Predictors of subclinical interstitial lung disease in patients with obstructive sleep apnea
Rationale The association between interstitial lung disease (ILD) and obstructive sleep apnea (OSA) is commonly encountered in clinical practice. ILD diagnosis can be easily missed in those patients. Objective To investigate for predictors of ILD in patients with OSA. Methods This is a prospective o...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2025-04-01
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| Series: | Egyptian Journal of Chest Disease and Tuberculosis |
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| Online Access: | https://doi.org/10.4103/ecdt.ecdt_51_24 |
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| author | Mohamed F.A. Yassen Hend M. Sayed Samaa M. Elkossi Mohammad G.A. Khalaf |
| author_facet | Mohamed F.A. Yassen Hend M. Sayed Samaa M. Elkossi Mohammad G.A. Khalaf |
| author_sort | Mohamed F.A. Yassen |
| collection | DOAJ |
| description | Rationale The association between interstitial lung disease (ILD) and obstructive sleep apnea (OSA) is commonly encountered in clinical practice. ILD diagnosis can be easily missed in those patients. Objective To investigate for predictors of ILD in patients with OSA. Methods This is a prospective observational study. 309 patients presented to polysomnography unit in Assiut University Hospital, diagnosed with OSA [Respiratory Disturbance Index (RDI) more than 5] were reviewed. High resolution computed tomography (HRCT) chest was done for all included patients to screen for ILD. Spirometry was done to evaluate the severity of the restriction. Echocardiography was performed by a cardiologist to screen for pulmonary hypertension. Results In all 228 (73.8%) patients had normal HRCT. Eighty-one (26.2%) cases were found to have features of ILD in HRCT chest. Patients with subclinical ILD 73 (90.1%) cases had significantly higher RDI when compared with known cases of ILD 8 (9.9%) cases. Their level of PO2 and forced vital capacity (FVC) were significantly reduced (P=0.003, and <0.001, respectively). There was significant negative correlation between RDI and Desaturation Index (DI) (r= –0.476, P<0.001), PO2 (r=–0.598, P<0.001), and FVC (r=– 0.576, P<0.001). Younger age at admission, higher RDI, lower FVC, and prolonged forced expiratory volume in one second/FVC are significant predictors for subclinical ILD among patients with OSA. Conclusions ILD is a notable association in patients with OSA. The younger age at diagnosis, higher RDI, lower FVC, and higher ratio of forced expiratory volume in one second/FVC are significant predictors for subclinical or undiagnosed ILD among patients with OSA. Clinical trial.gov: NCT06058052 |
| format | Article |
| id | doaj-art-5599c0eeb6ca4b2eaa96a147d86922d9 |
| institution | Kabale University |
| issn | 0422-7638 2090-9950 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Egyptian Journal of Chest Disease and Tuberculosis |
| spelling | doaj-art-5599c0eeb6ca4b2eaa96a147d86922d92025-08-20T03:49:46ZengWolters Kluwer Medknow PublicationsEgyptian Journal of Chest Disease and Tuberculosis0422-76382090-99502025-04-0174216617210.4103/ecdt.ecdt_51_24Predictors of subclinical interstitial lung disease in patients with obstructive sleep apneaMohamed F.A. YassenHend M. SayedSamaa M. ElkossiMohammad G.A. KhalafRationale The association between interstitial lung disease (ILD) and obstructive sleep apnea (OSA) is commonly encountered in clinical practice. ILD diagnosis can be easily missed in those patients. Objective To investigate for predictors of ILD in patients with OSA. Methods This is a prospective observational study. 309 patients presented to polysomnography unit in Assiut University Hospital, diagnosed with OSA [Respiratory Disturbance Index (RDI) more than 5] were reviewed. High resolution computed tomography (HRCT) chest was done for all included patients to screen for ILD. Spirometry was done to evaluate the severity of the restriction. Echocardiography was performed by a cardiologist to screen for pulmonary hypertension. Results In all 228 (73.8%) patients had normal HRCT. Eighty-one (26.2%) cases were found to have features of ILD in HRCT chest. Patients with subclinical ILD 73 (90.1%) cases had significantly higher RDI when compared with known cases of ILD 8 (9.9%) cases. Their level of PO2 and forced vital capacity (FVC) were significantly reduced (P=0.003, and <0.001, respectively). There was significant negative correlation between RDI and Desaturation Index (DI) (r= –0.476, P<0.001), PO2 (r=–0.598, P<0.001), and FVC (r=– 0.576, P<0.001). Younger age at admission, higher RDI, lower FVC, and prolonged forced expiratory volume in one second/FVC are significant predictors for subclinical ILD among patients with OSA. Conclusions ILD is a notable association in patients with OSA. The younger age at diagnosis, higher RDI, lower FVC, and higher ratio of forced expiratory volume in one second/FVC are significant predictors for subclinical or undiagnosed ILD among patients with OSA. Clinical trial.gov: NCT06058052https://doi.org/10.4103/ecdt.ecdt_51_24high resolution computed tomographyintestinal lung diseaseobstructive sleep apnea |
| spellingShingle | Mohamed F.A. Yassen Hend M. Sayed Samaa M. Elkossi Mohammad G.A. Khalaf Predictors of subclinical interstitial lung disease in patients with obstructive sleep apnea Egyptian Journal of Chest Disease and Tuberculosis high resolution computed tomography intestinal lung disease obstructive sleep apnea |
| title | Predictors of subclinical interstitial lung disease in patients with obstructive sleep apnea |
| title_full | Predictors of subclinical interstitial lung disease in patients with obstructive sleep apnea |
| title_fullStr | Predictors of subclinical interstitial lung disease in patients with obstructive sleep apnea |
| title_full_unstemmed | Predictors of subclinical interstitial lung disease in patients with obstructive sleep apnea |
| title_short | Predictors of subclinical interstitial lung disease in patients with obstructive sleep apnea |
| title_sort | predictors of subclinical interstitial lung disease in patients with obstructive sleep apnea |
| topic | high resolution computed tomography intestinal lung disease obstructive sleep apnea |
| url | https://doi.org/10.4103/ecdt.ecdt_51_24 |
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