Rationale and design of the open-label, prospective, randomized study of the efficacy of intravenous versus oral iron deficiency therapy in improving left ventricular systolic function in patients with myocardial infarction (OPERA-MI)

Rationale and design of the open-label, prospective, randomized study of the efficacy of intravenous versus oral iron deficiency therapy in improving left ventricular systolic function in patients with myocardial infarction (OPERA-MI)

Aim. Iron has a protective effect on cardiomyocytes during hypoxia, while iron deficiency (ID) directly affects its function, disrupting mitochondrial respiration, reducing their contractility and relaxation. Some studies have shown that ID is a predictor of adverse outcomes  in patients with acute...

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Bibliographic Details
Main Authors: D R Khastieva, M I Malkova, E B Zakirova, I I Zakirova, I H Valeeva, N R Khasanov
Format: Article
Language:Russian
Published: «FIRMA «SILICEA» LLC 2022-06-01
Series:Российский кардиологический журнал
Subjects:
iron deficiency
myocardial infarction
ferric carboxymaltose
left ventricular systolic function
wall motion score index
Online Access:https://russjcardiol.elpub.ru/jour/article/view/4961
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