Leukotriene inhibition in hamster periodontitis. A histochemical and morphometric study
The effects of leukotriene (LT) inhibition on gingival and adjacent bone compartments were assessed by using phenidone (100 mg/kg/d) and ketoconazole (50 mg/kg/d) given for 4 weeks to periodontitis-affected hamsters. In the gingiva the two agents significantly decreased PMNL recruitment and migratio...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
1992-01-01
|
| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/S0962935192000504 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832564606756716544 |
|---|---|
| author | B. Baroukh J. L. Saffar |
| author_facet | B. Baroukh J. L. Saffar |
| author_sort | B. Baroukh |
| collection | DOAJ |
| description | The effects of leukotriene (LT) inhibition on gingival and adjacent bone compartments were assessed by using phenidone (100 mg/kg/d) and ketoconazole (50 mg/kg/d) given for 4 weeks to periodontitis-affected hamsters. In the gingiva the two agents significantly decreased PMNL recruitment and migration and increased the vascular lumen. At the bone level, they reduced significantly preosteoclast and osteoclast numbers but did not affect osteoclast activity. Phenidone had no action on periodontitis induced inhibition of bone formation; in contrast ketoconazole enhanced formation. As both phenidone and ketoconazole are unspecific LT inhibitors it cannot be ascertained that the effects observed were actually due to LT inhibition. However, phenidone and ketoconazole induced changes different from indomethacin used in previous studies to inhibit the cyclooxygenase pathway. These discrepancies suggest that LT inhibition occurred in the present study and that they participate in gingival inflammation and osteoclastic destruction during hamster periodontitis. |
| format | Article |
| id | doaj-art-559309170eee46d1bb95836a6c19e3f1 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 1992-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-559309170eee46d1bb95836a6c19e3f12025-02-03T01:10:33ZengWileyMediators of Inflammation0962-93511466-18611992-01-011533533910.1155/S0962935192000504Leukotriene inhibition in hamster periodontitis. A histochemical and morphometric studyB. Baroukh0J. L. Saffar1Laboratoire de Biologie et Biomatériaux du Milieu Buccal et Osseux, Groupe Physiopathologie Osseuse, Faculté de Chirurgie Dentaire, Université Paris-V, 1 rue Maurice Arnoux, Montrouge 92120, FranceLaboratoire de Biologie et Biomatériaux du Milieu Buccal et Osseux, Groupe Physiopathologie Osseuse, Faculté de Chirurgie Dentaire, Université Paris-V, 1 rue Maurice Arnoux, Montrouge 92120, FranceThe effects of leukotriene (LT) inhibition on gingival and adjacent bone compartments were assessed by using phenidone (100 mg/kg/d) and ketoconazole (50 mg/kg/d) given for 4 weeks to periodontitis-affected hamsters. In the gingiva the two agents significantly decreased PMNL recruitment and migration and increased the vascular lumen. At the bone level, they reduced significantly preosteoclast and osteoclast numbers but did not affect osteoclast activity. Phenidone had no action on periodontitis induced inhibition of bone formation; in contrast ketoconazole enhanced formation. As both phenidone and ketoconazole are unspecific LT inhibitors it cannot be ascertained that the effects observed were actually due to LT inhibition. However, phenidone and ketoconazole induced changes different from indomethacin used in previous studies to inhibit the cyclooxygenase pathway. These discrepancies suggest that LT inhibition occurred in the present study and that they participate in gingival inflammation and osteoclastic destruction during hamster periodontitis.http://dx.doi.org/10.1155/S0962935192000504 |
| spellingShingle | B. Baroukh J. L. Saffar Leukotriene inhibition in hamster periodontitis. A histochemical and morphometric study Mediators of Inflammation |
| title | Leukotriene inhibition in hamster periodontitis. A histochemical and morphometric study |
| title_full | Leukotriene inhibition in hamster periodontitis. A histochemical and morphometric study |
| title_fullStr | Leukotriene inhibition in hamster periodontitis. A histochemical and morphometric study |
| title_full_unstemmed | Leukotriene inhibition in hamster periodontitis. A histochemical and morphometric study |
| title_short | Leukotriene inhibition in hamster periodontitis. A histochemical and morphometric study |
| title_sort | leukotriene inhibition in hamster periodontitis a histochemical and morphometric study |
| url | http://dx.doi.org/10.1155/S0962935192000504 |
| work_keys_str_mv | AT bbaroukh leukotrieneinhibitioninhamsterperiodontitisahistochemicalandmorphometricstudy AT jlsaffar leukotrieneinhibitioninhamsterperiodontitisahistochemicalandmorphometricstudy |