was found that annual family income, etiology, the frequency of attacks in recent years, types of ASMs and the age were the influence factors of pirampanel in reducing depression (P<0.05). Conclusion: Perampanel reduced depression symptoms in patients with focal epilepsy, although the lack of a control group or the relatively small sample size.
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spelling doaj-art-55b0e22632d9452bb2b74ca5908fb5832025-01-29T05:02:22ZengElsevierIBRO Neuroscience Reports2667-24212025-06-0118257262Effect of perampanel in reducing depression in patients with focal epilepsyMin Ming0Long Chen1Jian Huang2Ying Huang3Jiali Yin4Department of Neurology, the First Affiliated Hospital of Gannan Medical University, ChinaDepartment of Neurology, Jinshan Hospital, Fudan University, ChinaThe First Clinical college of Gannan Medical UniversityDepartment of Neurology, Jinshan Hospital, Fudan University, China; Corresponding authors.Department of Neurology, the First Affiliated Hospital of Gannan Medical University, China; Corresponding authors.Abstracts: Background: High prevalence of depression is very common in epilepsy. This study aimed to discover the effect of perampanel on depression in patients with focal epilepsy. Methods: This is a prospective observational study. We included a total of 68 patients with focal EP, which were treated with perampanel. We analyzed data before perampanel treatment and at 6 and 12 months of follow-up of the optimal dose. Using the Beck Depression Inventory-II (BDI-II) scale to evaluate depression, the Mini-Mental State Examination (MMSE) to assess the cognitive function, and the Quality of Life in Epilepsy-31 items (QOLIE-31) to estimate the quality of life of EP patients. Results: The BDI-II score improved significantly compared to before treatment and at 6 and 12 months of follow-up (P < 0.001). The mean total QOLIE-31 score significantly increased from 82.9 ± 20.4 to 88.7 ± 21.2 at the 12-month follow-up (P < 0.001). In addition, seizure control was improved significantly at 12 months: 32.1 % of patients were seizure-free, and 73.2 % were responsive. Moreover, there was statistical relationship between improvement in depression and seizure control. The MMSE score was not different before and after treatment (P > 0.05). Multiple Regression Analysis was found that annual family income, etiology, the frequency of attacks in recent years, types of ASMs and the age were the influence factors of pirampanel in reducing depression (P<0.05). Conclusion: Perampanel reduced depression symptoms in patients with focal epilepsy, although the lack of a control group or the relatively small sample size.http://www.sciencedirect.com/science/article/pii/S2667242125000077
spellingShingle Min Ming
Long Chen
Jian Huang
Ying Huang
Jiali Yin
Effect of perampanel in reducing depression in patients with focal epilepsy
IBRO Neuroscience Reports
title Effect of perampanel in reducing depression in patients with focal epilepsy
title_full Effect of perampanel in reducing depression in patients with focal epilepsy
title_fullStr Effect of perampanel in reducing depression in patients with focal epilepsy
title_full_unstemmed Effect of perampanel in reducing depression in patients with focal epilepsy
title_short Effect of perampanel in reducing depression in patients with focal epilepsy
title_sort effect of perampanel in reducing depression in patients with focal epilepsy
url http://www.sciencedirect.com/science/article/pii/S2667242125000077
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AT jianhuang effectofperampanelinreducingdepressioninpatientswithfocalepilepsy
AT yinghuang effectofperampanelinreducingdepressioninpatientswithfocalepilepsy
AT jialiyin effectofperampanelinreducingdepressioninpatientswithfocalepilepsy