Identification of diagnostic and therapeutic biomarkers for attention‐deficit/hyperactivity disorder
Abstract Attention‐deficit/hyperactivity disorder (ADHD) is a common psychiatric condition among children and adolescents, often associated with a high risk of psychiatric comorbidities. Currently, ADHD diagnosis relies exclusively on clinical presentation and patient history, underscoring the need...
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| Format: | Article |
| Language: | English |
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Wiley
2025-04-01
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| Series: | Kaohsiung Journal of Medical Sciences |
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| Online Access: | https://doi.org/10.1002/kjm2.12931 |
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| author | Sheng‐Yu Lee Liang‐Jen Wang Cheng‐Fang Yen |
| author_facet | Sheng‐Yu Lee Liang‐Jen Wang Cheng‐Fang Yen |
| author_sort | Sheng‐Yu Lee |
| collection | DOAJ |
| description | Abstract Attention‐deficit/hyperactivity disorder (ADHD) is a common psychiatric condition among children and adolescents, often associated with a high risk of psychiatric comorbidities. Currently, ADHD diagnosis relies exclusively on clinical presentation and patient history, underscoring the need for clinically relevant, reliable, and objective biomarkers. Such biomarkers may enable earlier diagnosis and lead to improved treatment outcomes. Our research team has focused on identifying potential biomarkers for ADHD by investigating its possible pathomechanisms, with consideration of the aforementioned criteria. Given the significant sex‐related differences in ADHD prevalence (male predominance) and the age‐related variability in its symptomatology, we explored the role of neuroendocrine systems in ADHD. Specifically, we examined the epigenetic regulation mechanism involved in ADHD pathogenesis and developed a diagnostic model based on peripheral microRNA. Additionally, we investigated the role of microbiota dysbiosis in the pathophysiology of ADHD and provided novel insights into its management. This paper presents a summary of our findings on potential biomarkers for ADHD. By analyzing blood, salivary, and fecal samples, we identified several promising biomarkers that may serve as objective parameters for improving the diagnostic accuracy for ADHD. Further research involving larger cohort studies is required to confirm the reliability of these biomarkers. |
| format | Article |
| id | doaj-art-559754f556fb4bdbb2997c2fdb635eb8 |
| institution | OA Journals |
| issn | 1607-551X 2410-8650 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Kaohsiung Journal of Medical Sciences |
| spelling | doaj-art-559754f556fb4bdbb2997c2fdb635eb82025-08-20T01:54:54ZengWileyKaohsiung Journal of Medical Sciences1607-551X2410-86502025-04-01414n/an/a10.1002/kjm2.12931Identification of diagnostic and therapeutic biomarkers for attention‐deficit/hyperactivity disorderSheng‐Yu Lee0Liang‐Jen Wang1Cheng‐Fang Yen2Department of Psychiatry Kaohsiung Veterans General Hospital Kaohsiung TaiwanDepartment of Child and Adolescent Psychiatry Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung TaiwanDepartment of Psychiatry, School of Medicine Kaohsiung Medical University Kaohsiung TaiwanAbstract Attention‐deficit/hyperactivity disorder (ADHD) is a common psychiatric condition among children and adolescents, often associated with a high risk of psychiatric comorbidities. Currently, ADHD diagnosis relies exclusively on clinical presentation and patient history, underscoring the need for clinically relevant, reliable, and objective biomarkers. Such biomarkers may enable earlier diagnosis and lead to improved treatment outcomes. Our research team has focused on identifying potential biomarkers for ADHD by investigating its possible pathomechanisms, with consideration of the aforementioned criteria. Given the significant sex‐related differences in ADHD prevalence (male predominance) and the age‐related variability in its symptomatology, we explored the role of neuroendocrine systems in ADHD. Specifically, we examined the epigenetic regulation mechanism involved in ADHD pathogenesis and developed a diagnostic model based on peripheral microRNA. Additionally, we investigated the role of microbiota dysbiosis in the pathophysiology of ADHD and provided novel insights into its management. This paper presents a summary of our findings on potential biomarkers for ADHD. By analyzing blood, salivary, and fecal samples, we identified several promising biomarkers that may serve as objective parameters for improving the diagnostic accuracy for ADHD. Further research involving larger cohort studies is required to confirm the reliability of these biomarkers.https://doi.org/10.1002/kjm2.12931attention‐deficit/hyperactivity disorder (ADHD)biomarkermicrobiotamiRNAneuroendocrine |
| spellingShingle | Sheng‐Yu Lee Liang‐Jen Wang Cheng‐Fang Yen Identification of diagnostic and therapeutic biomarkers for attention‐deficit/hyperactivity disorder Kaohsiung Journal of Medical Sciences attention‐deficit/hyperactivity disorder (ADHD) biomarker microbiota miRNA neuroendocrine |
| title | Identification of diagnostic and therapeutic biomarkers for attention‐deficit/hyperactivity disorder |
| title_full | Identification of diagnostic and therapeutic biomarkers for attention‐deficit/hyperactivity disorder |
| title_fullStr | Identification of diagnostic and therapeutic biomarkers for attention‐deficit/hyperactivity disorder |
| title_full_unstemmed | Identification of diagnostic and therapeutic biomarkers for attention‐deficit/hyperactivity disorder |
| title_short | Identification of diagnostic and therapeutic biomarkers for attention‐deficit/hyperactivity disorder |
| title_sort | identification of diagnostic and therapeutic biomarkers for attention deficit hyperactivity disorder |
| topic | attention‐deficit/hyperactivity disorder (ADHD) biomarker microbiota miRNA neuroendocrine |
| url | https://doi.org/10.1002/kjm2.12931 |
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