Epigenetic Regulation of Chondrocytes and Subchondral Bone in Osteoarthritis
The aim of this review is to provide an updated review of the epigenetic factors involved in the onset and development of osteoarthritis (OA). OA is a prevalent degenerative joint disease characterized by chronic inflammation, ectopic bone formation within the joint, and physical and proteolytic car...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-04-01
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| Series: | Life |
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| Online Access: | https://www.mdpi.com/2075-1729/12/4/582 |
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| author | Hope C. Ball Andrew L. Alejo Trinity Kronk Amanda M. Alejo Fayez F. Safadi |
| author_facet | Hope C. Ball Andrew L. Alejo Trinity Kronk Amanda M. Alejo Fayez F. Safadi |
| author_sort | Hope C. Ball |
| collection | DOAJ |
| description | The aim of this review is to provide an updated review of the epigenetic factors involved in the onset and development of osteoarthritis (OA). OA is a prevalent degenerative joint disease characterized by chronic inflammation, ectopic bone formation within the joint, and physical and proteolytic cartilage degradation which result in chronic pain and loss of mobility. At present, no disease-modifying therapeutics exist for the prevention or treatment of the disease. Research has identified several OA risk factors including mechanical stressors, physical activity, obesity, traumatic joint injury, genetic predisposition, and age. Recently, there has been increased interest in identifying epigenetic factors involved in the pathogenesis of OA. In this review, we detail several of these epigenetic modifications with known functions in the onset and progression of the disease. We also review current therapeutics targeting aberrant epigenetic regulation as potential options for preventive or therapeutic treatment. |
| format | Article |
| id | doaj-art-5571a5fb95b0431c8b7a47276c59e75d |
| institution | Kabale University |
| issn | 2075-1729 |
| language | English |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj-art-5571a5fb95b0431c8b7a47276c59e75d2025-08-20T03:49:41ZengMDPI AGLife2075-17292022-04-0112458210.3390/life12040582Epigenetic Regulation of Chondrocytes and Subchondral Bone in OsteoarthritisHope C. Ball0Andrew L. Alejo1Trinity Kronk2Amanda M. Alejo3Fayez F. Safadi4Department of Anatomy and Neurobiology, Northeast Ohio Medical University, Rootstown, OH 44272, USADepartment of Anatomy and Neurobiology, Northeast Ohio Medical University, Rootstown, OH 44272, USADepartment of Anatomy and Neurobiology, Northeast Ohio Medical University, Rootstown, OH 44272, USADepartment of Anatomy and Neurobiology, Northeast Ohio Medical University, Rootstown, OH 44272, USADepartment of Anatomy and Neurobiology, Northeast Ohio Medical University, Rootstown, OH 44272, USAThe aim of this review is to provide an updated review of the epigenetic factors involved in the onset and development of osteoarthritis (OA). OA is a prevalent degenerative joint disease characterized by chronic inflammation, ectopic bone formation within the joint, and physical and proteolytic cartilage degradation which result in chronic pain and loss of mobility. At present, no disease-modifying therapeutics exist for the prevention or treatment of the disease. Research has identified several OA risk factors including mechanical stressors, physical activity, obesity, traumatic joint injury, genetic predisposition, and age. Recently, there has been increased interest in identifying epigenetic factors involved in the pathogenesis of OA. In this review, we detail several of these epigenetic modifications with known functions in the onset and progression of the disease. We also review current therapeutics targeting aberrant epigenetic regulation as potential options for preventive or therapeutic treatment.https://www.mdpi.com/2075-1729/12/4/582osteoarthritisepigeneticsmethylationbonecartilage |
| spellingShingle | Hope C. Ball Andrew L. Alejo Trinity Kronk Amanda M. Alejo Fayez F. Safadi Epigenetic Regulation of Chondrocytes and Subchondral Bone in Osteoarthritis Life osteoarthritis epigenetics methylation bone cartilage |
| title | Epigenetic Regulation of Chondrocytes and Subchondral Bone in Osteoarthritis |
| title_full | Epigenetic Regulation of Chondrocytes and Subchondral Bone in Osteoarthritis |
| title_fullStr | Epigenetic Regulation of Chondrocytes and Subchondral Bone in Osteoarthritis |
| title_full_unstemmed | Epigenetic Regulation of Chondrocytes and Subchondral Bone in Osteoarthritis |
| title_short | Epigenetic Regulation of Chondrocytes and Subchondral Bone in Osteoarthritis |
| title_sort | epigenetic regulation of chondrocytes and subchondral bone in osteoarthritis |
| topic | osteoarthritis epigenetics methylation bone cartilage |
| url | https://www.mdpi.com/2075-1729/12/4/582 |
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