PRMT3 drives PD-L1-mediated immune escape through activating PDHK1-regulated glycolysis in hepatocellular carcinoma

PRMT3 drives PD-L1-mediated immune escape through activating PDHK1-regulated glycolysis in hepatocellular carcinoma

Abstract Aberrant expression of programmed death ligand-1 (PD-L1) facilitates tumor immune evasion. Protein arginine methyltransferase 3 (PRMT3), a member of type I PRMT family, mediates asymmetric dimethylarginine (ADMA) modification of various substrate proteins. This study investigates the role o...

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Main Authors: Chen-Hong Ding, Fang-Zhi Yan, Bo-Nan Xu, Hui Qian, Xia-Lu Hong, Shu-Qing Liu, Yuan-Yuan Luo, Si-Han Wu, Ling-Yan Cai, Xin Zhang, Wei-Fen Xie
Format: Article
Language:English
Published: Nature Publishing Group 2025-03-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-025-07482-7
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