From urea to urea cocrystals: A critical view of conventional and emerging nitrogenous fertilizer materials for improved environmental sustainability

Nitrogen (N) is a critical nutrient that is essential for plant growth and sustainable population development. Since the inception of modern fertilizer technology, N has been supplied to the environment via low-stability fertilizer materials which has resulted in very large losses of reactive nitrog...

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Main Authors: Mohamed Eisa, Mariana Brondi, Clinton Williams, Reagan Hejl, Jonas Baltrusaitis
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:Sustainable Chemistry for the Environment
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Online Access:http://www.sciencedirect.com/science/article/pii/S2949839225000045
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author Mohamed Eisa
Mariana Brondi
Clinton Williams
Reagan Hejl
Jonas Baltrusaitis
author_facet Mohamed Eisa
Mariana Brondi
Clinton Williams
Reagan Hejl
Jonas Baltrusaitis
author_sort Mohamed Eisa
collection DOAJ
description Nitrogen (N) is a critical nutrient that is essential for plant growth and sustainable population development. Since the inception of modern fertilizer technology, N has been supplied to the environment via low-stability fertilizer materials which has resulted in very large losses of reactive nitrogen to the environment. These losses have severe impacts on soil, air and surface water locally and result in changes to the ecosystem biodiversity as well as climate globally. Synthesis of nitrogen fertilizer, such as urea, consumes 1–2 % of global energy as well as significant amounts of natural gas. Therefore, it is necessary to improve the stability of fertilizer-N in the environment to decrease their losses and increase N-use efficiency.This work provides a critical evaluation of the current and emerging methods to stabilize urea fertilizers to deliver nitrogen to the environment more sustainably. The emphasis in this review is placed on material chemistry development, such as recent emergence of urea cocrystals that possess reduced solubility and enhanced environmental stability. The materials analysis suggests that future research needs to focus on urea stabilization methods that create partial bonds between the constituents beyond weak molecular interaction. This requires avoiding unsustainable feedstock, such as formaldehyde, or exogenous stabilizing molecules that affect the soil biota, such as urease inhibitors. These developmental products then need to be transformed into thriving technologies to provide high-value fertilizers by decreasing the energy footprint needed to make ammonia, a precursor of urea.
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spelling doaj-art-55ac44d14aa14736ba2991da926e5ea12025-08-20T02:47:45ZengElsevierSustainable Chemistry for the Environment2949-83922025-03-01910020910.1016/j.scenv.2025.100209From urea to urea cocrystals: A critical view of conventional and emerging nitrogenous fertilizer materials for improved environmental sustainabilityMohamed Eisa0Mariana Brondi1Clinton Williams2Reagan Hejl3Jonas Baltrusaitis4Department of Chemical and Biomolecular Engineering, Lehigh University, B336 Iacocca Hall, 111 Research Drive, Bethlehem, PA 18015, USADepartment of Chemical and Biomolecular Engineering, Lehigh University, B336 Iacocca Hall, 111 Research Drive, Bethlehem, PA 18015, USAUSDA-ARS, US Arid Land Agricultural Research Center, 21881 N. Cardon Ln, Maricopa, AZ 85138, USAUSDA-ARS, US Arid Land Agricultural Research Center, 21881 N. Cardon Ln, Maricopa, AZ 85138, USADepartment of Chemical and Biomolecular Engineering, Lehigh University, B336 Iacocca Hall, 111 Research Drive, Bethlehem, PA 18015, USA; Corresponding author.Nitrogen (N) is a critical nutrient that is essential for plant growth and sustainable population development. Since the inception of modern fertilizer technology, N has been supplied to the environment via low-stability fertilizer materials which has resulted in very large losses of reactive nitrogen to the environment. These losses have severe impacts on soil, air and surface water locally and result in changes to the ecosystem biodiversity as well as climate globally. Synthesis of nitrogen fertilizer, such as urea, consumes 1–2 % of global energy as well as significant amounts of natural gas. Therefore, it is necessary to improve the stability of fertilizer-N in the environment to decrease their losses and increase N-use efficiency.This work provides a critical evaluation of the current and emerging methods to stabilize urea fertilizers to deliver nitrogen to the environment more sustainably. The emphasis in this review is placed on material chemistry development, such as recent emergence of urea cocrystals that possess reduced solubility and enhanced environmental stability. The materials analysis suggests that future research needs to focus on urea stabilization methods that create partial bonds between the constituents beyond weak molecular interaction. This requires avoiding unsustainable feedstock, such as formaldehyde, or exogenous stabilizing molecules that affect the soil biota, such as urease inhibitors. These developmental products then need to be transformed into thriving technologies to provide high-value fertilizers by decreasing the energy footprint needed to make ammonia, a precursor of urea.http://www.sciencedirect.com/science/article/pii/S2949839225000045UreaNitrogenInhibitorsCoatingsCocrystals
spellingShingle Mohamed Eisa
Mariana Brondi
Clinton Williams
Reagan Hejl
Jonas Baltrusaitis
From urea to urea cocrystals: A critical view of conventional and emerging nitrogenous fertilizer materials for improved environmental sustainability
Sustainable Chemistry for the Environment
Urea
Nitrogen
Inhibitors
Coatings
Cocrystals
title From urea to urea cocrystals: A critical view of conventional and emerging nitrogenous fertilizer materials for improved environmental sustainability
title_full From urea to urea cocrystals: A critical view of conventional and emerging nitrogenous fertilizer materials for improved environmental sustainability
title_fullStr From urea to urea cocrystals: A critical view of conventional and emerging nitrogenous fertilizer materials for improved environmental sustainability
title_full_unstemmed From urea to urea cocrystals: A critical view of conventional and emerging nitrogenous fertilizer materials for improved environmental sustainability
title_short From urea to urea cocrystals: A critical view of conventional and emerging nitrogenous fertilizer materials for improved environmental sustainability
title_sort from urea to urea cocrystals a critical view of conventional and emerging nitrogenous fertilizer materials for improved environmental sustainability
topic Urea
Nitrogen
Inhibitors
Coatings
Cocrystals
url http://www.sciencedirect.com/science/article/pii/S2949839225000045
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