Influence of myosteatosis on survival of patients with pancreatic cancer: A systematic review and meta-analysis
Summary: The present meta-analysis aims to evaluate the impact of myosteatosis on overall survival (OS) and progression-free survival (PFS) in patients with pancreatic cancer (PC). A comprehensive literature search was conducted in the Medline, Web of Science, and Embase databases. The hazard ratio...
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| Language: | English |
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Elsevier
2024-12-01
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| Series: | iScience |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004224025689 |
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| author | Xin Zhang Licheng Wei Jiangguo Li Yuexia Deng Wei Xu Dongkui Chen Xing Li |
| author_facet | Xin Zhang Licheng Wei Jiangguo Li Yuexia Deng Wei Xu Dongkui Chen Xing Li |
| author_sort | Xin Zhang |
| collection | DOAJ |
| description | Summary: The present meta-analysis aims to evaluate the impact of myosteatosis on overall survival (OS) and progression-free survival (PFS) in patients with pancreatic cancer (PC). A comprehensive literature search was conducted in the Medline, Web of Science, and Embase databases. The hazard ratio (HR) and corresponding 95% confidence interval (CI) for the association between myosteatosis and survival outcomes were pooled using a random-effects model. A total of 14 studies were included. The pooled analysis demonstrated that myosteatosis was significantly associated to poorer OS (HR: 1.50, 95% CI: 1.35–1.67, p < 0.001; I2 = 0%). The subgroup analysis revealed consistent results across various study characteristics, including geographic regions, cancer stages, follow-up durations, and study quality. In addition, myosteatosis was associated to worse PFS (HR: 1.34, 95% CI: 1.15–1.57, p < 0.001; I2 = 34%). The present meta-analysis indicates that myosteatosis is associated to significantly worse OS and PFS in patients with PC. |
| format | Article |
| id | doaj-art-558952fd4bd6441c9d8d65d5a9d52bda |
| institution | OA Journals |
| issn | 2589-0042 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj-art-558952fd4bd6441c9d8d65d5a9d52bda2025-08-20T02:35:01ZengElsevieriScience2589-00422024-12-01271211134310.1016/j.isci.2024.111343Influence of myosteatosis on survival of patients with pancreatic cancer: A systematic review and meta-analysisXin Zhang0Licheng Wei1Jiangguo Li2Yuexia Deng3Wei Xu4Dongkui Chen5Xing Li6Department of Gastroenterology, The Fourth Hospital of Changsha, Changsha City, Hunan Province 410006, P.R. ChinaDepartment of Gastroenterology, The Fourth Hospital of Changsha, Changsha City, Hunan Province 410006, P.R. ChinaDepartment of Gastroenterology, The Fourth Hospital of Changsha, Changsha City, Hunan Province 410006, P.R. ChinaDepartment of Gastroenterology, The Fourth Hospital of Changsha, Changsha City, Hunan Province 410006, P.R. ChinaDepartment of Gastroenterology, The Fourth Hospital of Changsha, Changsha City, Hunan Province 410006, P.R. ChinaDepartment of Gastroenterology, The Fourth Hospital of Changsha, Changsha City, Hunan Province 410006, P.R. ChinaDepartment of Critical Care Medicine, Changsha Hospital of Traditional Chinese Medicine (Changsha No. 8 Hospital), Changsha City, Hunan Province 410100, P.R. China; Corresponding authorSummary: The present meta-analysis aims to evaluate the impact of myosteatosis on overall survival (OS) and progression-free survival (PFS) in patients with pancreatic cancer (PC). A comprehensive literature search was conducted in the Medline, Web of Science, and Embase databases. The hazard ratio (HR) and corresponding 95% confidence interval (CI) for the association between myosteatosis and survival outcomes were pooled using a random-effects model. A total of 14 studies were included. The pooled analysis demonstrated that myosteatosis was significantly associated to poorer OS (HR: 1.50, 95% CI: 1.35–1.67, p < 0.001; I2 = 0%). The subgroup analysis revealed consistent results across various study characteristics, including geographic regions, cancer stages, follow-up durations, and study quality. In addition, myosteatosis was associated to worse PFS (HR: 1.34, 95% CI: 1.15–1.57, p < 0.001; I2 = 34%). The present meta-analysis indicates that myosteatosis is associated to significantly worse OS and PFS in patients with PC.http://www.sciencedirect.com/science/article/pii/S2589004224025689Health sciencesMedicineMedical specialtyInternal medicineOncology |
| spellingShingle | Xin Zhang Licheng Wei Jiangguo Li Yuexia Deng Wei Xu Dongkui Chen Xing Li Influence of myosteatosis on survival of patients with pancreatic cancer: A systematic review and meta-analysis iScience Health sciences Medicine Medical specialty Internal medicine Oncology |
| title | Influence of myosteatosis on survival of patients with pancreatic cancer: A systematic review and meta-analysis |
| title_full | Influence of myosteatosis on survival of patients with pancreatic cancer: A systematic review and meta-analysis |
| title_fullStr | Influence of myosteatosis on survival of patients with pancreatic cancer: A systematic review and meta-analysis |
| title_full_unstemmed | Influence of myosteatosis on survival of patients with pancreatic cancer: A systematic review and meta-analysis |
| title_short | Influence of myosteatosis on survival of patients with pancreatic cancer: A systematic review and meta-analysis |
| title_sort | influence of myosteatosis on survival of patients with pancreatic cancer a systematic review and meta analysis |
| topic | Health sciences Medicine Medical specialty Internal medicine Oncology |
| url | http://www.sciencedirect.com/science/article/pii/S2589004224025689 |
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