Synthesis of nanoparticles using advanced techniques

Nanoparticles, defined by at least one dimension in the nanometer range, exhibit exceptional physical, chemical, and biological properties that have led to groundbreaking advancements in medicine, electronics, and catalysis. Their synthesis is a critical step in optimizing their properties for speci...

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Main Authors: Anjaneyulu Vinukonda, Nirosha Bolledla, Rajendra Kumar Jadi, Ravikanth Chinthala, Venkat Ratnam Devadasu
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Next Nanotechnology
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Online Access:http://www.sciencedirect.com/science/article/pii/S2949829525000385
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author Anjaneyulu Vinukonda
Nirosha Bolledla
Rajendra Kumar Jadi
Ravikanth Chinthala
Venkat Ratnam Devadasu
author_facet Anjaneyulu Vinukonda
Nirosha Bolledla
Rajendra Kumar Jadi
Ravikanth Chinthala
Venkat Ratnam Devadasu
author_sort Anjaneyulu Vinukonda
collection DOAJ
description Nanoparticles, defined by at least one dimension in the nanometer range, exhibit exceptional physical, chemical, and biological properties that have led to groundbreaking advancements in medicine, electronics, and catalysis. Their synthesis is a critical step in optimizing their properties for specific applications. This review explores the major nanoparticle fabrication techniques, categorizing them into physical, chemical, and biological methods. Physical methods, such as gas-phase condensation and sputtering, enable large-scale production but often require high-energy inputs, sophisticated equipment, and may introduce impurities. Chemical methods, including precipitation, sol-gel, and hydrothermal synthesis, provide better control over nanoparticle size, shape, and composition but can involve complex reaction mechanisms and require extensive purification steps. Biological synthesis, utilizing microorganisms, plant extracts, or enzymes, offers a sustainable and eco-friendly alternative, yet scalability and reproducibility remain challenges.Compared to existing literature, this review highlights recent advancements in hybrid approaches that integrate multiple synthesis strategies to improve efficiency, purity, and scalability. Emerging techniques, such as laser ablation-assisted chemical synthesis and bio-inspired hybrid methods, have demonstrated potential in overcoming the limitations of conventional approaches. By critically analyzing the advantages, limitations, and recent progress in nanoparticle synthesis, this review provides a comprehensive understanding of current trends and future prospects in the field. As research continues, the development of novel synthesis techniques with enhanced precision, reduced environmental impact, and cost-effectiveness is expected to drive further innovation in nanotechnology, expanding its applications across diverse industries.
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spelling doaj-art-5570a58214a64b549cf96e6ae7e2cdff2025-08-20T03:18:30ZengElsevierNext Nanotechnology2949-82952025-01-01810016910.1016/j.nxnano.2025.100169Synthesis of nanoparticles using advanced techniquesAnjaneyulu Vinukonda0Nirosha Bolledla1Rajendra Kumar Jadi2Ravikanth Chinthala3Venkat Ratnam Devadasu4Strides Pharma Inc, New York, USADepartment of Pharmaceutics, School of Pharmacy, Anurag University (Formerly Anurag Group of Institutions), Venkatapur, Ghatkesar, Medchal-Malkajgiri, Hyderabad, Telangana 500088, IndiaDepartment of Pharmaceutics, School of Pharmacy, Anurag University (Formerly Anurag Group of Institutions), Venkatapur, Ghatkesar, Medchal-Malkajgiri, Hyderabad, Telangana 500088, IndiaDepartment of Pharmacology, Palamuru University, Mahabubnagar, Telangana, IndiaDepartment of Pharmaceutics, St. Pauls College of Pharmacy, Turkayamjal, Hyderabad, Telangana 501510, India; Corresponding author.Nanoparticles, defined by at least one dimension in the nanometer range, exhibit exceptional physical, chemical, and biological properties that have led to groundbreaking advancements in medicine, electronics, and catalysis. Their synthesis is a critical step in optimizing their properties for specific applications. This review explores the major nanoparticle fabrication techniques, categorizing them into physical, chemical, and biological methods. Physical methods, such as gas-phase condensation and sputtering, enable large-scale production but often require high-energy inputs, sophisticated equipment, and may introduce impurities. Chemical methods, including precipitation, sol-gel, and hydrothermal synthesis, provide better control over nanoparticle size, shape, and composition but can involve complex reaction mechanisms and require extensive purification steps. Biological synthesis, utilizing microorganisms, plant extracts, or enzymes, offers a sustainable and eco-friendly alternative, yet scalability and reproducibility remain challenges.Compared to existing literature, this review highlights recent advancements in hybrid approaches that integrate multiple synthesis strategies to improve efficiency, purity, and scalability. Emerging techniques, such as laser ablation-assisted chemical synthesis and bio-inspired hybrid methods, have demonstrated potential in overcoming the limitations of conventional approaches. By critically analyzing the advantages, limitations, and recent progress in nanoparticle synthesis, this review provides a comprehensive understanding of current trends and future prospects in the field. As research continues, the development of novel synthesis techniques with enhanced precision, reduced environmental impact, and cost-effectiveness is expected to drive further innovation in nanotechnology, expanding its applications across diverse industries.http://www.sciencedirect.com/science/article/pii/S2949829525000385NanoparticlesSynthesisSynthetic techniquesNanomedicine
spellingShingle Anjaneyulu Vinukonda
Nirosha Bolledla
Rajendra Kumar Jadi
Ravikanth Chinthala
Venkat Ratnam Devadasu
Synthesis of nanoparticles using advanced techniques
Next Nanotechnology
Nanoparticles
Synthesis
Synthetic techniques
Nanomedicine
title Synthesis of nanoparticles using advanced techniques
title_full Synthesis of nanoparticles using advanced techniques
title_fullStr Synthesis of nanoparticles using advanced techniques
title_full_unstemmed Synthesis of nanoparticles using advanced techniques
title_short Synthesis of nanoparticles using advanced techniques
title_sort synthesis of nanoparticles using advanced techniques
topic Nanoparticles
Synthesis
Synthetic techniques
Nanomedicine
url http://www.sciencedirect.com/science/article/pii/S2949829525000385
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