ZAR1/2‐Regulated Epigenetic Modifications are Essential for Age‐Associated Oocyte Quality Maintenance and Zygotic Activation

ZAR1/2‐Regulated Epigenetic Modifications are Essential for Age‐Associated Oocyte Quality Maintenance and Zygotic Activation

Abstract The developmental competence and epigenetic progression of oocytes gradually become dysregulated with increasing maternal age. However, the mechanisms underlying age‐related epigenetic regulation in oocytes remain poorly understood. Zygote arrest proteins 1 and 2 (ZAR1/2) are two maternal f...

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Main Authors: Yan Rong, Yu‐Ke Wu, Yingyan Chen, Qing Liu, Leilei Ai, Yun‐Wen Wu, Yezhang Zhu, Yin‐Li Zhang, Chengkan Liu, Yerong Ma, Xiaomei Tong, Jiamin Jin, Xiaoxuan Li, Yan Zhou, Shu‐Yan Ji, Songying Zhang, Heng‐Yu Fan
Format: Article
Language:English
Published: Wiley 2025-02-01
Series:Advanced Science
Subjects:
histone modifications
maternal factor
oocyte epigenetic maturation
oocyte‐to‐embryo transition
reproductive aging
Online Access:https://doi.org/10.1002/advs.202410305
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