Implementing recommendations for routine mismatch repair (MMR) immunohistochemistry (IHC) testing of endometrial cancer and subsequent patient management
Lynch syndrome is associated with an increased risk of cancer, including endometrial cancer. We audited the introduction of a nurse-led testing and management pathway for Lynch syndrome. All 191 patients diagnosed with endometrial cancer at Somerset NHS Foundation Trust between January 2022 and Dece...
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2025-01-01
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| Series: | BMJ Open Quality |
| Online Access: | https://bmjopenquality.bmj.com/content/14/1/e003014.full |
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| _version_ | 1832542649468321792 |
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| author | Jo Morrison Mohamed Shawky Maria Murrey |
| author_facet | Jo Morrison Mohamed Shawky Maria Murrey |
| author_sort | Jo Morrison |
| collection | DOAJ |
| description | Lynch syndrome is associated with an increased risk of cancer, including endometrial cancer. We audited the introduction of a nurse-led testing and management pathway for Lynch syndrome. All 191 patients diagnosed with endometrial cancer at Somerset NHS Foundation Trust between January 2022 and December 2023 were tested for mis-match repair (MMR) protein immunohistochemistry; germline testing was offered to all 13 who were eligible. Seven patients were diagnosed with Lynch syndrome; all were referred for bowel screening and Helicobacter pylori testing. Information about prophylactic aspirin recommendations was missing for 3/7 patients. We established an effective, nurse-led Lynch syndrome testing pathway, in line with national guidelines. |
| format | Article |
| id | doaj-art-556bb20e81dc4f768e6ab084289f712a |
| institution | Kabale University |
| issn | 2399-6641 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open Quality |
| spelling | doaj-art-556bb20e81dc4f768e6ab084289f712a2025-02-03T20:10:12ZengBMJ Publishing GroupBMJ Open Quality2399-66412025-01-0114110.1136/bmjoq-2024-003014Implementing recommendations for routine mismatch repair (MMR) immunohistochemistry (IHC) testing of endometrial cancer and subsequent patient managementJo Morrison0Mohamed Shawky1Maria Murrey2Gynaecological Oncology, GRACE Centre, Somerset NHS Foundation Trust, Taunton, UKGynaecological Oncology, GRACE Centre, Somerset NHS Foundation Trust, Taunton, UKGynaecological Oncology, GRACE Centre, Somerset NHS Foundation Trust, Taunton, UKLynch syndrome is associated with an increased risk of cancer, including endometrial cancer. We audited the introduction of a nurse-led testing and management pathway for Lynch syndrome. All 191 patients diagnosed with endometrial cancer at Somerset NHS Foundation Trust between January 2022 and December 2023 were tested for mis-match repair (MMR) protein immunohistochemistry; germline testing was offered to all 13 who were eligible. Seven patients were diagnosed with Lynch syndrome; all were referred for bowel screening and Helicobacter pylori testing. Information about prophylactic aspirin recommendations was missing for 3/7 patients. We established an effective, nurse-led Lynch syndrome testing pathway, in line with national guidelines.https://bmjopenquality.bmj.com/content/14/1/e003014.full |
| spellingShingle | Jo Morrison Mohamed Shawky Maria Murrey Implementing recommendations for routine mismatch repair (MMR) immunohistochemistry (IHC) testing of endometrial cancer and subsequent patient management BMJ Open Quality |
| title | Implementing recommendations for routine mismatch repair (MMR) immunohistochemistry (IHC) testing of endometrial cancer and subsequent patient management |
| title_full | Implementing recommendations for routine mismatch repair (MMR) immunohistochemistry (IHC) testing of endometrial cancer and subsequent patient management |
| title_fullStr | Implementing recommendations for routine mismatch repair (MMR) immunohistochemistry (IHC) testing of endometrial cancer and subsequent patient management |
| title_full_unstemmed | Implementing recommendations for routine mismatch repair (MMR) immunohistochemistry (IHC) testing of endometrial cancer and subsequent patient management |
| title_short | Implementing recommendations for routine mismatch repair (MMR) immunohistochemistry (IHC) testing of endometrial cancer and subsequent patient management |
| title_sort | implementing recommendations for routine mismatch repair mmr immunohistochemistry ihc testing of endometrial cancer and subsequent patient management |
| url | https://bmjopenquality.bmj.com/content/14/1/e003014.full |
| work_keys_str_mv | AT jomorrison implementingrecommendationsforroutinemismatchrepairmmrimmunohistochemistryihctestingofendometrialcancerandsubsequentpatientmanagement AT mohamedshawky implementingrecommendationsforroutinemismatchrepairmmrimmunohistochemistryihctestingofendometrialcancerandsubsequentpatientmanagement AT mariamurrey implementingrecommendationsforroutinemismatchrepairmmrimmunohistochemistryihctestingofendometrialcancerandsubsequentpatientmanagement |