From sensation to regulation: the diverse functions of peripheral sensory nervous system
The peripheral sensory nervous system (PNS) has been widely recognized for its role in the collection, processing, and transmission of sensory information, including thermal, mechanical, chemical, and proprioceptive stimuli. In recent years, there has been a growing scholarly interest in the PNS att...
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Frontiers Media S.A.
2025-05-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1575917/full |
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| author | Yixiao Mei Yixiao Mei Yixiao Mei Bing-Lin Zhou Da Zhong Xuan-Jie Zheng Yu-Tao Deng Lina Yu Lina Yu Bao-Chun Jiang Bao-Chun Jiang Bao-Chun Jiang |
| author_facet | Yixiao Mei Yixiao Mei Yixiao Mei Bing-Lin Zhou Da Zhong Xuan-Jie Zheng Yu-Tao Deng Lina Yu Lina Yu Bao-Chun Jiang Bao-Chun Jiang Bao-Chun Jiang |
| author_sort | Yixiao Mei |
| collection | DOAJ |
| description | The peripheral sensory nervous system (PNS) has been widely recognized for its role in the collection, processing, and transmission of sensory information, including thermal, mechanical, chemical, and proprioceptive stimuli. In recent years, there has been a growing scholarly interest in the PNS attributable to its multiple physiological and pathophysiological non-sensory roles in the organs it innervates. The PNS exerts regulatory functions within the organs it innervates through direct interactions with local cells or through microbe-nerve-cell interactions that differ from the traditional feedback regulatory modes used by the hormonal and sensory brain-sympathetic/parasympathetic systems. The release of the neuropeptide calcitonin gene related peptide (CGRP) by nerves, through its action on CGRP receptors in peripheral cells, constitutes a primary molecular axis for PNS regulation of organ cells, maintaining tissue homeostasis, facilitating pathological processes, and modulating innate and adaptive immunity. This review highlights the non-sensory functions of the peripheral sensory nervous system in various tissues and organs, focusing on phenotypes, molecular mechanisms and their significance, while also exploring future research directions, methodologies and potential preclinical studies aimed at targeting these pathways for the development of novel therapies. |
| format | Article |
| id | doaj-art-559cbd1937ed4ded8aad74705545f448 |
| institution | DOAJ |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-559cbd1937ed4ded8aad74705545f4482025-08-20T03:10:27ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-05-011610.3389/fimmu.2025.15759171575917From sensation to regulation: the diverse functions of peripheral sensory nervous systemYixiao Mei0Yixiao Mei1Yixiao Mei2Bing-Lin Zhou3Da Zhong4Xuan-Jie Zheng5Yu-Tao Deng6Lina Yu7Lina Yu8Bao-Chun Jiang9Bao-Chun Jiang10Bao-Chun Jiang11Department of Anesthesiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaZhejiang Key Laboratory of Pain Perception and Neuromodulation, Hangzhou, ChinaState Key Laboratory of Transvascular Implantation Devices, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Anesthesiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Anesthesiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Anesthesiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Anesthesiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Anesthesiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaZhejiang Key Laboratory of Pain Perception and Neuromodulation, Hangzhou, ChinaDepartment of Anesthesiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaZhejiang Key Laboratory of Pain Perception and Neuromodulation, Hangzhou, ChinaState Key Laboratory of Transvascular Implantation Devices, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaThe peripheral sensory nervous system (PNS) has been widely recognized for its role in the collection, processing, and transmission of sensory information, including thermal, mechanical, chemical, and proprioceptive stimuli. In recent years, there has been a growing scholarly interest in the PNS attributable to its multiple physiological and pathophysiological non-sensory roles in the organs it innervates. The PNS exerts regulatory functions within the organs it innervates through direct interactions with local cells or through microbe-nerve-cell interactions that differ from the traditional feedback regulatory modes used by the hormonal and sensory brain-sympathetic/parasympathetic systems. The release of the neuropeptide calcitonin gene related peptide (CGRP) by nerves, through its action on CGRP receptors in peripheral cells, constitutes a primary molecular axis for PNS regulation of organ cells, maintaining tissue homeostasis, facilitating pathological processes, and modulating innate and adaptive immunity. This review highlights the non-sensory functions of the peripheral sensory nervous system in various tissues and organs, focusing on phenotypes, molecular mechanisms and their significance, while also exploring future research directions, methodologies and potential preclinical studies aimed at targeting these pathways for the development of novel therapies.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1575917/fullperipheral sensory nervous system (PNS)sensory signal transductionnonsensory regulatory functionsneuro-immune interactionCGRP signaling pathwaymicrobe-nerve-cell crosstalk |
| spellingShingle | Yixiao Mei Yixiao Mei Yixiao Mei Bing-Lin Zhou Da Zhong Xuan-Jie Zheng Yu-Tao Deng Lina Yu Lina Yu Bao-Chun Jiang Bao-Chun Jiang Bao-Chun Jiang From sensation to regulation: the diverse functions of peripheral sensory nervous system Frontiers in Immunology peripheral sensory nervous system (PNS) sensory signal transduction nonsensory regulatory functions neuro-immune interaction CGRP signaling pathway microbe-nerve-cell crosstalk |
| title | From sensation to regulation: the diverse functions of peripheral sensory nervous system |
| title_full | From sensation to regulation: the diverse functions of peripheral sensory nervous system |
| title_fullStr | From sensation to regulation: the diverse functions of peripheral sensory nervous system |
| title_full_unstemmed | From sensation to regulation: the diverse functions of peripheral sensory nervous system |
| title_short | From sensation to regulation: the diverse functions of peripheral sensory nervous system |
| title_sort | from sensation to regulation the diverse functions of peripheral sensory nervous system |
| topic | peripheral sensory nervous system (PNS) sensory signal transduction nonsensory regulatory functions neuro-immune interaction CGRP signaling pathway microbe-nerve-cell crosstalk |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1575917/full |
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