Redefining the role of IL-18 in post-surgical recovery and sepsis: a key mediator of inflammation resolution

Redefining the role of IL-18 in post-surgical recovery and sepsis: a key mediator of inflammation resolution

Abstract Background Timely resolution of innate immune responses activated by surgical intervention is crucial for patient recovery. While cytokines and innate immune cells are critical in inflammation resolution, the specific role of IL-18 in these processes remains controversial and underexplored....

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Main Authors: Ioanna Papatheodorou, Gabriela Blažková, Veronika Bosáková, Zuzana Tomášiková, Erin Spearing, Robin Klieber, Pavel Ostašov, Julie Štíchová, Martina Dvončová, Alexandra Mýtniková, Jan Emmer, Kamila Bendíčková, Tomáš Tomáš, Vladimír Šrámek, Petros Kolovos, Monika Holubová, Martin Helán, Marcela Vlková, Jan Frič, Marcela Hortová-Kohoutková
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Journal of Translational Medicine
Subjects:
IL-18
Inflammation resolution
Monocyte macrophage transition
Sepsis
Recovery
Cytokine profiling
Online Access:https://doi.org/10.1186/s12967-025-06652-7
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