Research progress on cholesterol metabolism and tumor therapy
Abstract Cholesterol and its metabolic derivatives have important biological functions and are crucial in tumor initiation, progression, and treatment. Cholesterol maintains the physical properties of cellular membranes and is pivotal in cell signal transduction. Cholesterol metabolism includes both...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Springer
2025-04-01
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| Series: | Discover Oncology |
| Subjects: | |
| Online Access: | https://doi.org/10.1007/s12672-025-02430-5 |
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| _version_ | 1850042364519776256 |
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| author | Zewen Chu Lei Fang Yanwei Xiang Yue Ding |
| author_facet | Zewen Chu Lei Fang Yanwei Xiang Yue Ding |
| author_sort | Zewen Chu |
| collection | DOAJ |
| description | Abstract Cholesterol and its metabolic derivatives have important biological functions and are crucial in tumor initiation, progression, and treatment. Cholesterol maintains the physical properties of cellular membranes and is pivotal in cell signal transduction. Cholesterol metabolism includes both de novo synthesis and uptake from extracellular sources such as low-density lipoprotein (LDL) and high-density lipoprotein (HDL). This review explores both aspects to provide a comprehensive understanding of their roles in cancer. Cholesterol metabolism is involved in bile acid production and steroid hormone biosynthesis and is closely linked to the reprogramming of endogenous and exogenous cellular signals within the tumor microenvironment. These signals are intricately associated with key biological processes such as tumor cell proliferation, survival, invasion, and metastasis. Evidence suggests that regulating cholesterol metabolism may offer therapeutic benefits by inhibiting tumor growth, remodeling the immune microenvironment, and enhancing antitumor immune responses. This review summarizes the role of cholesterol metabolism in tumor biology and discusses the application of statins and other cholesterol metabolism inhibitors in cancer therapy, aiming to provide novel insights for the development of antitumor drugs targeting cholesterol metabolism and for advances in cancer diagnosis and treatment. |
| format | Article |
| id | doaj-art-55713e326e0e4551ae94e9a0e93ca42b |
| institution | DOAJ |
| issn | 2730-6011 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Springer |
| record_format | Article |
| series | Discover Oncology |
| spelling | doaj-art-55713e326e0e4551ae94e9a0e93ca42b2025-08-20T02:55:35ZengSpringerDiscover Oncology2730-60112025-04-0116112310.1007/s12672-025-02430-5Research progress on cholesterol metabolism and tumor therapyZewen Chu0Lei Fang1Yanwei Xiang2Yue Ding3School of Rehabilitation Science, Shanghai University of Traditional Chinese MedicineSchool of Rehabilitation Science, Shanghai University of Traditional Chinese MedicineSchool of Rehabilitation Science, Shanghai University of Traditional Chinese MedicineSchool of Pharmacy, Shanghai University of Traditional Chinese MedicineAbstract Cholesterol and its metabolic derivatives have important biological functions and are crucial in tumor initiation, progression, and treatment. Cholesterol maintains the physical properties of cellular membranes and is pivotal in cell signal transduction. Cholesterol metabolism includes both de novo synthesis and uptake from extracellular sources such as low-density lipoprotein (LDL) and high-density lipoprotein (HDL). This review explores both aspects to provide a comprehensive understanding of their roles in cancer. Cholesterol metabolism is involved in bile acid production and steroid hormone biosynthesis and is closely linked to the reprogramming of endogenous and exogenous cellular signals within the tumor microenvironment. These signals are intricately associated with key biological processes such as tumor cell proliferation, survival, invasion, and metastasis. Evidence suggests that regulating cholesterol metabolism may offer therapeutic benefits by inhibiting tumor growth, remodeling the immune microenvironment, and enhancing antitumor immune responses. This review summarizes the role of cholesterol metabolism in tumor biology and discusses the application of statins and other cholesterol metabolism inhibitors in cancer therapy, aiming to provide novel insights for the development of antitumor drugs targeting cholesterol metabolism and for advances in cancer diagnosis and treatment.https://doi.org/10.1007/s12672-025-02430-5Cholesterol metabolismTumorigenesisTherapyClinical application |
| spellingShingle | Zewen Chu Lei Fang Yanwei Xiang Yue Ding Research progress on cholesterol metabolism and tumor therapy Discover Oncology Cholesterol metabolism Tumorigenesis Therapy Clinical application |
| title | Research progress on cholesterol metabolism and tumor therapy |
| title_full | Research progress on cholesterol metabolism and tumor therapy |
| title_fullStr | Research progress on cholesterol metabolism and tumor therapy |
| title_full_unstemmed | Research progress on cholesterol metabolism and tumor therapy |
| title_short | Research progress on cholesterol metabolism and tumor therapy |
| title_sort | research progress on cholesterol metabolism and tumor therapy |
| topic | Cholesterol metabolism Tumorigenesis Therapy Clinical application |
| url | https://doi.org/10.1007/s12672-025-02430-5 |
| work_keys_str_mv | AT zewenchu researchprogressoncholesterolmetabolismandtumortherapy AT leifang researchprogressoncholesterolmetabolismandtumortherapy AT yanweixiang researchprogressoncholesterolmetabolismandtumortherapy AT yueding researchprogressoncholesterolmetabolismandtumortherapy |