Microglia efferocytosis: an emerging mechanism for the resolution of neuroinflammation in Alzheimer’s disease
Abstract Alzheimer’s disease (AD) is a complex neurodegenerative disorder characterized by significant neuroinflammatory responses. Microglia, the immune cells of the central nervous system, play a crucial role in the pathophysiology of AD. Recent studies have indicated that microglial efferocytosis...
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| Format: | Article |
| Language: | English |
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BMC
2025-03-01
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| Series: | Journal of Neuroinflammation |
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| Online Access: | https://doi.org/10.1186/s12974-025-03428-0 |
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| author | Yongping Chen Yuhong Kou Yang Ni Haotian Yang Cailin Xu Honggang Fan Huanqi Liu |
| author_facet | Yongping Chen Yuhong Kou Yang Ni Haotian Yang Cailin Xu Honggang Fan Huanqi Liu |
| author_sort | Yongping Chen |
| collection | DOAJ |
| description | Abstract Alzheimer’s disease (AD) is a complex neurodegenerative disorder characterized by significant neuroinflammatory responses. Microglia, the immune cells of the central nervous system, play a crucial role in the pathophysiology of AD. Recent studies have indicated that microglial efferocytosis is an important mechanism for clearing apoptotic cells and cellular debris, facilitating the resolution of neuroinflammation. This review summarizes the biological characteristics of microglia and the mechanisms underlying microglial efferocytosis, including the factors and signaling pathways that regulate efferocytosis, the interactions between microglia and other cells that influence this process, and the role of neuroinflammation in AD. Furthermore, we explore the role of microglial efferocytosis in AD from three perspectives: its impact on the clearance of amyloid plaques, its regulation of neuroinflammation, and its effects on neuroprotection. Finally, we summarize the current research status on enhancing microglial efferocytosis to alleviate neuroinflammation and improve AD, as well as the future challenges of this approach as a therapeutic strategy for AD. |
| format | Article |
| id | doaj-art-558c6546110246e9a2192afeefd77796 |
| institution | DOAJ |
| issn | 1742-2094 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Neuroinflammation |
| spelling | doaj-art-558c6546110246e9a2192afeefd777962025-08-20T02:49:25ZengBMCJournal of Neuroinflammation1742-20942025-03-0122111110.1186/s12974-025-03428-0Microglia efferocytosis: an emerging mechanism for the resolution of neuroinflammation in Alzheimer’s diseaseYongping Chen0Yuhong Kou1Yang Ni2Haotian Yang3Cailin Xu4Honggang Fan5Huanqi Liu6College of Veterinary Medicine, Qingdao Agricultural UniversityHeilongjiang Key Laboratory for Laboratory Animals and Comparative Medicine, College of Veterinary Medicine, Northeast Agricultural UniversityCollege of Veterinary Medicine, Qingdao Agricultural UniversityHeilongjiang Key Laboratory for Laboratory Animals and Comparative Medicine, College of Veterinary Medicine, Northeast Agricultural UniversityCollege of Veterinary Medicine, Qingdao Agricultural UniversityHeilongjiang Key Laboratory for Laboratory Animals and Comparative Medicine, College of Veterinary Medicine, Northeast Agricultural UniversityCollege of Veterinary Medicine, Qingdao Agricultural UniversityAbstract Alzheimer’s disease (AD) is a complex neurodegenerative disorder characterized by significant neuroinflammatory responses. Microglia, the immune cells of the central nervous system, play a crucial role in the pathophysiology of AD. Recent studies have indicated that microglial efferocytosis is an important mechanism for clearing apoptotic cells and cellular debris, facilitating the resolution of neuroinflammation. This review summarizes the biological characteristics of microglia and the mechanisms underlying microglial efferocytosis, including the factors and signaling pathways that regulate efferocytosis, the interactions between microglia and other cells that influence this process, and the role of neuroinflammation in AD. Furthermore, we explore the role of microglial efferocytosis in AD from three perspectives: its impact on the clearance of amyloid plaques, its regulation of neuroinflammation, and its effects on neuroprotection. Finally, we summarize the current research status on enhancing microglial efferocytosis to alleviate neuroinflammation and improve AD, as well as the future challenges of this approach as a therapeutic strategy for AD.https://doi.org/10.1186/s12974-025-03428-0MicrogliaEfferocytosisNeuroinflammationAlzheimer’s diseaseNeurodegenerative disease |
| spellingShingle | Yongping Chen Yuhong Kou Yang Ni Haotian Yang Cailin Xu Honggang Fan Huanqi Liu Microglia efferocytosis: an emerging mechanism for the resolution of neuroinflammation in Alzheimer’s disease Journal of Neuroinflammation Microglia Efferocytosis Neuroinflammation Alzheimer’s disease Neurodegenerative disease |
| title | Microglia efferocytosis: an emerging mechanism for the resolution of neuroinflammation in Alzheimer’s disease |
| title_full | Microglia efferocytosis: an emerging mechanism for the resolution of neuroinflammation in Alzheimer’s disease |
| title_fullStr | Microglia efferocytosis: an emerging mechanism for the resolution of neuroinflammation in Alzheimer’s disease |
| title_full_unstemmed | Microglia efferocytosis: an emerging mechanism for the resolution of neuroinflammation in Alzheimer’s disease |
| title_short | Microglia efferocytosis: an emerging mechanism for the resolution of neuroinflammation in Alzheimer’s disease |
| title_sort | microglia efferocytosis an emerging mechanism for the resolution of neuroinflammation in alzheimer s disease |
| topic | Microglia Efferocytosis Neuroinflammation Alzheimer’s disease Neurodegenerative disease |
| url | https://doi.org/10.1186/s12974-025-03428-0 |
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