Auricularia Auricula Polysaccharide-Mediated Green Synthesis of Highly Stable Au NPs
Polysaccharide-functionalized gold nanoparticles (Au NPs) exhibit a promising application in biomedical fields due to their excellent stability and functional properties. The Au NPs from <i>Auricularia auricula</i> polysaccharide (AAP) were successfully synthesized using a straightforwar...
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MDPI AG
2024-11-01
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| Series: | Polysaccharides |
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| Online Access: | https://www.mdpi.com/2673-4176/5/4/41 |
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| author | Haoqiang Liu Liyu Gu Yuanzhen Ye Minwei Zhang |
| author_facet | Haoqiang Liu Liyu Gu Yuanzhen Ye Minwei Zhang |
| author_sort | Haoqiang Liu |
| collection | DOAJ |
| description | Polysaccharide-functionalized gold nanoparticles (Au NPs) exhibit a promising application in biomedical fields due to their excellent stability and functional properties. The Au NPs from <i>Auricularia auricula</i> polysaccharide (AAP) were successfully synthesized using a straightforward method. By controlling the mass fraction of AAP, pH, reaction temperature, reaction time, and concentration of gold precursor, the highly dispersed spherical AAP-functionalized Au NPs (AAP-Au NPs) were prepared. The Fourier transform infrared spectrometer (FT-IR) and X-ray photoelectron spectroscopy (XPS) indicated that the synthesis mechanism of AAP-Au NPs was as follows: the molecular chain of AAP undergoes a glycosidic bond breakage to expose the reduction terminus in the presence of gold precursor, which reduced Au(III) to Au(0), and itself was oxidized to carboxylate compounds for maintaining the stability of AAP-Au NPs. Additionally, based on the electrostatic interactions and steric forces, as-prepared AAP-Au NPs exhibit excellent stability at various pH (5–11), temperature (25–60 °C), 5 mmol/L glutathione, and 0.1 mol/L Na<sup>+</sup> and K<sup>+</sup> solutions. Furthermore, AAP-Au NPs retained the ability to scavenge DDPH and ABTS radicals, which is expected to expand the application of Au NPs in biomedical fields. |
| format | Article |
| id | doaj-art-559c38c226b040eb8dcc9082d90b1389 |
| institution | DOAJ |
| issn | 2673-4176 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polysaccharides |
| spelling | doaj-art-559c38c226b040eb8dcc9082d90b13892025-08-20T02:43:20ZengMDPI AGPolysaccharides2673-41762024-11-015464365510.3390/polysaccharides5040041Auricularia Auricula Polysaccharide-Mediated Green Synthesis of Highly Stable Au NPsHaoqiang Liu0Liyu Gu1Yuanzhen Ye2Minwei Zhang3Xinjiang Key Laboratory of Biological Resources and Genetic Engineering, College of Life Science & Technology, Xinjiang University, Urumqi 830046, ChinaXinjiang Key Laboratory of Biological Resources and Genetic Engineering, College of Life Science & Technology, Xinjiang University, Urumqi 830046, ChinaXinjiang Key Laboratory of Biological Resources and Genetic Engineering, College of Life Science & Technology, Xinjiang University, Urumqi 830046, ChinaXinjiang Key Laboratory of Biological Resources and Genetic Engineering, College of Life Science & Technology, Xinjiang University, Urumqi 830046, ChinaPolysaccharide-functionalized gold nanoparticles (Au NPs) exhibit a promising application in biomedical fields due to their excellent stability and functional properties. The Au NPs from <i>Auricularia auricula</i> polysaccharide (AAP) were successfully synthesized using a straightforward method. By controlling the mass fraction of AAP, pH, reaction temperature, reaction time, and concentration of gold precursor, the highly dispersed spherical AAP-functionalized Au NPs (AAP-Au NPs) were prepared. The Fourier transform infrared spectrometer (FT-IR) and X-ray photoelectron spectroscopy (XPS) indicated that the synthesis mechanism of AAP-Au NPs was as follows: the molecular chain of AAP undergoes a glycosidic bond breakage to expose the reduction terminus in the presence of gold precursor, which reduced Au(III) to Au(0), and itself was oxidized to carboxylate compounds for maintaining the stability of AAP-Au NPs. Additionally, based on the electrostatic interactions and steric forces, as-prepared AAP-Au NPs exhibit excellent stability at various pH (5–11), temperature (25–60 °C), 5 mmol/L glutathione, and 0.1 mol/L Na<sup>+</sup> and K<sup>+</sup> solutions. Furthermore, AAP-Au NPs retained the ability to scavenge DDPH and ABTS radicals, which is expected to expand the application of Au NPs in biomedical fields.https://www.mdpi.com/2673-4176/5/4/41<i>Auricularia auricula</i> polysaccharidegold nanoparticlessynthetic mechanismantioxidant property |
| spellingShingle | Haoqiang Liu Liyu Gu Yuanzhen Ye Minwei Zhang Auricularia Auricula Polysaccharide-Mediated Green Synthesis of Highly Stable Au NPs Polysaccharides <i>Auricularia auricula</i> polysaccharide gold nanoparticles synthetic mechanism antioxidant property |
| title | Auricularia Auricula Polysaccharide-Mediated Green Synthesis of Highly Stable Au NPs |
| title_full | Auricularia Auricula Polysaccharide-Mediated Green Synthesis of Highly Stable Au NPs |
| title_fullStr | Auricularia Auricula Polysaccharide-Mediated Green Synthesis of Highly Stable Au NPs |
| title_full_unstemmed | Auricularia Auricula Polysaccharide-Mediated Green Synthesis of Highly Stable Au NPs |
| title_short | Auricularia Auricula Polysaccharide-Mediated Green Synthesis of Highly Stable Au NPs |
| title_sort | auricularia auricula polysaccharide mediated green synthesis of highly stable au nps |
| topic | <i>Auricularia auricula</i> polysaccharide gold nanoparticles synthetic mechanism antioxidant property |
| url | https://www.mdpi.com/2673-4176/5/4/41 |
| work_keys_str_mv | AT haoqiangliu auriculariaauriculapolysaccharidemediatedgreensynthesisofhighlystableaunps AT liyugu auriculariaauriculapolysaccharidemediatedgreensynthesisofhighlystableaunps AT yuanzhenye auriculariaauriculapolysaccharidemediatedgreensynthesisofhighlystableaunps AT minweizhang auriculariaauriculapolysaccharidemediatedgreensynthesisofhighlystableaunps |